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GALR2

  • Official Full Name

    galanin receptor 2

  • Overview

    Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
  • Synonyms

    GALR2; galanin receptor 2; galanin receptor type 2; GALNR2; GAL2-R; GALR-2; MGC125983; MGC125984;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GALR2-6028HCL Recombinant Human GALR2 293 Cell Lysate HEK293 N/A
Mouse GALR2-6198M Recombinant Mouse GALR2 Protein Mammalian Cell His
Mouse GALR2-3460M Recombinant Mouse GALR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GALR2-3460M-B Recombinant Mouse GALR2 Protein Pre-coupled Magnetic Beads HEK293
Rat GALR2-2472R Recombinant Rat GALR2 Protein Mammalian Cell His
Rat GALR2-2128R Recombinant Rat GALR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GALR2-2128R-B Recombinant Rat GALR2 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL22987HF Recombinant Full Length Human Galanin Receptor Type 2(Galr2) Protein, His-Tagged E.coli expression system His Full Length (1-387)
Mus musculus (Mouse) RFL28350MF Recombinant Full Length Mouse Galanin Receptor Type 2(Galr2) Protein, His-Tagged E.coli expression system His Full Length (1-371)
Rattus norvegicus (Rat) RFL15820RF Recombinant Full Length Rat Galanin Receptor Type 2(Galr2) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Chicken GALR2-3845C Recombinant Chicken GALR2 Mammalian Cell His
Kit-1000 Glycine Assay Kit (Fluorometric) N/A
Kit-1248 GALR2 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GALR2 Related Articles

GALR2 involved in several pathways and played different roles in them. We selected most pathways GALR2 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GALR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionNPY7R;CCKBR;BDKRB1;C3AR1;HTR5A;MC5RB;NPFFR1;TAAR7D;HTR1D

GALR2 has several biochemical functions, for example, galanin receptor activity, peptide hormone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GALR2 itself. We selected most functions GALR2 had, and list some proteins which have the same functions with GALR2. You can find most of the proteins on our site.

Function Related Protein
galanin receptor activityGAL;GALR2;GALR1;GALR3
peptide hormone bindingGHSR;ANXA5;NPR2;PTH1R;MC3R;EDNRB;GALR3;PTH1RA;RXFP2
protein bindingAZIN2;SEC23B;RPS6KA1;BMP2;OSBPL3;BCL2L13;MTPAP;SNAP91;UBTD1

GALR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GALR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GALR2.

GAL; NPY1R

Misawa, K; Misawa, Y; et al. Aberrant Methylation Inactivates Somatostatin and Somatostatin Receptor Type 1 in Head and Neck Squamous Cell Carcinoma. PLOS ONE 10:-(2015).
Metcalf, CS; Klein, BD; et al. Analgesic Properties of a Peripherally Acting and GalR2 Receptor-Preferring Galanin Analog in Inflammatory, Neuropathic, and Acute Pain Models. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 352:185-193(2015).
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