• Official Full Name

    gamma-aminobutyric acid (GABA) B receptor, 2

  • Background

    The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.
  • Synonyms

    GABBR2; gamma-aminobutyric acid (GABA) B receptor, 2; G protein coupled receptor 51 , GPR51; gamma-aminobutyric acid type B receptor subunit 2; GABABR2; GPRC3B; HG20; gb2; GABA-BR2; GABA-B-R2; GABA-B receptor 2; GABA-B receptor, R2 subunit; G protein-coup;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • Flag
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GABBR2-4629H Recombinant Human GABBR2 Protein Wheat Germ N/A
    Human GABBR2-13088H Recombinant Human GABBR2, GST-tagged E.coli GST
    Human GABBR2-6072HCL Recombinant Human GABBR2 293 Cell Lysate HEK293 N/A
    Human GABBR2-1117HFL Recombinant Human GABBR2 protein, His&Flag-tagged HEK293 His&Flag
    Human GABBR2-4630H Recombinant Human GABBR2 Protein, GST-tagged Wheat Germ GST
    Mouse GABBR2-3425M Recombinant Mouse GABBR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse GABBR2-6142M Recombinant Mouse GABBR2 Protein Mammalian Cell His
    Mouse GABBR2-3425M-B Recombinant Mouse GABBR2 Protein Pre-coupled Magnetic Beads HEK293
    Rat GABBR2-2099R-B Recombinant Rat GABBR2 Protein Pre-coupled Magnetic Beads HEK293
    Rat GABBR2-2443R Recombinant Rat GABBR2 Protein Mammalian Cell His
    Rat GABBR2-2099R Recombinant Rat GABBR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Zebrafish GABBR2-7268Z Recombinant Zebrafish GABBR2 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • GABBR2 Related Articles

    GABBR2 involved in several pathways and played different roles in them. We selected most pathways GABBR2 participated on our site, such as cAMP signaling pathway, Neuroactive ligand-receptor interaction, GABAergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GABBR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cAMP signaling pathwayPIK3CG;PIK3R1;PTGER2;GLI3;PIK3CB;DRD1A;NPY1R;ATP2B1;VAV1
    Neuroactive ligand-receptor interactionF2R;AGTR1A;TAAR12A;FPR3;ADORA2AB;DRD4B;TAAR8C;CHRND;CHRM5A
    Estrogen signaling pathwayITPR1;SRC;ITPR3;HSP90AB1;CALM1;PRKACB;PLCB4;PLCB3;CALML5

    GABBR2 has several biochemical functions, for example, contributes_to G-protein coupled GABA receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GABBR2 itself. We selected most functions GABBR2 had, and list some proteins which have the same functions with GABBR2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to G-protein coupled GABA receptor activityGABBR1;GABBR2
    protein bindingPGR;KLF6;EXOC3;Casp3;METTL21C;SDC2;POLRMT;LONP1;IFI35

    GABBR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GABBR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GABBR2.

    NSF; GABBR1; Dlg4; CERS2; SH3GL3; Cacna1d

    Appenzeller, S; Balling, R; et al. De Novo Mutations in Synaptic Transmission Genes Including DNM1 Cause Epileptic Encephalopathies. AMERICAN JOURNAL OF HUMAN GENETICS 95:360-370(2014).
    Terranova, C; Tucci, M; et al. GABA Receptors Genes Polymorphisms and Alcohol Dependence: No Evidence of an Association in an Italian Male Population. CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE 12:142-148(2014).
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