Recombinant Human FYN Oncogene Related To SRC, FGR, YES

• Cat.No.: FYN-217H
• Product Overview: Recombinant Human FYN was expressed in E.coli, MW=50 kDa.

Specification

• Cat. No.: FYN-217H
• Description: p59-Fyn is a member of the protein-tyrosine kinase oncogene family. p59fyn is a membrane-associated non-receptor protein tyrosine kinase that belongs to the Src-family of kinases. p59-Fyn encodes a membrane-associated tyrosine kinase which is implicated in the control of cell growth. p59-Fyn associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. The unique N-terminal domain of p59fyn interacts with the CD3 and eta chains of the TcR. p59fyn can bind other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of fyn activity. p59fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation. Distinct isoforms exist due to alternative splicing.
• Source: Escherichia Coli.
• Physical Appearance: Sterile Filtered clear solution.
• Formulation: p59-Fyn at 100µg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
• Applications: ELISA • Inhibition Assays • Western Blotting.
• Purity: Proprietary chromatographic techniques and SDS-PAGE.
• Stability: Store vial at -20℃ to -80℃. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
• Tag: Non

Gene Information

• Gene Name: FYN FYN oncogene related to SRC, FGR, YES [ Homo sapiens ]
• Synonyms: FYN; FYN oncogene related to SRC, FGR, YES; SLK; SYN; MGC45350; src-like kinase; OTTHUMP00000017917; c-syn protooncogene; src/yes-related novel; tyrosine kinase p59fyn(T); protein-tyrosine kinase fyn; OKT3-induced calcium influx regulator; Proto-oncogene tyrosine-protein kinase Fyn; EC 2.7.10.2; p59-Fyn; Protooncogene Syn; OTTHUMP00000017914; OTTHUMP00000017915
• Gene ID: 2534
• mRNA Refseq: NM_002037
• Protein Refseq: NP_002028
• MIM: 137025
• UniProt ID: P06241
• Chromosome Location: 6q21
• Pathway: Adherens junction; Axon guidance; Fc epsilon RI signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Prion diseases; T cell receptor signaling pathway; Axon guidance; HIV Infection; Hemostasis; Signaling in Immune system
• Function: ATP binding; glycoprotein binding; identical protein binding; manganese ion binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; transferase activity; tubulin binding

Reviews

07/27/2020

the manufacturer fosters scientific collaboration and knowledge sharing among researchers.

02/27/2020

They can offer insights into interpreting results and assist in identifying trends or patterns that may be relevant to the specific research question.

12/23/2019

This guarantees a continuous and uninterrupted availability of the protein for researchers, eliminating concerns about potential shortages or delays.

Q&As

How does FYN protein affect synaptic plasticity?

FYN protein is involved in regulating synaptic plasticity, which plays a crucial role in learning and memory.

Is FYN protein involved in cancer biology?

Yes, FYN protein is also associated with cancer, particularly in regulating cell proliferation and survival.

Can targeting FYN protein have applications in autoimmune diseases?

Targeting FYN protein is being studied for its potential applications in the treatment of autoimmune diseases to modulate immune responses.

Are there any targeted therapies that inhibit FYN protein for cancer treatment?

Some targeted therapies aimed at inhibiting FYN protein have been explored for specific types of cancer.

Can FYN protein levels be measured in clinical settings?

Yes, FYN protein levels can be measured in clinical settings through various laboratory techniques.