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GAB2

Official Full Name

GRB2-associated binding protein 2
Overview

The Grb-associated binder (Gab) family is a family of adaptor proteins recruited by a wide variety of receptor tyrosine kinases (RTKs) such as EGFR, HGFR, insulin receptor, cytokine receptor and B cell antigen receptors. Upon stimulation of RTKs by their
Synonyms

GAB2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; Grb2 associated binder 2; KIAA0571; pp100; Grb2-associated binder 2; growth factor receptor bound protein 2-associated protein 2;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GAB2-6074HCL	Recombinant Human GAB2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	GAB2-4620H	Recombinant Human GAB2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GAB2-2453H	Recombinant Human GAB2 protein, His-tagged	E.coli	His	111-450 aa	$319 / 25ug
Human	GAB2-5131HF	Recombinant Full Length Human GAB2 Protein, GST-tagged	In Vitro Cell Free System	GST	676 amino acids	Inquiry
Mouse	Gab2-1851M	Recombinant Mouse Gab2 protein, His & T7-tagged	E.coli	His/T7	Gln357~Asp607 (Accession # Q9Z1S8)	Inquiry
Rat	GAB2-2439R	Recombinant Rat GAB2 Protein	Mammalian Cell	His		Inquiry
Rat	GAB2-2095R	Recombinant Rat GAB2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	GAB2-2095R-B	Recombinant Rat GAB2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

GAB2 involved in several pathways and played different roles in them. We selected most pathways GAB2 participated on our site, such as Ras signaling pathway, Sphingolipid signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ras signaling pathway	GNG5;PAK7;FGF7;PLA2G12A;IKBKG;RELA;PLA2G4F;RIN1;RASAL2
Sphingolipid signaling pathway	PPP2R5D;PLCB1;PPP2R3A;FCER1G;BAX;PRKCG;S1PR2;PTEN;PPP2R5C
Phospholipase D signaling pathway	RAF1;INS;PLCB2;LPAR6;PTPN11;PIK3R3;PIK3CD;PLA2G4A;LPAR5
Osteoclast differentiation	GAB2;FCGR2A;SIRPA;SIRPB1;FOSL1;MAPK11;TNFRSF11B;LILRA3;SQSTM1
Fc epsilon RI signaling pathway	VAV2;TNF;PIK3CG;PRKCA;MAPK9;MAP2K3;AKT2;IL5;RAC1
Fc gamma R-mediated phagocytosis	PIK3R2;PLA2G4F;HCK;FCGR2A;PLD2;PIK3CG;SCIN;PIK3CD;PIK3R5
Chronic myeloid leukemia	CBLB;SOS1;BCL2L1;SHC3;BAD;CTBP1;HDAC1;TGFB2;CRKL

GAB2 has several biochemical functions, for example, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GAB2 itself. We selected most functions GAB2 had, and list some proteins which have the same functions with GAB2. You can find most of the proteins on our site.

Function	Related Protein
phosphatidylinositol-3,4,5-trisphosphate binding	FERMT2;ARAP2;MYO1G;ARAP3;ZFYVE16;ANXA8;PHLDA3;GBF1;ADAP2
phosphatidylinositol-3,4-bisphosphate binding	PHLDA3;GAB2;TTPA;DAPP1;D6WSU116E;RAG2;MYO1G;PLEKHA1;NCF1
protein binding	PPP3CC;PPFIA2;S100A6;WHSC2;NLK;SEPT1;DCTN1;MGP;SHFM1
transmembrane receptor protein tyrosine kinase adaptor activity	FRS2;SH2B2;BLNK;STAP1;IRS1;GAB2;SHC1;TRAT1;PIK3R1

GAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAB2.

GRB2; PTPN11

Gene Family

Research Area

Adaptor Proteins

Adaptor Proteins in the Akt Pathway

Huang, YJ; Frazier, ML; et al. Reverse-Phase Protein Array Analysis to Identify Biomarker Proteins in Human Pancreatic Cancer. DIGESTIVE DISEASES AND SCIENCES 59:968-975(2014).

Quintas-Cardama, A; Qiu, YH; et al. Reverse phase protein array profiling reveals distinct proteomic signatures associated with chronic myeloid leukemia progression and with chronic phase in the CD34-positive compartment. CANCER 118:5283-5292(2012).