HDAC1
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Official Full Name
histone deacetylase 1
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Overview
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008] -
Synonyms
HDAC1; histone deacetylase 1; HD1; RPD3; GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1;
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- HDAC1 Related Signal Pathway
HDAC1 involved in several pathways and played different roles in them. We selected most pathways HDAC1 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell cycle | CCND2;CENPL;E2F2;HDAC1;CDK2;MIS18A;BANF1;NUPL2;YWHAG |
| Notch signaling pathway | PSEN1;DTX3L;KAT2B;DTX4;NOTCH2;ADAM17A;HDAC2;DTX3;RBPJA |
| Thyroid hormone signaling pathway | ACTB;MED13L;NRAS;HRAS;PLCG1;PLCZ1;MED12L;ATP1B2;PLCD1 |
| Huntingtons disease | CREB3L3;SOD2;NDUFA1;Casp3;NDUFA12;UQCRH;UQCRQ;COX8A;ATP5C1 |
| Alcoholism | HIST1H2AM;HIST1H2BL;PPP1CA;SHC1;HIST1H2AA;GRIN3A;GNG3;CREB5;HIST1H2BP |
| Epstein-Barr virus infection | POLR2C;ITGAL;HDAC1;POLR3K;CSNK2A2;MAP3K14;PRKACA;HSPB1;HLA-DRB4 |
| Pathways in cancer | RARA;RARB;BMP4;TGFA;WNT2B;TP53;MET;WNT4;SMAD3 |
| Transcriptional misregulation in cancer | BMP2K;IGF1R;Aff1;NFKBIZ;HIST1H3I;CCND2;SIX4;SS18;BCL6 |
| Viral carcinogenesis | DNAJA3;GTF2H2C_2;GTF2A2;TRAF2;NRAS;ACTN1;HLA-A;HIST1H4F;HLA-C |
| MicroRNAs in cancer | NOTCH1;SOX4;VIM;MARCKS;HNRNPK;STMN1;ATM;FOXP1;Pdgfa&Pdgfb |
| Chronic myeloid leukemia | STAT5A;SMAD3;CDK6;STAT5B;RELA;NRAS;CBLC;NFKBIA;CTBP2 |
HDAC1 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC1 itself. We selected most functions HDAC1 had, and list some proteins which have the same functions with HDAC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NAD-dependent histone deacetylase activity (H3-K14 specific) | HDAC10;HDAC9;HDAC7;HDAC1;HDAC5;HDAC6;HDAC4;HDAC9B;HDAC8 |
| NF-kappaB binding | RELA;PSMA6;COMMD6;NPM1;MTDH;HSPA6;BRMS1;GSK3B;FAF1 |
| contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding | CHD4;SMARCA4;MBD3;ACTB;GATAD2B;HDAC1;SMARCB1;MTA2;SMARCC2 |
| contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding | ACTL6A;SMARCC1;ACTB;MBD3;CHD4;GATAD2B;HDAC1;RBBP4;MTA2 |
| RNA polymerase II repressing transcription factor binding | GSC;TBP;RBBP8;RBPJ;MIXL1;PROL1;BBS2;BBS5;PPARA |
| RNA polymerase II transcription corepressor activity | SOX3;SIN3B;CTBP1;HDGF;HDAC1;UXT;CITED2;ELANE;TFAP2B |
| activating transcription factor binding | RELA;HDAC7;SMAD2;PSIP1;DGKQ;EP300;TAF9;GATA4;ZFP516 |
| core promoter binding | KLF4;HDAC2;HNRNPU;IFI16;PSPC1;EZH2;AGO1;PYDC3;SFPQ |
| deacetylase activity | NDST3;HDAC1;HDAC2;NDST4;SIRT1;MACROD2;AADAC;MAPK1IP1L;C6orf130 |
| enzyme binding | TH;RCOR1;KDM1A;DIS3L;BCHE;HIST1H2AG;NOP14;SLC18A1;NOS1 |
| histone deacetylase activity | HDAC3;HDAC5;HDAC7;HDAC10;HDAC9;SIRT1;HDAC6;MTA2;HDAC8 |
| histone deacetylase binding | PARK2;RAD9A;HDAC3;SP2;RFXANK;SP1;NUDT21;SUDS3;HDAC10 |
| contributes_to nucleosomal DNA binding | GATAD2B;SMARCA4;SMARCC2;SMARCC1;SMARCB1;MBD3;HDAC2;ACTB;MTA2 |
| protein N-terminus binding | KCNQ2;ERCC4;RPS21;TBL1XR1;CSNK2A2;RPA2;NBN;GLRX;SMARCC1 |
| protein binding | OGT;C22orf23;KCNA3;TGM2;SLC35F6;MAGOHB;CCDC117;MTX2;KAT2B |
| protein deacetylase activity | SIN3A;HDAC10;SIRT2;HDAC3;HDAC4;SIRT1;HDAC1;HDAC9;HDAC2 |
| repressing transcription factor binding | MAGEA2B;PARK7;CTNNB1;MYC;MAGEA2;PRDM5;HDAC9;EIF4E;TCF3 |
| transcription factor activity, sequence-specific DNA binding | SKINT8;TFDP1B;MZF1;IRF1A;AHRRB;HMGA1A;NKX3;RFX1A;MYRFL |
| transcription factor binding | PIAS1;DRAP1;TRIB1;DDIT3;RBFOX2;RBPJ;RBL1;TAF7L;PAX6 |
| transcription regulatory region DNA binding | ATMIN;IKZF3;TCF7L2;KCNA3;ARID5B;SERPINB1A;PHB;CEBPA;SNCA |
| transcription regulatory region sequence-specific DNA binding | GATA3;EGR1;SOX11;POU2F1;FOXN1;NFE2L1B;NFE2L1;NFE2L3;PITX2 |
HDAC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC1.
HDAC2; MTA2; RBBP7
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Write a reviewThe HDAC1 proteins purchased from your company is suitable for ELISA.
The shipping was prompt enough for me to get into the experiment in the shortest time possible.
Friendly customer service and detailed answers to all the questions I asked!
Q&As (4)
Ask a questionHDAC1 is closely related to the study of diseases such as lung cancer and esophageal squamous carcinoma.
Adriamycin specifically reduces HDAC1 protein expression.
HDAC1 protein is highly expressed in esophageal squamous carcinoma tissues, and its high expression correlates with the development of esophageal squamous carcinoma.
HDAC1 is a key enzyme in the histone deacetylation process and is involved in the regulation of histone acetylation levels.
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