Gna12
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Official Full Name
guanine nucleotide binding protein (G protein) alpha 12 -
Overview
RMP (RPB5-Mediating Protein), also known as URI (Unconventional prefoldin RBP5 Interactor), was described as an unconventional member of the prefoldin (PFD) family of chaperones that are involved in actin and tubulin folding. Like conventional members of -
Synonyms
GNA12;guanine nucleotide binding protein (G protein) alpha 12;guanine nucleotide-binding protein subunit alpha-12;gep;g alpha-12;WUGSC:H_GS165O14.2;G-protein subunit alpha-12;RMP;NNX3;MGC99644;MGC104623
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GNA12-7010M | Recombinant Mouse GNA12 Protein | Mammalian Cells | Mouse | His |
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| GNA12-719HCL | Recombinant Human GNA12 cell lysate | Human | Non |
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| GNA12-3753M | Recombinant Mouse GNA12 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| GNA12-3753M-B | Recombinant Mouse GNA12 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| Gna12-4277M | Recombinant Mouse Gna12 protein, His&Myc-tagged | E.coli | Mouse | His&Myc | 1-379aa |
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Involved Pathway
Gna12 involved in several pathways and played different roles in them. We selected most pathways Gna12 participated on our site, such as MAPK signaling pathway,cGMP-PKG signaling pathway,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gna12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | SHC1,TSC2,PLD2,TSC1,PDGFC,DGKD,PIK3R1,GRM7,PPAP2B,LPAR4 |
| Regulation of Actin Cytoskeleton | EGFRA,ARPC5LA,ABI2A,VCL,VAV1,PIP4K2A,RDX,BRK1,RAC1A,PPP1CBL |
| Long-term depression | BRAF,PLCB1,LYN,GNAS,NRAS,GUCY1B3,GNA11,GNAQ,PPP2R1A,PLCB4 |
| Sphingolipid signaling pathway | BCL2,AKT1,LASS5,MAPK10,OPRD1,CERS4,S1PR4,PLCB2,PPP2R5E,FCER1A |
| MAPK signaling pathway | TRAF6,PAK2A,RAF1,PPM1AA,RAC1,RRAS,PTPRR,MRAS,FGF10A,TNFRSF1A |
| Vascular smooth muscle contraction | MYL6,NPR2,GNA11A,PRKACBB,PRKCE,PLA2G2A,PRKCA,MAP2K1,CALM1B,PPP1R12A |
| Pathways in cancer | MDM2,PIK3CA,PPARG,Fasl,ITGA6,SFPI1,FADD,MTOR,ITGA2,PDGFB |
| cGMP-PKG signaling pathway | RHOA,OPRD1,ITPR3,SLC25A5,ROCK1,GTF2IRD1,PLN,ATP2A3,MAP2K2,AGTR1B |
Protein Function
Gna12 has several biochemical functions, for example, D5 dopamine receptor binding,G-protein beta/gamma-subunit complex binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gna12 itself. We selected most functions Gna12 had, and list some proteins which have the same functions with Gna12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| D5 dopamine receptor binding | GNA13B,GNA13A,GNA12A,GNA13 |
| protein binding | MAP2K6,MED12,C1D,TREML1,APOO,TRAPPC4,HELZ,TRAFD1,FAM40A,JUND |
| GTP binding | MXE,RAP1A,GIMAP2,GNL3,SEPT7A,RAB5C,NKIRAS1,SUCLG1,PCK2,SPAG1 |
| G-protein beta/gamma-subunit complex binding | GNA15.1,GNAZ,GNAIA,GNAT2,GNAI2,CETN4,GNAO1,Adcy4,GNAL,GNA11A |
| GTPase activity | RRAGA,RAB6A,EEF2B,RAB5AA,GNG3,RAB42,RAB12,RAB35B,RAB28,TUFM |
| signal transducer activity | OLFCW1,OPN1LW1,VIPR1B,CXCR4B,CXCR4A,OLFR473,STAT5B,VMN1R54,TAS2R108,OPN1MW1 |
| metal ion binding | ING5B,KEX2,TNNI3K,CYP2C38,CYGB2,NDUFS1,LYAR,ZFP354A,KDM5BA,TNNI1 |
Interacting Protein
Gna12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gna12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gna12.
PPP2R1A;IL3RA;q81v40_bacan;15-deoxy-delta(12,14;ARHGEF1
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References
- Jia, PL; Wang, LL; et al. Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia. PLOS COMPUTATIONAL BIOLOGY 8:-(2012).
- Rasheed, SAK; Teo, CR; et al. MicroRNA-182 and MicroRNA-200a Control G-protein Subunit alpha-13 (GNA13) Expression and Cell Invasion Synergistically in Prostate Cancer Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 288:7986-7995(2013).
