HDAC2
-
Official Full Name
histone deacetylase 2 -
Overview
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] -
Synonyms
HDAC2;histone deacetylase 2;HD2;RPD3;YAF1;YY1-associated factor 1;transcriptional regulator homolog RPD3
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- E.coli
- Hi-5 Insect Cells
- Insect Cells
- Sf9 Cells
- Human
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Fc
- Avi
Involved Pathway
HDAC2 involved in several pathways and played different roles in them. We selected most pathways HDAC2 participated on our site, such as Cell cycle,Notch signaling pathway,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HDAC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | ABL1,TGFB3,CBLC,PTPN11,RB1,KRAS,CBL,GRB2,HRAS,NFKBIA |
| Huntingtons disease | COX6B2,SLC25A5,DCTN1,POLR2E,PLCB4,SDHD,COX7B,NDUFA2,BBC3,CASP8 |
| Notch signaling pathway | NUMBL,ADAM12,APH1B,HER15.1,NCOR2,DTX2,HER6,DLK1,DVL3A,KAT2B |
| Cell cycle | CEP135,E2F6,KIF2B,CDC23,PTTG2,NCAPG2,GSK3AA,SPC25,MCM7,GADD45AA |
| Thyroid hormone signaling pathway | ATP1B2,MED27,PLCG2,PRKACG,GSK3B,NCOA3,ITGB3,MED4,MED12,MED24 |
| Epstein-Barr virus infection | MAPK8,ITGAL,PIK3R3,EIF2AK1,RELB,XPO1,EIF2AK4,PSMC3,YWHAE,PSMD8 |
| Pathways in cancer | MSH6,AKT1,TCF7,DAPK1,WNT9A,NFKB1,WNT3,GNAI3,SKP2,MAP2K2 |
| Transcriptional misregulation in cancer | MEF2C,HIST1H3H,DOT1L,MEN1,CD86,Bcl2a1b,PDGFA,KDM6A,HPGD,SS18 |
| Alcoholism | HIST1H4N,HIST1H3F,HIST2H2BE,GM14478,HIST1H2AB,NPY,ADORA2A,HIST1H2AE,HIST1H3E,HAT1 |
Protein Function
HDAC2 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific),NF-kappaB binding,contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HDAC2 itself. We selected most functions HDAC2 had, and list some proteins which have the same functions with HDAC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| core promoter binding | GATA1,INSM1A,AGO1,CALCOCO1,NEUROG3,IFI203,SPI1,KDM3A,NPAS2,REST |
| heat shock protein binding | DNAJB6,HSPA1L,TPR,FKBP4,APAF1,DNAJA2L,DLST,BCOR,HSPA1B,SSUH2.2 |
| poly(A) RNA binding | XRCC5,SRP14,CDK11B,KCTD12,GPATCH4,UTP11L,MTDH,HEATR6,NCBP1,IFI16 |
| deacetylase activity | NDST1,C6orf130,MAPK1IP1L,NDST3,MACROD1,SIRT1,AADAC,NDST4,MACROD2,HDAC1 |
| NF-kappaB binding | CPNE1,RPS3,NFKBID,AP1S2,RELA,MTDH,DNAJA3,ANXA4,BCL10,SNAI1A |
| protein binding | DDX42,GRIA1,C16orf70,RALBP1,SLX4IP,WHSC2,CHMP1A,USP28,BBS12,EMD |
| RNA polymerase II repressing transcription factor binding | BBS5,TCERG1,TBX5A,BBS7,TTC8,BBS10,CHD4,RBPJ,PROL1,SP1 |
| sequence-specific DNA binding | FOXI3A,NKX2.3,IKZF4,ENG2A,IRX7,SALL1A,HOXB2,GATAD2AB,LHX5,CEBP1 |
| chromatin binding | HDAC3,EGR2,SLC30A9,SSRP1A,CHD7,MEIS1,ASH1L,POLA1,TP53,RBPJ |
Interacting Protein
HDAC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDAC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HDAC2.
HDAC1;SIN3A;MTA1
HDAC2 Related Signal Pathway
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References
- Lee, SH; Yoo, C; et al. Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 11:994-1000(2014).
- Scheipl, S; Lohberger, B; et al. Histone Deacetylase Inhibitors as Potential Therapeutic Approaches for Chordoma: An Immunohistochemical and Functional Analysis. JOURNAL OF ORTHOPAEDIC RESEARCH 31:1999-2005(2013).
