galnt12

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galnt12

Official Full Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
Background This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.
Synonyms GALNT12; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12); polypeptide N-acetylgalactosaminyltransferase 12; FLJ21212; CRCS1; GalNAc T12; GalNAc-T12; GalNAcT12; GALNT 12; GLT12_HUMAN; Polypeptide GalNAc transferase 12; Polypeptide N acetylgalactosaminyltransferase 12; pp GaNTase 12; pp-GaNTase 12; Protein UDP acetylgalactosaminyltransferase 12; Protein-UDP acetylgalactosaminyltransferase 12; UDP GalNAc polypeptide N acetylgalactosaminyltransferase 12; UDP GalNAc polypeptide N acetylgalactosaminyltransferase; UDP N acetyl alpha D galactosamine polypeptide N acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; OTTHUMP00000021781; colorectal cancer, susceptibility to 1
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GALNT12-13133H Recombinant Human GALNT12, GST-tagged E.coli GST
    Human GALNT12-4692H Recombinant Human GALNT12 Protein, GST-tagged Wheat Germ GST
    Human GALNT12-681HCL Recombinant Human GALNT12 cell lysate N/A
    Rhesus Macaque GALNT12-1806R Recombinant Rhesus monkey GALNT12 Protein, His-tagged Mammalian Cell His

    galnt12 involved in several pathways and played different roles in them. We selected most pathways galnt12 participated on our site, such as Mucin type O-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with galnt12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mucin type O-Glycan biosynthesis WBSCR17; GALNT4; GALNT7; ST6GALNAC1; GALNT18A; ST3GAL1; GALNT14; C1GALT1; GALNTL4; ST3GAL2
    Metabolic pathways ODC1; ATP6V1G2; SUCLA2; NDUFS3; CYP2P9; NDUFB2; OGDHL; PLD2; RDH12; ALDOAA

    galnt12 has several biochemical functions, for example, carbohydrate binding, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by galnt12 itself. We selected most functions galnt12 had, and list some proteins which have the same functions with galnt12. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding LGALS2; OS9; CLEC11A; SIGLEC6; ZP3; KLRB1A; POC1BL; APCS; CLEC7A; LGALS3L
    metal ion binding HNRNPA0L; SDHD; ZSCAN1; ZBED3; OSR2; PLCH2; PCCA; NR1D2B; CD209; GALNT5
    polypeptide N-acetylgalactosaminyltransferase activity GALNT12; GALNT5; GALNT9; GALNT14; GALNT10; GALNT3; GALNTL4; GALNT6; GALNT7; C1GALT1C1

    galnt12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with galnt12 here. Most of them are supplied by our site. Hope this information will be useful for your research of galnt12.

    BUB1; RB1; CDH1; SRC; BMPR1A; PIK3CA; MSH2; PMS2; CDKN2A; FBXW7; MLH3

    Wang, X; Ju, LG; et al. Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:2592-2602(2014).
    Hussain, MRM; Nasir, J; et al. Clinically Significant Missense Variants in Human GALNT3, GALNT8, GALNT12, and GALNT13 Genes: Intriguing In Silico Findings. JOURNAL OF CELLULAR BIOCHEMISTRY 115:313-327(2014).

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