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GRM6

Official Full Name

glutamate receptor, metabotropic 6
Overview

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8.
Synonyms

GRM6; glutamate receptor, metabotropic 6; metabotropic glutamate receptor 6; GPRC1F; mGlu6; MGLUR6; CSNB1B; DKFZp686H1993;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads
Assay Kits

Species

Human

Source

HEK293
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	GRM6-679H	Recombinant Human GRM6	Mammalian Cell	His	Inquiry
Human	GRM6-3080H	Recombinant Human GRM6 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry
Human	GRM6-5369H	Recombinant Human GRM6 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Human	GRM6-3080H-B	Recombinant Human GRM6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
	Kit-1076	p300 Inhibitor Screening Assay Kit (Fluorometric)		Non	Inquiry
	Kit-1336	cAMP GRM6 CHO-K1 GPCR Assay Kit		Non	Inquiry

Involved Pathway
Protein Function
Interacting Protein

GRM6 involved in several pathways and played different roles in them. We selected most pathways GRM6 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Phospholipase D signaling pathway	PLA2G4A;GNAS;SHC1;Adcy4;AKT2;AVPR1B;PLCB3;PIP5K1B;SHC4
Neuroactive ligand-receptor interaction	VIPR1B;TAAR14F;TAAR14J;GRIA1B;EDNRAA;HTR1AA;PRLHR2A;GABRR3;P2RX2
Glutamatergic synapse	GRM1;GNG7;SLC1A3;HOMER3;MAPK1;MAPK3;GLS2;Adcy4;GRM2

GRM6 has several biochemical functions, for example, G-protein coupled receptor activity, glutamate receptor activity, group III metabotropic glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM6 itself. We selected most functions GRM6 had, and list some proteins which have the same functions with GRM6. You can find most of the proteins on our site.

Function	Related Protein
G-protein coupled receptor activity	NPFFR1L1;MAS1;OLFCJ1;OLFR480;PTGIR;LPAR1;FZD5;OR5H1;GPR25
glutamate receptor activity	GRM5;GRM7;GRM6;GRM8;GRID2;GRM4;GRM2;GRIK3;GRM3
group III metabotropic glutamate receptor activity	GRM6B;GRM4;GRM7;GRM8;GRM6;GRM6A
protein binding	NLGN4Y;NOTCH2;PDE2A;SMARCAD1;NECAB2;AGPAT1;NT5C2;FAM118A;Ctsl
protein homodimerization activity	GM5506;ATIC;FGFR2;PVRL3;PDGFA;QPRT;DMRTC1B;GSTM3;GOT2

GRM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM6.