GNAI1
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Official Full Name
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 -
Overview
Guanine nucleotide-binding protein G(i), alpha-1 subunit is a protein that in humans is encoded by the GNAI1 gene. -
Synonyms
GNAI1;guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1;guanine nucleotide-binding protein G(i) subunit alpha-1;Gi1 protein alpha subunit;adenylate cyclase-inhibiting G alpha protein;Gi
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- Mouse
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
GNAI1 involved in several pathways and played different roles in them. We selected most pathways GNAI1 participated on our site, such as Rap signaling pathway,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNAI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Gap junction | TUBA8L2,GRM1,TUBA1L,CDK1,PRKG1A,RAF1A,GNA15.1,PRKACBB,SOS1,GJD2 |
| Tight junction | CLDNE,CLDN20,MPDZ,AKT2L,MYH7B,GNAIA,RRAS2,TJP1,PTENA,KRAS |
| cAMP signaling pathway | FXYD2,RAC2,CALML3,ATP1B1,CREB5,HTR1B,TNNI3,AKT2,PRKACG,HTR4 |
| Melanogenesis | WNT9B,CALM,WNT4A,PRKCBB,FZD7A,WNT8B,WNT3,FZD10,EP300,KIT |
| Adrenergic signaling in cardiomyocytes | GNAI2A,PIK3R3A,CACNG1,RPS6KA5,CACNA1SB,PPP2R5EB,PPP2R3C,SLC9A1,ADRB2B,CACNG6A |
| Renin secretion | GNAQ,CLCA2,GNAS,CALML5,ITPR3,PPP3CC,CALM3,PDE3B,ORAI1,REN |
| Cocaine addiction | CREB3L1,SLC18A1,CDK5,PDYN,GRIN2C,DRD2,CREB5,PRKACA,GRM3,RGS9 |
| Leukocyte transendothelial migration | PTK2B,ARHGAP35,NIPAL1,TXK,CYBA,OCLN,ITGB2,MYL10,PIK3CG,MAPK13 |
| Retrograde endocannabinoid signaling | GABRG3,GABRP,ITPR3,PLCB3,MAPK12,GNAI2,GNGT2,MAPK8,GRIA3,GNGT1 |
Protein Function
GNAI1 has several biochemical functions, for example, G-protein beta/gamma-subunit complex binding,G-protein coupled serotonin receptor binding,GDP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNAI1 itself. We selected most functions GNAI1 had, and list some proteins which have the same functions with GNAI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activating protein binding | RGS14,GAPVD1,TUBB,GNAO1,PIN1,PTBP3,TSC1,PLCD1,FMNL1,CDH1 |
| protein binding | PTPN6,DCUN1D4,CFI,POLM,RIC8,BCL2L10,C17orf28,KRTAP13-3,PFDN2,MUSK |
| GTPase activity | RAB6C,RAB8A,ARFRP1,RAB6A,GBP1,MSTO1,TUBB2A,ARF6,RAB40AL,DNAJC27 |
| signal transducer activity | TAAR13C,V2RX1,GHRHRL,FLNA,OLFR5,SLC20A1,TAS2R109,CELSR1,CTNNB1,LGALS1 |
| G-protein coupled serotonin receptor binding | GNAIA,GNAO1B,GNAZ,GNAI3,GNAO1,GNAO1A |
| G-protein beta/gamma-subunit complex binding | CETN2,GNAZ,GNA11,GNAQ,GNAT1,GNA11A,Adcy4,GNA12A,GNAT3,GNAI2B |
| GDP binding | RAB3B,RAB9A,TRIM23,SEPT12,RAB11B,RAB8A,RAB7A,EIF2B1,SRP54,RAB14 |
| GTP binding | GBP3,ATL2,GTPBP6,RNGTT,RAB32,ADSSL,RAB25B,ARL8,MTG1,GNAV1 |
| metal ion binding | U2AF1L4,MKRN4,S100T,ZNF691,ATF2,BCL6AB,ROCK1,SIAH1A,ZFP335,RPE65A |
Interacting Protein
GNAI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNAI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GNAI1.
NUMA1;GPSM2;RGS17;GPSM3;RGS14;RANGAP1;MT1A;GNG2;Cbx1
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