• Official Full Name

    GRB2-associated binding protein 2

  • Overview

    The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their
  • Synonyms

    GAB2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Grb2 associated binder 2; KIAA0571; pp100; Grb2-associated binder 2; growth factor receptor bound protein 2-associated protein 2;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GAB2-6074HCL Recombinant Human GAB2 293 Cell Lysate HEK293 N/A
Human GAB2-4620H Recombinant Human GAB2 Protein, GST-tagged Wheat Germ GST
Human GAB2-2453H Recombinant Human GAB2 protein, His-tagged E.coli His
Human GAB2-5131HF Recombinant Full Length Human GAB2 Protein, GST-tagged In Vitro Cell Free System GST
Mouse Gab2-1851M Recombinant Mouse Gab2 protein, His & T7-tagged E.coli His/T7
Rat GAB2-2439R Recombinant Rat GAB2 Protein Mammalian Cell His
Rat GAB2-2095R Recombinant Rat GAB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GAB2-2095R-B Recombinant Rat GAB2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GAB2 Related Articles
  • GAB2 Related Gene Family
  • GAB2 Related Research Area

GAB2 involved in several pathways and played different roles in them. We selected most pathways GAB2 participated on our site, such as Ras signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Sphingolipid signaling pathwayNSMAF;MAPK10;CERS4;PRKCB;TP53;PRKCE;RAF1;RELA;LOC100328615
Phospholipase D signaling pathwayRALGDS;GRM2;PLCB4;PIK3R3;LPAR4;INS1;PTPN11;F2R;KIT
Osteoclast differentiationIFNG;OSCAR;SOCS1;MAPK10;IFNAR2;IFNGR2;TAB2;AKT1;IFNB1
Fc epsilon RI signaling pathwayPIK3CD;MAPK9;PIK3R3;PLCG1;IL4;PLA2G4C;PLCG2;PLA2G4A;AKT2
Fc gamma R-mediated phagocytosisPIK3R2;PLA2G4F;LIMK1;INPPL1;AKT1;MAPK1;HCK;AKT2;FCGR1
Chronic myeloid leukemiaMAPK3;IKBKB;TGFB1;AKT2;BRAF;BCL2L1;CBLC;SHC2;PIK3CA

GAB2 has several biochemical functions, for example, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GAB2 itself. We selected most functions GAB2 had, and list some proteins which have the same functions with GAB2. You can find most of the proteins on our site.

Function Related Protein
phosphatidylinositol-3,4,5-trisphosphate bindingCOMMD1;KIF16B;NRGN;BTK;ZFYVE16;ARHGAP9;ASAP1;AKT1;DAPP1
phosphatidylinositol-3,4-bisphosphate bindingMAPKAP1;RS1;ANXA8;PLEK;ARAP3;COMMD1;TTPA;AKT1;PHLDA3
protein bindingRASSF7;OLIG3;ARL11;NDC80;TBC1D14;DDR2;CALB1;IRAK2;EIF4E
transmembrane receptor protein tyrosine kinase adaptor activityPIK3R1;SHC1;IRS1;DOK2;FRS2;SH2B2;BLNK;GAB2;TRAT1

GAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAB2.


Huang, YJ; Frazier, ML; et al. Reverse-Phase Protein Array Analysis to Identify Biomarker Proteins in Human Pancreatic Cancer. DIGESTIVE DISEASES AND SCIENCES 59:968-975(2014).
Quintas-Cardama, A; Qiu, YH; et al. Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment. CANCER 118:5283-5292(2012).
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