GFRA4
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Official Full Name
GDNF family receptor alpha 4
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Overview
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. -
Synonyms
GFRA4; GDNF family receptor alpha 4; GDNF family receptor alpha-4; persephin receptor; GDNF receptor alpha-4; GDNFR-alpha-4; GFR alpha 4; GFR receptor alpha 4; GFR-alpha-4; GFRA4_HUMAN; Glial cell line derived neurotrophic factor family receptor alpha 4; Neurotrophic factor receptor splice variant A (Gfra4 gene); OTTHUMP00000030106; OTTHUMP00000030107;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- CHO
- HEK293
- Mammalian Cell
- Flag
- His
- Fc
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | GFRA4-715H | Recombinant Human GFRA4 Protein, His-tagged | CHO | His |
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| Human | GFRA4-5951HCL | Recombinant Human GFRA4 Cell Lysate, transcript variant 1 | HEK293 | Flag |
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| Human | GFRA4-5952HCL | Recombinant Human GFRA4 Cell Lysate, transcript variant 2 | HEK293 | Flag |
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| Rat | GFRA4-2515R | Recombinant Rat GFRA4 Protein | Mammalian Cell | His |
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| Rat | GFRA4-2171R | Recombinant Rat GFRA4 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | GFRA4-2171R-B | Recombinant Rat GFRA4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Chicken | GFRA4-6549C | Recombinant Chicken GFRA4 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
GFRA4 involved in several pathways and played different roles in them. We selected most pathways GFRA4 participated on our site, such as Axon guidance, Developmental Biology, NCAM signaling for neurite out-growth, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | CNTN6;CLTA;ST8SIA2;PEA15;EFNA3B;CNTN1;PAQR3B;AGRN;SPNA2 |
| Developmental Biology | LGI2A;TRIO;KALRNB;TRPC5;PHB;LGI3;KALRN;FOXD3;ITGB3A |
| NCAM signaling for neurite out-growth | COL9A1B;PSPN;ST8SIA2;GFRA4;GFRA1;GFRA2;COL9A1A;GDNF;NRTN |
| NCAM1 interactions | COL9A1A;NRTN;GFRA4;GDNF;GFRA1;GFRA2;COL9A1B;PSPN |
GFRA4 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA4 itself. We selected most functions GFRA4 had, and list some proteins which have the same functions with GFRA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glial cell-derived neurotrophic factor receptor activity | GFRA1;GFRA2;GFRA4 |
GFRA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFRA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFRA4.
Gene Family
Research Area
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