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GALNT12

Official Full Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)
Overview

This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.
Synonyms

GALNT12; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12); polypeptide N-acetylgalactosaminyltransferase 12; FLJ21212; CRCS1; GalNAc T12; GalNAc-T12; GalNAcT12; GALNT 12; GLT12_HUMAN; Polypeptide GalNAc transferase 12; Polypeptide N acetylgalactosaminyltransferase 12; pp GaNTase 12; pp-GaNTase 12; Protein UDP acetylgalactosaminyltransferase 12; Protein-UDP acetylgalactosaminyltransferase 12; UDP GalNAc polypeptide N acetylgalactosaminyltransferase 12; UDP GalNAc polypeptide N acetylgalactosaminyltransferase; UDP N acetyl alpha D galactosamine polypeptide N acetylgalactosaminyltransferase 12; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 12; OTTHUMP00000021781; colorectal cancer, susceptibility to 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	GALNT12-13133H	Recombinant Human GALNT12, GST-tagged	E.coli	GST	C-term-272a.a.	$319 / 25ug
Human	GALNT12-681HCL	Recombinant Human GALNT12 cell lysate		N/A		Inquiry
Human	GALNT12-4692H	Recombinant Human GALNT12 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	GALNT12-5143HF	Recombinant Full Length Human GALNT12 Protein, GST-tagged	In Vitro Cell Free System	GST	272 amino acids	Inquiry
Rhesus Macaque	GALNT12-1806R	Recombinant Rhesus monkey GALNT12 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	GALNT12-1627R	Recombinant Rhesus Macaque GALNT12 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	GALNT12-1627R-B	Recombinant Rhesus Macaque GALNT12 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
GALNT12 Related Articles
GALNT12 Related Research Area

GALNT12 involved in several pathways and played different roles in them. We selected most pathways GALNT12 participated on our site, such as Mucin type O-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALNT12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Mucin type O-Glycan biosynthesis	GCNT4A;GCNT4;C1GALT1B;GALNT6;GALNTL2;GALNT13;GALNTL1;WBSCR17;C1GALT1C1
Metabolic pathways	HYAL3;PLD1A;CYP4F3;NME2A;LDHB;SMPD2A;SMPD3;CELL;CYP11C1

GALNT12 has several biochemical functions, for example, carbohydrate binding, metal ion binding, polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GALNT12 itself. We selected most functions GALNT12 had, and list some proteins which have the same functions with GALNT12. You can find most of the proteins on our site.

Function	Related Protein
carbohydrate binding	CLEC14A;PKD1L2;MLEC;NOMO2;LGALS2A;MAN2B2;PVRL1;CANX;ILLR4
metal ion binding	ZNF230;ACACB;DMRT2;GNPTAB;ZNF792;ZFP36L1A;DDHD1B;ZBTB22;RIOK2
polypeptide N-acetylgalactosaminyltransferase activity	GALNT5;GALNT2;GALNT11;GALNT1;GALNT9;GALNT7;WBSCR17;GALNTL4;C1GALT1C1

GALNT12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALNT12 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALNT12.

BUB1; RB1; CDH1; SRC; BMPR1A; PIK3CA; MSH2; PMS2; CDKN2A; FBXW7; MLH3

Wang, X; Ju, LG; et al. Histone H3K4 methyltransferase Mll1 regulates protein glycosylation and tunicamycin-induced apoptosis through transcriptional regulation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1843:2592-2602(2014).

Hussain, MRM; Nasir, J; et al. Clinically Significant Missense Variants in Human GALNT3, GALNT8, GALNT12, and GALNT13 Genes: Intriguing In Silico Findings. JOURNAL OF CELLULAR BIOCHEMISTRY 115:313-327(2014).

Colon Cancer Biomarkers