GRM7
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Official Full Name
glutamate receptor, metabotropic 7 -
Overview
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
GRM7;glutamate receptor, metabotropic 7;metabotropic glutamate receptor 7;GLUR7;GPRC1G;mGlu7;MGLUR7;FLJ40498;Glutamate receptor metabotropic 7;GRM7_HUMAN;OTTHUMP00000206961;OTTHUMP00000214674;OTTHUMP00000214675;OTTHUMP00000155219;OTTHUMP00000206960;OTTHUMP00000238688
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- Non
- His
- Flag
- Avi
- Fc
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| GRM7-028H |
Active Recombinant Human GRM7 Full Length Transmembrane protein(Nanodisc)
|
HEK293 | Human | Non | Full L. |
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| GRM7-2718R | Recombinant Rat GRM7 Protein | Mammalian Cells | Rat | His |
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| GRM7-7290M | Recombinant Mouse GRM7 Protein | Mammalian Cells | Mouse | His |
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| GRM7-8399Z | Recombinant Zebrafish GRM7 | Mammalian Cells | Zebrafish | His |
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| GRM7-5732HCL | Recombinant Human GRM7 293 Cell Lysate | HEK293 | Human | Non |
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| GRM7-1144HFL | Recombinant Human GRM7 protein, His&Flag-tagged | HEK293 | Human | Flag&His | 1-915 aa |
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| GRM7-2372R | Recombinant Rat GRM7 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| GRM7-2372R-B | Recombinant Rat GRM7 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| GRM7-3943M | Recombinant Mouse GRM7 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| GRM7-3943M-B | Recombinant Mouse GRM7 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| GRM7-5370H | Recombinant Human GRM7 Protein | Wheat Germ | Human | Non |
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| GRM7-5371H | Recombinant Human GRM7 Protein, GST-tagged | Wheat Germ | Human | GST |
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| GRM7-5593HF | Recombinant Full Length Human GRM7 Protein | In Vitro Cell Free System | Human | Full L. 613 amino acids |
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| GRM7-5596HF | Recombinant Full Length Human GRM7 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 915 amino acids |
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Involved Pathway
GRM7 involved in several pathways and played different roles in them. We selected most pathways GRM7 participated on our site, such as Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | KIT,GAB1,PLCB4,AGPAT4,GRM5,PIK3R3,PDGFB,PDGFRA,GNA12,SHC3 |
| Glutamatergic synapse | GRM6,SLC38A2,GNAS,SHANK2,GRIN1,HOMER2,PLA2G4A,PPP3R1,GNAI3,GRIK4 |
| Neuroactive ligand-receptor interaction | AGTR1A,PLG,HRH4,NPY5R,GRPR,GRIA2B,HTR1AB,TRHR,CSH2,P2RX2 |
Protein Function
GRM7 has several biochemical functions, for example, PDZ domain binding,adenylate cyclase inhibitor activity,calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM7 itself. We selected most functions GRM7 had, and list some proteins which have the same functions with GRM7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine binding | THNSL2,SHMT1 |
| glutamate receptor activity | GRM4,GRM3,GRIA1,GRID2,GRM8,GRM1,GRM6,GRM2,GRIK5,GRM5 |
| glutamate binding | SLC1A1,GCLC,GRIN1,SLC1A3,GLUL,GRIN2A,CPS1,GAD2,GRIK1 |
| calcium ion binding | TBC1D9B,THBS3A,CAPN1A,CACNA1SA,PDCD6,ANXA8,EGFL8,PKD2L2,PPEF2,KCNIP1B |
| PDZ domain binding | CCDC88C,GRIK2,EXOC4,ERC1,CADM1,FZD3,LLGL2,DLG1,GNG5,ATP2B3B |
| calcium channel regulator activity | SGK2A,TSPAN13,GRM2A,STIM2,GRM6A,Crisp4,NRXN3,SGK2B,NRXN2,SGK1 |
| group III metabotropic glutamate receptor activity | GRM6,GRM6A,GRM8,GRM6B,GRM4 |
| voltage-gated calcium channel activity | CACNG6,TMC1,CACNB2B,CACNA1C,CACNB4B,CACNG1,TPC3,CACNB2A,CACNA1SA,CALHM1 |
Interacting Protein
GRM7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM7.
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References
- Spampinato, SF; Merlo, S; et al. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. FRONTIERS IN CELLULAR NEUROSCIENCE 8:-(2015).
- Ullmer, C; Zoffmann, S; et al. Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7. BRITISH JOURNAL OF PHARMACOLOGY 167:1448-1466(2012).
