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Official Full Name histone deacetylase 1
Background Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]
Synonyms HDAC1; histone deacetylase 1; HD1; RPD3; GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Hi-5 Insect Cell
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Flag
    • His
    • GST
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HDAC1-549H Recombinant Human HDAC1 Protein (1-482 aa), His-SUMO-tagged E.coli His/SUMO
    Human HDAC1-1339H Recombinant Human HDAC1, His-tagged Insect Cell His
    Human HDAC1-1353H Recombinant Human HDAC1 (Active), GST-tagged Sf9 Insect Cell GST
    Human HDAC1-13703H Recombinant Human HDAC1, GST-tagged E.coli GST
    Human HDAC1-1587H Recombinant Human Histone Deacetylase 1, GST-tagged Sf9 Insect Cell GST
    Human HDAC1-27260TH Recombinant Human HDAC1 Insect Cell N/A
    Human HDAC1-29190TH Recombinant Human HDAC1 Insect Cell Flag/His
    Human HDAC1-374H Recombinant Human Histone Deacetylase 1, His-FLAG Tagged Sf9 Insect Cell His/Flag
    Human HDAC1-392H Recombinant Human Histone Deacetylase 1, His-tagged Insect Cell His
    Human HDAC1-4638H Recombinant Human HDAC1 Protein, GST-tagged Wheat Germ GST
    Human HDAC1-527H Recombinant Human HDAC1 Mammalian Cell His
    Human HDAC1-5608HCL Recombinant Human HDAC1 293 Cell Lysate HEK293 N/A
    Human HDAC1-8331H Recombinant Human HDAC1, His tagged Hi-5 Insect Cell His
    Human HDAC1-91H Recombinant Human HDAC1 Protein, FLAG/His-tagged Insect Cell Flag/His
    Mouse HDAC1-7526M Recombinant Mouse HDAC1 Protein Mammalian Cell His
    Rat HDAC1-2814R Recombinant Rat HDAC1 Protein Mammalian Cell His
    Chicken HDAC1-5732C Recombinant Chicken HDAC1 Mammalian Cell His
    Zebrafish HDAC1-9510Z Recombinant Zebrafish HDAC1 Mammalian Cell His
    Kit-1737 HDAC1 Kinetic Assay Kit N/A
    Kit-2283 HDAC1 Immunoprecipitation (IP) & Activity Assay Kit N/A

    hdac1 involved in several pathways and played different roles in them. We selected most pathways hdac1 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with hdac1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell cycle PRKDC; CP110; LIN54; YWHAQB; WRAP53; NCAPH2; SMC1B; TP53BP1; TRP53; CDC23
    Notch signaling pathway DNER; DTX2; JAG2B; ADAM17A; MFNG; TUBB3; KAT2B; LNX1; NOTCH1A; MYCBP
    Thyroid hormone signaling pathway FXYD2; PIK3R3; TRP53; PRKACB; PRKACG; PIK3CD; HIF1A; RXRG; MTOR; CASP9
    Huntingtons disease NDUFC1; DNAH5; ATP5F1; GRM5; PLCB4; POLR2F; POLR2A; CASP8; DNAH14; CREB5
    Amphetamine addiction GRIA2; CREB3L3; CAMK2G; CALM3; CALM1; GRIN2A; CREB3L1; ATF6B; MAOB; CAMK4
    Epstein-Barr virus infection VIM; LYN; TRAF6; POLR2E; YWHAH; DDX58; PSMC1; PRKACA; POLR3G; MAP3K7
    Pathways in cancer HGF; PTGER1; FZD7; Fgf15; FGF2; WNT4; MMP2; LAMA2; GNGT1; WNT6
    Transcriptional misregulation in cancer PROM1; TCF3; RARA; PTCRA; MMP3; NFKBIZ; PER2; SMAD1; HIST2H3C1; GOLPH3
    Viral carcinogenesis IKBKG; EIF2AK2; HDAC9; BAK1; PIK3CD; LTBR; PRKACB; CREB3L2; HIST1H4E; NFKBIA
    MicroRNAs in cancer ZEB1; SLC7A1; HOXD10; ATM; EZH2; MAPK1; KIF23; MET; GLS; ABCB1A
    Chronic myeloid leukemia PIK3R2; NFKB1; MAP2K1; HRAS; RELA; CBLB; ABL1; MDM2; RB1; MAPK1

    hdac1 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hdac1 itself. We selected most functions hdac1 had, and list some proteins which have the same functions with hdac1. You can find most of the proteins on our site.

    Function Related Protein
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC9; HDAC11; HDAC2; HDAC3; HDAC6; HDAC1; HDAC5; HDAC4; HDAC10; HDAC8
    NF-kappaB binding RNF25; NFKBIA; HIF1AN; RPS3; ANXA4; FAF1; COMMD7; ANKRD42; GSK3B; CPNE1
    contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding MBD3; ACTL6A; SMARCB1; MTA2; SMARCE1; GATAD2B; SMARCC2; SMARCC1; RBBP4; HDAC1
    contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding MTA2; RBBP4; HDAC1; MBD3; ACTB; SMARCC1; GATAD2B; HDAC2; SMARCC2; SMARCA4
    RNA polymerase II repressing transcription factor binding MIXL1; TCF7L2; TTC8; GATA6; GSC; RBPJ; STAT3; HDAC1; CHD4; TBX5A
    RNA polymerase II transcription corepressor activity HEYL; RERE; HDGF; NFIB; TBX15; SOX3; OLIG3; CITED2; SIN3AA; TLE1
    activating transcription factor binding DGKQ; GATA4; PSIP1; HDAC4; SMAD2; ZFP516; ATOH8; EP300; HDAC7A; HDAC7
    core promoter binding IFI203; FOXP3; MYBBP1A; ARNTL; MYOG; SFPQ; E2F3; KLF4; E2F8; SFPI1
    deacetylase activity MAPK1IP1L; NDST3; MACROD2; C6orf130; SIRT1; HDAC1; HDAC2; AADAC; NDST4; MACROD1
    enzyme binding MSH2; ATG3; PLSCR4; RCOR1; NOTCH1; MLEC; GSTM7; UGT1A3; DAOA; PHB
    histone deacetylase activity HDAC2; HDAC5; HDAC11; HDAC7; HDAC1; HDAC3; HDAC9B; HDAC8; SIRT1; MTA2
    histone deacetylase binding MAPK8; MAGEA1; ZNF703; CEBPB; TFAP4; GCM1; MECP2; NCOR1; KLF4; D7ERTD443E
    contributes_to nucleosomal DNA binding MBD3; SMARCB1; ACTB; CHD4; MTA2; SMARCE1; SMARCC2; RBBP4; GATAD2B; SMARCA4
    protein N-terminus binding KCNQ2; MYO7A; DCN; TRP53; ERCC4; GLRX; KCNIP2; STX5; RASSF1; NPAT
    protein binding GEMIN7; BCL10; IL18; ZMYM5; KIAA1737; TXN2; NUP37; ETV6; BATF; CAPNS2
    protein deacetylase activity HDAC9; HDAC1; HDAC10; HDAC3; SIN3A; HDAC4; HDAC5; HDAC2; SIRT2; SIRT1
    repressing transcription factor binding KAT5; TLE4; DDX20; SKI; CTBP1; ARNTL; HHEX; MAGEA2B; CBX5; RELA
    transcription factor activity, sequence-specific DNA binding TTC4; HIC1; POU3F2; FOXG1C; NR6A1A; NOTCH1; REST; POU3F2A; NR4A2A; LZTS1
    transcription factor binding TRAPPC2; RELA; NLRP3; PAX2; AIP; SUFU; PPP1R13BA; NR0B2; MDFIC; DNAJA3
    transcription regulatory region DNA binding ARID5A; JUN; SALL1A; DHX36; RCOR1; RBBP5; OVOL2; XRCC5; NKX3-1; RREB1
    transcription regulatory region sequence-specific DNA binding GATA1; POU2F1; NR5A1A; BACH1B; PER2; SUV39H1; SFPQ; ZNF658; HIF1AL; TBX18

    hdac1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hdac1 here. Most of them are supplied by our site. Hope this information will be useful for your research of hdac1.

    HDAC2; MTA2; RBBP7

    Kim, JH; Jee, BC; et al. Histone Acetylation Level and Histone Acetyltransferase/Deacetylase Activity in Ejaculated Sperm from Normozoospermic Men. YONSEI MEDICAL JOURNAL 55:1333-1340(2014).
    Zou, JY; Crews, FT; et al. Release of Neuronal HMGB1 by Ethanol through Decreased HDAC Activity Activates Brain Neuroimmune Signaling. PLOS ONE 9:-(2014).

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