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Official Full Name glutamate receptor, metabotropic 7
Background L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms GRM7; glutamate receptor, metabotropic 7; metabotropic glutamate receptor 7; GLUR7; GPRC1G; mGlu7; MGLUR7; FLJ40498; Glutamate receptor metabotropic 7; GRM7_HUMAN; OTTHUMP00000206961; OTTHUMP00000214674; OTTHUMP00000214675; OTTHUMP00000155219; OTTHUMP00000206960; OTTHUMP00000238688
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRM7-5370H Recombinant Human GRM7 Protein Wheat Germ N/A
    Human GRM7-5371H Recombinant Human GRM7 Protein, GST-tagged Wheat Germ GST
    Human GRM7-5732HCL Recombinant Human GRM7 293 Cell Lysate HEK293 N/A
    Mouse GRM7-7290M Recombinant Mouse GRM7 Protein Mammalian Cell His
    Rat GRM7-2718R Recombinant Rat GRM7 Protein Mammalian Cell His
    Zebrafish GRM7-8399Z Recombinant Zebrafish GRM7 Mammalian Cell His

    grm7 involved in several pathways and played different roles in them. We selected most pathways grm7 participated on our site, such as Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with grm7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phospholipase D signaling pathway INS1; PLD1; PLCB4; SHC3; AGPAT5; PDGFA; KITLG; PPAP2C; AVPR1B; IL-8
    Neuroactive ligand-receptor interaction MAS1; GRM6B; MC1R; GHRHRL; ADRB2A; HTR2A; TBXA2R; PTH1R; DRD2L; LPAR3
    Glutamatergic synapse GNGT1; SLC17A7; GRIN2A; GRIA3; GNAI1; TRPC1; SLC1A7; GNAI2; GLS; GNG4

    grm7 has several biochemical functions, for example, PDZ domain binding, adenylate cyclase inhibitor activity, calcium channel regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by grm7 itself. We selected most functions grm7 had, and list some proteins which have the same functions with grm7. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain binding DLC; PTENA; CIT; ATP2B3A; LPAR2; GRIK5; DTNA; SNTB1; GNG12; PTEN
    adenylate cyclase inhibitor activity GRM7
    calcium channel regulator activity NPY; PRKCB; TSPAN13B; HPCAL4; GRM2; SGK1; PLN; CACNA2D4; STIM1A; PRKG1
    calcium ion binding PCDH2G1; EFCAB4A; PVALB7; EFEMP2B; CCBE1; PCDHGC4; ZFP652; FBLN2; PVALB2; CDH2
    glutamate binding CPS1; GLUL; SLC1A1; GRIN1; GAD2; GRM7; GRIK1; GCLC; GRIN2A; SLC1A3
    glutamate receptor activity GRM7; GRID2; GRM5; GRIA1; GRM2; GRM3; GRM8; GRM1; GRIK5; GRM6
    group III metabotropic glutamate receptor activity GRM7; GRM6; GRM4; GRM8; GRM6B; GRM6A
    serine binding THNSL2; SHMT1; GRM7
    voltage-gated calcium channel activity CACNA1DA; CACNA2D1; CACNG2A; PKD2; CACNA2D4; TMC1; CACNA1SA; CACNG2; CACNG7A; CACNB2B

    grm7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with grm7 here. Most of them are supplied by our site. Hope this information will be useful for your research of grm7.

    Spampinato, SF; Merlo, S; et al. Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytes. FRONTIERS IN CELLULAR NEUROSCIENCE 8:-(2015).
    Ullmer, C; Zoffmann, S; et al. Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7. BRITISH JOURNAL OF PHARMACOLOGY 167:1448-1466(2012).

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