grm4

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grm4

Official Full Name glutamate receptor, metabotropic 4
Background L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Synonyms GRM4; glutamate receptor, metabotropic 4; metabotropic glutamate receptor 4; GPRC1D; mGlu4; MGLUR4; G protein coupled receptor family C group 1 member D; G protein coupled receptor GRM4; Glutamate Receptor Metabotropic 4; GRM4_HUMAN
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRM4-5367H Recombinant Human GRM4 Protein Wheat Germ N/A
    Human GRM4-5734HCL Recombinant Human GRM4 293 Cell Lysate HEK293 N/A
    Mouse GRM4-7287M Recombinant Mouse GRM4 Protein Mammalian Cell His
    Rat GRM4-2716R Recombinant Rat GRM4 Protein Mammalian Cell His
    Cynomolgus Monkey GRM4-567C Recombinant Cynomolgus GRM4 Protein, His-tagged Mammalian Cell His
    Zebrafish GRM4-8488Z Recombinant Zebrafish GRM4 Mammalian Cell His
    Kit-1084 Albumin-to-Creatinine Ratio (ACR) Assay Kit N/A
    Kit-1335 cAMP GRM4 CHO-K1 GPCR Assay Kit N/A

    grm4 involved in several pathways and played different roles in them. We selected most pathways grm4 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with grm4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway PLCB1; GNA12; AGTR1A; CYTH2; PDGFRB; PLA2G4F; PIK3CG; LPAR2; Adcy4; INSR
    Neuroactive ligand-receptor interaction AVPR1B; GRIA2A; PTH1RA; P2RX3A; TAAR12F; PTGIR; TAAR12J; PRLHR2A; NPY1R; TAAR14F
    Glutamatergic synapse HOMER3; GNAS; GNGT1; PPP3CC; GNG5; GLS; PLA2G4F; GRIN2A; PRKCA; HOMER2
    Taste transduction GRM4; GNG13; TAS2R113; TAS2R124; TAS1R2; TAS2R136; SCNN1G; TAS1R1; PDE1A; TAS2R16

    grm4 has several biochemical functions, for example, G-protein coupled receptor activity, glutamate receptor activity, group III metabotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by grm4 itself. We selected most functions grm4 had, and list some proteins which have the same functions with grm4. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor activity TAAR12I; PRLHR; OLFR510; TAS2R138; GPR21; SMO; PPYR1; OR52B4; GPR143; GPR114
    glutamate receptor activity GRM4; GRIK5; GRM7; GRM6; GRM3; GRIA1; GRM1; GRID2; GRM2; GRIK3
    group III metabotropic glutamate receptor activity GRM8; GRM6B; GRM4; GRM6; GRM6A; GRM7

    grm4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with grm4 here. Most of them are supplied by our site. Hope this information will be useful for your research of grm4.

    Spampinato, SF; Merlo, S; et al. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. FRONTIERS IN CELLULAR NEUROSCIENCE 8:-(2015).
    Liu, F; Zhou, R; et al. METABOTROPIC GLUTAMATE RECEPTOR 5 MODULATES CALCIUM OSCILLATION AND INNATE IMMUNE RESPONSE INDUCED BY LIPOPOLYSACCHARIDE IN MICROGLIAL CELL. NEUROSCIENCE 281:24-34(2014).

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