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H3F3C

Official Full Name

H3 histone, family 3C
Overview

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
Synonyms

H3F3C; H3 histone, family 3C; histone H3.3C; H3.5; histone variant H3.5;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	H3F3C-5652HCL	Recombinant Human H3F3C 293 Cell Lysate	HEK293	N/A	Inquiry
Zebrafish	H3F3C-10364Z	Recombinant Zebrafish H3F3C	Mammalian Cell	His	Inquiry
Chicken	H3F3C-3129C	Recombinant Chicken H3F3C	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

H3F3C involved in several pathways and played different roles in them. We selected most pathways H3F3C participated on our site, such as Alcoholism, Transcriptional misregulation in cancer, Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with H3F3C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Alcoholism	PRKACA;PKIA;HIST3H2BB;HIST1H2AM;HIST1H2AK;HIST1H4L;SHC2;MAP2K1;HIST2H3C
Transcriptional misregulation in cancer	MYCN;SPI1;PLAU;TLX3;HIST2H3C1;LRP2BP;JMJD1C;HMGA2;HDAC1
Systemic lupus erythematosus	HIST2H3C1;C7;H2-AB1;HIST1H2BE;HIST1H3I;HIST1H2BC;H2AFY;H2AFB3;HLA-DPA1

H3F3C has several biochemical functions, for example, nucleosomal DNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by H3F3C itself. We selected most functions H3F3C had, and list some proteins which have the same functions with H3F3C. You can find most of the proteins on our site.

Function	Related Protein
nucleosomal DNA binding	HMGA2;HMGN4;HMGN3;H3F3B;H1FOO;H3F3C;HNRNPC;H2AFY;H3F3A
protein binding	DDX20;SPINLW1;USP12;TNKS2;ARF6;LOR;PPP4R4;NUS1;PSMB1
protein heterodimerization activity	GTF2A1;MYH7;KCNIP1;ADORA2A;TAF9B;HIST1H2AG;PRPH;PVRL1;IL12A

H3F3C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with H3F3C here. Most of them are supplied by our site. Hope this information will be useful for your research of H3F3C.

NASP; PRMT5; SUV39H1; KDM1A; KDM4B; SETMAR; q8cla8_yerpe; SMYD1; PRMT6; WHSC1L1; SMYD3; PRMT7; VP24; VP24