GRM7

  • Official Full Name

    glutamate receptor, metabotropic 7
  • Overview

    L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    GRM7;glutamate receptor, metabotropic 7;metabotropic glutamate receptor 7;GLUR7;GPRC1G;mGlu7;MGLUR7;FLJ40498;Glutamate receptor metabotropic 7;GRM7_HUMAN;OTTHUMP00000206961;OTTHUMP00000214674;OTTHUMP00000214675;OTTHUMP00000155219;OTTHUMP00000206960;OTTHUMP00000238688

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Zebrafish
  • HEK293
  • Mammalian Cells
  • In Vitro Cell Free System
  • Non
  • His
  • Flag
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
GRM7-028H Active Recombinant Human GRM7 Full Length Transmembrane protein(Nanodisc) HEK293 Human Non Full L.
GRM7-2718R Recombinant Rat GRM7 Protein Mammalian Cells Rat His
GRM7-7290M Recombinant Mouse GRM7 Protein Mammalian Cells Mouse His
GRM7-8399Z Recombinant Zebrafish GRM7 Mammalian Cells Zebrafish His
GRM7-5732HCL Recombinant Human GRM7 293 Cell Lysate HEK293 Human Non
GRM7-1144HFL Recombinant Human GRM7 protein, His&Flag-tagged HEK293 Human Flag&His 1-915 aa
GRM7-2372R Recombinant Rat GRM7 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
GRM7-2372R-B Recombinant Rat GRM7 Protein Pre-coupled Magnetic Beads HEK293 Rat
GRM7-3943M Recombinant Mouse GRM7 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
GRM7-3943M-B Recombinant Mouse GRM7 Protein Pre-coupled Magnetic Beads HEK293 Mouse
GRM7-5593HF Recombinant Full Length Human GRM7 Protein In Vitro Cell Free System Human Full L. 613 amino acids
GRM7-5596HF Recombinant Full Length Human GRM7 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 915 amino acids

    Involved Pathway

    GRM7 involved in several pathways and played different roles in them. We selected most pathways GRM7 participated on our site, such as Phospholipase D signaling pathway,Neuroactive ligand-receptor interaction,Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRM7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway PLA2G4C,MRAS,GRM4,MS4A2,PDGFB,PLCB2,GAB2,SYK,LPAR2,CYTH4
    Neuroactive ligand-receptor interaction GNRHR1,NMBR,TAAR14B,TACR1A,NPY8AR,CHRNA1,TAAR7D,PTH1RB,MC5RA,NPBWR2
    Glutamatergic synapse HOMER3,GNG4,GRIA1,GRIK1,GNB4,GNAQ,ADRBK2,PPP3CC,GRIN2A,GNAI3

    Protein Function

    GRM7 has several biochemical functions, for example, PDZ domain binding,adenylate cyclase inhibitor activity,calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRM7 itself. We selected most functions GRM7 had, and list some proteins which have the same functions with GRM7. You can find most of the proteins on our site.

    Function Related Protein
    calcium channel regulator activity PRKCB,SRI,HPCAL4,STIM1A,NRXN2,PLN,GRM6A,GNB2,SGK2A,SGK3
    calcium ion binding SLIT1,CD69,CALML3,CLSTN3,NOTCH3,PLCB4,PCDHGA2,JAG1A,DSG2,CABP7
    voltage-gated calcium channel activity CACNG1A,CACNB2,CACNG7,OPRM1,CACNB4B,CACNB2A,CACNG7A,CACNB1,CACNA2D4,CACNB4A
    glutamate binding GRIK1,GAD2,GRIN2A,GRIN1,GLUL,CPS1,SLC1A3,SLC1A1,GCLC
    PDZ domain binding SLC22A5,FZD7,ACVR2A,GNG12,ARHGEF16,FZD8,GRID2,SLC9A3,DLC,DLG1
    serine binding THNSL2,SHMT1
    group III metabotropic glutamate receptor activity GRM6A,GRM4,GRM8,GRM6,GRM6B
    glutamate receptor activity GRM5,GRM1,GRM6,GRIK5,GRM2,GRM8,GRIK3,GRIA1,GRID2,GRM4

    Interacting Protein

    GRM7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRM7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRM7.

    Resources

    References

    • Spampinato, SF; Merlo, S; et al. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. FRONTIERS IN CELLULAR NEUROSCIENCE 8:-(2015).
    • Ullmer, C; Zoffmann, S; et al. Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7. BRITISH JOURNAL OF PHARMACOLOGY 167:1448-1466(2012).

    Ask a Question for All GRM7 Products

    Required fields are marked with *

    My Review for All GRM7 Products

    Required fields are marked with *