Recombinant Human FYN, GST-tagged, Active
Cat.No. : | FYN-322H |
Product Overview : | Recombinant human Full-length FYN A was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=85kDa. |
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Cat. No. : | FYN-322H |
Description : | Fyn A (Fyn isoform A) is a member of the SRC tyrosine kinase oncogene family showing high homology to YES1, FGR and SRC. Fyn has been shown to phosphorylate Dab1, an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2). The interaction of Fyn and Dab1 regulates the phosphorylation, trafficking, and processing of APP and apoEr2. Fyn expression has been shown to be significantly increased in Chronic Myelogenous Leukemia (CML). Knockdown of Fyn with shRNA slows leukemia cell growth, inhibits clonogenicity, and leads to increased sensitivity to imatinib. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | Full-length. |
Applications : | Kinase Assay, Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | FYN FYN oncogene related to SRC, FGR, YES [ Homo sapiens ] |
Synonyms : | FYN oncogene related to SRC, FGR, YES; SLK; SYN; MGC45350; FYN; proto-oncogene tyrosine-protein kinase fyn; src-like kinase; Protooncogene Syn; OTTHUMP00000017917; c-syn protooncogene; src/yes-related novel; tyrosine kinase p59fyn(T); p59-Fyn; protein-tyrosine kinase fyn ; OKT3-induced calcium influx regulator; EC 2.7.10.2; OTTHUMP00000017915; OTTHUMP00000017914; src-like kinase |
Gene ID : | 2534 |
mRNA Refseq : | NM_002037 |
Protein Refseq : | NP_002028 |
UniProt ID : | P06241 |
Chromosome Location : | 6q21 |
MIM : | 137025 |
Pathway : | Adherens junction; Axon guidance; Fc epsilon RI signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Prion diseases; T cell receptor signaling pathway |
Function : | non-membrane spanning protein tyrosine kinase activity; ATP binding; glycoprotein binding; identical protein binding; manganese ion binding; metal ion binding; nucleotide binding; transferase activity; tubulin binding |
Products Types
◆ Recombinant Protein | ||
FYN-949H | Recombinant Human FYN Protein, His (Fc)-Avi-tagged | +Inquiry |
FYN-3407M | Recombinant Mouse FYN Protein, His (Fc)-Avi-tagged | +Inquiry |
Fyn-3119M | Recombinant Mouse Fyn Protein, Myc/DDK-tagged | +Inquiry |
FYN-4585H | Active Recombinant Human FYN Protein, GST/His-tagged | +Inquiry |
FYN-2083R | Recombinant Rat FYN Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FYN-6091HCL | Recombinant Human FYN 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewthe manufacturer fosters scientific collaboration and knowledge sharing among researchers.
They can offer insights into interpreting results and assist in identifying trends or patterns that may be relevant to the specific research question.
This guarantees a continuous and uninterrupted availability of the protein for researchers, eliminating concerns about potential shortages or delays.
Q&As (5)
Ask a questionFYN protein is involved in regulating synaptic plasticity, which plays a crucial role in learning and memory.
Yes, FYN protein is also associated with cancer, particularly in regulating cell proliferation and survival.
Targeting FYN protein is being studied for its potential applications in the treatment of autoimmune diseases to modulate immune responses.
Some targeted therapies aimed at inhibiting FYN protein have been explored for specific types of cancer.
Yes, FYN protein levels can be measured in clinical settings through various laboratory techniques.
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