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GRHL1

  • Official Full Name

    grainyhead-like 1 (Drosophila)

  • Overview

    This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]
  • Synonyms

    GRHL1; grainyhead-like 1 (Drosophila); MGR; NH32; LBP32; TFCP2L2; grainyhead-like protein 1 homolog; LBP protein 32; mammalian grainyhead; transcription factor LBP-32; transcription factor CP2-like 2;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRHL1-5751HCL Recombinant Human GRHL1 293 Cell Lysate HEK293 N/A
Human GRHL1-5325H Recombinant Human GRHL1 Protein, GST-tagged Wheat Germ GST
Human GRHL1-5611HF Recombinant Full Length Human GRHL1 Protein, GST-tagged In Vitro Cell Free System GST 618 amino acids
Mouse GRHL1-7253M Recombinant Mouse GRHL1 Protein Mammalian Cell His
Mouse Grhl1-3304M Recombinant Mouse Grhl1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse GRHL1-3920M Recombinant Mouse GRHL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse GRHL1-3920M-B Recombinant Mouse GRHL1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GRHL1 Related Articles

GRHL1 involved in several pathways and played different roles in them. We selected most pathways GRHL1 participated on our site, such as Fatty acid, triacylglycerol, and ketone body metabolism, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Fatty acid, triacylglycerol, and ketone body metabolismHELZ2;ACOT11;ACSF2;ACOT11B;ACOT11A;CCNC;PLIN2;SLC25A20;CDK19
MetabolismKHK;TCN1;CEPT1;SULT1C4;CHAT;SLCO1B1;SACM1LB;PPM1LA;YY2
Metabolism of lipids and lipoproteinsCYP46A1;ALOX5AP;CYP2AD6;ALOX5B.3;GRHL1;LBR;CPNE3;FIG4;MED22
PPARA activates gene expressionCTGF;MED22;PLIN2;MED7;MED8;MED29;MED16;MED9;MED20
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)MED6;MED16;MED20;MED26;MED19;MED21;MED7;MED18;PLIN2

GRHL1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, chromatin DNA binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRHL1 itself. We selected most functions GRHL1 had, and list some proteins which have the same functions with GRHL1. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingIFI203;ETV4;NR6A1;POU1F1;FOXJ1;ZNF253;SIX5;RFX5;FOXJ2
chromatin DNA bindingHDAC3;WBP2;VAX2;PER1;INSM1B;INSM1A;GRHL3;EZH2;HIST1H1D
sequence-specific DNA bindingTRP63;SREBF1;SIX2B;IKZF4;TAF2;TEFA;DMRT2A;NKX2-4;IRX6
transcription regulatory region DNA bindingSOX6;TFAP2A;SMAD6;HNF4A;ZBTB14;MZF1;GATA3;SOX5;BCL11B
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingZNF750;EGR1;NR3C1;NR1H4;FOXC2;POU2F2;ZFP639;ARNT2;TFAP2E

GRHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRHL1.

Erp44

Kohn, KW; Zeeberg, BM; et al. Gene Expression Correlations in Human Cancer Cell Lines Define Molecular Interaction Networks for Epithelial Phenotype. PLOS ONE 9:-(2014).
Fabian, J; Lodrini, M; et al. GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3. CANCER RESEARCH 74:2604-2616(2014).
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