Gna12

  • Official Full Name

    guanine nucleotide binding protein (G protein) alpha 12
  • Overview

    RMP (RPB5-Mediating Protein), also known as URI (Unconventional prefoldin RBP5 Interactor), was described as an unconventional member of the prefoldin (PFD) family of chaperones that are involved in actin and tubulin folding. Like conventional members of
  • Synonyms

    GNA12;guanine nucleotide binding protein (G protein) alpha 12;guanine nucleotide-binding protein subunit alpha-12;gep;g alpha-12;WUGSC:H_GS165O14.2;G-protein subunit alpha-12;RMP;NNX3;MGC99644;MGC104623
Cat.# Product name Source (Host) Species Tag Protein Length Price
GNA12-7010M Recombinant Mouse GNA12 Protein Mammalian Cells Mouse His
GNA12-719HCL Recombinant Human GNA12 cell lysate Human Non
GNA12-3753M Recombinant Mouse GNA12 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GNA12-3753M-B Recombinant Mouse GNA12 Protein Pre-coupled Magnetic Beads HEK293 Mouse
Gna12-4277M Recombinant Mouse Gna12 protein, His&Myc-tagged E.coli Mouse His&Myc 1-379aa

    Involved Pathway

    Gna12 involved in several pathways and played different roles in them. We selected most pathways Gna12 participated on our site, such as MAPK signaling pathway,cGMP-PKG signaling pathway,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Gna12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Sphingolipid signaling pathway PPP2CB,ROCK1,TRAF2,NFKB1,PIK3R1,PPP2R3C,MAP2K1,FYN,PRKCZ,PPP2R3A
    Long-term depression GRIA1,PLA2G4A,PLCB4,PRKCB,MAP2K1,PLA2G4F,CRHR1,PLA2G4C,MAP2K2,IGF1R
    Phospholipase D signaling pathway Adcy4,MAP2K2,PLA2G4C,MRAS,PTK2B,PIK3CB,SPHK1,RALGDS,PLCG1,MAPK1
    Regulation of Actin Cytoskeleton ITGA11A,ITGAX,ITGA3B,CFL2,RAC2,MYL12.1,RHOA,PPP1CC,GSNA,ARHGAP35
    cGMP-PKG signaling pathway PIK3R3,MYH7,MAP2K2,PDE3A,NOS3,NPPB,RHOA,AGTR1B,ATP2A2,ATP2B4
    Vascular smooth muscle contraction PPP1R14AB,PLA2G4C,CACNA1DA,PRKCHA,NPR2,MAPK3,PRKCBA,PLCB4,ARAF,ARHGEF11
    Pathways in cancer PTEN,MMP1A,TGFB2,ITGB1,PIK3CD,GNB2,FGF13,WNT5B,TRAF4,BID
    MAPK signaling pathway MEF2C,CACNG7,FGF1B,FGF20B,RAF1,FOS,TAB2,LAMTOR3,FGF19,LRRK2

    Protein Function

    Gna12 has several biochemical functions, for example, D5 dopamine receptor binding,G-protein beta/gamma-subunit complex binding,GTP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Gna12 itself. We selected most functions Gna12 had, and list some proteins which have the same functions with Gna12. You can find most of the proteins on our site.

    Function Related Protein
    G-protein beta/gamma-subunit complex binding GNA13A,GNAZ,GNAT3,GNAV1,CETN4,GNAQ,GNA15,GNAIA,GNAI2B,GNA15.4
    signal transducer activity OLFCW1,OLFR502,OPRD1A,HTR2CL1,OLFR497,GNGT2,PTK2BB,TAS2R116,AGTR1B,GNAV1
    D5 dopamine receptor binding GNA12A,GNA13A,GNA13B,GNA13
    GTPase activity GNAT1,RAB1B,RRAGB,RAC2,TUBB2A,GNB2,RHOU,RALB,ARL1,LSG1
    GTP binding TUBA8L2,ARL4C,GNA15.4,ANXA6,RNF112,SEPT7B,ARFIP2,TUBAL3,RRAS2,NRAS
    metal ion binding WDFY3,TMPPE,ZMIZ2,GMPR,ZFP628,NEK7,PRKCH,CA5,RNF187,BCL11B
    protein binding SNRPA1,PPM1A,ZBTB33,KLHL20,PDLIM3,ORC3L,CCDC25,PROC,CDON,RHOBTB3

    Interacting Protein

    Gna12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Gna12 here. Most of them are supplied by our site. Hope this information will be useful for your research of Gna12.

    PPP2R1A;IL3RA;q81v40_bacan;15-deoxy-delta(12,14;ARHGEF1

    Resources

    References

    • Jia, PL; Wang, LL; et al. Network-Assisted Investigation of Combined Causal Signals from Genome-Wide Association Studies in Schizophrenia. PLOS COMPUTATIONAL BIOLOGY 8:-(2012).
    • Rasheed, SAK; Teo, CR; et al. MicroRNA-182 and MicroRNA-200a Control G-protein Subunit alpha-13 (GNA13) Expression and Cell Invasion Synergistically in Prostate Cancer Cells. JOURNAL OF BIOLOGICAL CHEMISTRY 288:7986-7995(2013).

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