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SHC4

Official Full Name

SHC (Src homology 2 domain containing) family, member 4
Synonyms

SHC4; SHC (Src homology 2 domain containing) family, member 4; SHC-transforming protein 4; rai like protein; RaLP; hShcD; MGC34023; SH2 domain protein C4; SHC (Src homology 2 domain containing) family member 4; SHC 4; SHC; SHC family member 4; SHC transforming protein 4; SHC transforming protein D; SHCD; Src homology 2 domain containing familymember 4; Src homology 2 domain containing transforming protein C4; rai-like protein; OTTHUMP00000162250; SHC-transforming protein D; src homology 2 domain-containing-transforming protein C4;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

C
Myc
DDK
GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SHC4-2656H	Recombinant Human SHC4, GST-tagged	E.coli	GST	C-term-307aa	$319 / 25ug
Human	SHC4-1861HCL	Recombinant Human SHC4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SHC4-355H	Recombinant Human SHC4 Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	C-Myc/DDK		Inquiry
Mouse	SHC4-15093M	Recombinant Mouse SHC4 Protein	Mammalian Cell	His		Inquiry
Mouse	Shc4-5855M	Recombinant Mouse Shc4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	SHC4-8144M	Recombinant Mouse SHC4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	SHC4-8144M-B	Recombinant Mouse SHC4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
SHC4 Related Signal Pathway

SHC4 involved in several pathways and played different roles in them. We selected most pathways SHC4 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHC4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ErbB signaling pathway	AKT2;PLCG1;SOS1;NRG1;NCK2;CAMK2B1;AKT3A;MAPK10;PTK2AA
Ras signaling pathway	GNB4;INS1;PAK6;PRKACA;VEGFA;AKT1;PLA2G2E;RASAL3;ELK1
Chemokine signaling pathway	ITK;CCL3;STAT3;CCL1;GNAI2;Ccl9;CCR3;HCK;LYN
Phospholipase D signaling pathway	PDGFB;LPAR3;ARF6;PLA2G4C;GNAS;CYTH4;Pdgfa&Pdgfb;SYK;MAP2K1
Focal adhesion	SHC1;PAK2B;ROCK2;MYL12.1;VEGFAA;ITGB1;COL6A1;SEPP1;MAP2K1
Natural killer cell mediated cytotoxicity	PPP3R1;ULBP1;IFNGR2;GM-CSF;HCST;SH2D1B;KIR2DS3;IFNA8;TNFSF10
Neurotrophin signaling pathway	YWHAE;IRS1;CAMK4;TRAF6;AKT2;CAMK2D;ZFP110;MAPK13;MAPK9
Insulin signaling pathway	PPP1CAB;MKNK2A;PPP1R3CA;PYGL;BRAF;ACACA;MAPK9;INPPL1;EIF4E2RS1
Estrogen signaling pathway	CREB5;ATF6B;GABBR1;SHC2;GRB2;PLCB2;NRAS;PRKACA;ESR1
Prolactin signaling pathway	STAT5A;ESR2;SLC2A2;SOCS5;STAT1;PRL;PIK3R1;CCND1;HRAS
Alcoholism	HIST1H3E;HDAC6;HIST1H2AA;HIST1H2BB;HIST1H2AM;ATF2;HIST1H2BA;HIST1H4E;HIST3H2A
Bacterial invasion of epithelial cells	PIK3CG;CTNNA3;ACTB;PIK3R2;PXN;SEPT2;ELMO3;ITGB1;CAV2
MicroRNAs in cancer	MAPK1;CCNG1;PDCD4;TTC6;ZFPM2;CDCA5;FZD3;DICER1;GRB2
Glioma	GRB2;TP53;CAMK2B;PRKCB;PDGFB;CALML5;PTEN;PRKCA;AKT2
Chronic myeloid leukemia	PIK3R5;SOS1;SMAD3;IKBKG;TGFB1;CTBP1;PIK3CD;SHC1;MAP2K2

SHC4 has several biochemical functions, for example, protein binding, protein domain specific binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHC4 itself. We selected most functions SHC4 had, and list some proteins which have the same functions with SHC4. You can find most of the proteins on our site.

Function	Related Protein
protein binding	PLN;CUL1;TLE3;BNIP3;NFS1;PARVB;ASIC2;SMUG1;DDX21
protein domain specific binding	YWHAE1;STX1B;ABCC2;ACTN2;KCNN2;HAND2;TUBB;ARRB2;E2F4
protein kinase binding	CD24;AP1B1;PRKAG1;JIP1;MLKL;PXN;CHEK2;STK11IP;GRB7
receptor tyrosine kinase binding	DOCK4;FIZ1;PTPN14;PIK3R2;ANGPT1;SHC3;PCNA;PTPN11;PTPN1

SHC4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHC4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHC4.

EGFR; MET; AR; KIT