GNPTAB
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Official Full Name
N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
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Overview
This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA. -
Synonyms
GNPTAB; N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits; GNPTA; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; KIAA1208; MGC4170; EC=2.7.8.17; GlcNAc-1-phosphotransferase subunits alpha/beta; GNPTA_HUMAN; N-acetylglucosamine-1-phosphotransferase subunit beta; Stealth protein GNPTAB; UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; GlcNAc phosphotransferase; UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosamine; glucosamine (UDP-N-acetyl)-lysosomal-enzyme N-acetylglucosamine phosphotransferase; ICD;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Mouse
- Mus musculus (Mouse)
- Zebrafish
- E.coli expression system
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Mouse | GNPTAB-7053M | Recombinant Mouse GNPTAB Protein | Mammalian Cell | His | ||
Mouse | GNPTAB-3785M | Recombinant Mouse GNPTAB Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | GNPTAB-3785M-B | Recombinant Mouse GNPTAB Protein Pre-coupled Magnetic Beads | HEK293 | |||
Danio rerio (Zebrafish) (Brachydanio rerio) | RFL18454DF | Recombinant Full Length Danio Rerio N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta(Gnptab) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (894-1219) | |
Mus musculus (Mouse) | RFL17649MF | Recombinant Full Length Mouse N-Acetylglucosamine-1-Phosphotransferase Subunits Alpha/Beta(Gnptab) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (908-1235) | |
Zebrafish | GNPTAB-3916Z | Recombinant Zebrafish GNPTAB | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- GNPTAB Related Articles
GNPTAB involved in several pathways and played different roles in them. We selected most pathways GNPTAB participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with GNPTAB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Lysosome | ATP6V0A2;LITAF;Ctsl;PSAPL1;LAMP2;NEU1;GM2A;HGSNAT;CTSK |
GNPTAB has several biochemical functions, for example, UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity, calcium ion binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GNPTAB itself. We selected most functions GNPTAB had, and list some proteins which have the same functions with GNPTAB. You can find most of the proteins on our site.
Function | Related Protein |
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UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity | GNPTG;GNPTAB |
calcium ion binding | CDHR1;SYT1B;CETN1;S100A11;SLC25A25;KCNIP1B;EHD2B;TLL1;EFCAB4B |
metal ion binding | GH1;ZNF680;GIT2;CBFA2T2;CYP2J6;PM20D1;RUFY2;FKBP8;ZNF576.2 |
transcription factor binding | CREBBP;RB1;NLRP3;FHL2;PPRC1;PPP1R13BB;TRIM11;KEAP1B;C1QBP |
transferase activity | ST6GALNAC5B;ZDHHC16B;CSNK2A2A;B3GNTL1;TGFBR1B;GBGT1L4;HGSNAT;NR5A1B;STK35L |
transferase activity, transferring phosphorus-containing groups | GNPTAB;CKMT2B;CKMT2A;CKBB;CKMB;CKMA;CKBA;CKMT1 |
GNPTAB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GNPTAB here. Most of them are supplied by our site. Hope this information will be useful for your research of GNPTAB.
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