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Official Full Name histone deacetylase 2
Background This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]
Synonyms HDAC2; histone deacetylase 2; HD2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Hi-5 Insect Cell
    • Human
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His/GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HDAC2-163H Recombinant Human HDAC2 Protein, His-tagged Insect cell His
    Human HDAC2-1355H Recombinant Human HDAC2 (Active), GST-tagged Sf9 Insect Cell GST
    Human HDAC2-13706H Recombinant Human HDAC2, GST-tagged E.coli GST
    Human HDAC2-13707H Recombinant Human HDAC2 protein, His/GST-tagged E.coli His/GST
    Human HDAC2-13708H Recombinant Human HDAC2 protein, His-tagged E. coli His
    Human HDAC2-1590H Recombinant Human Histone Deacetylase 2, GST-tagged Sf9 Insect Cell GST
    Human HDAC2-1699H Recombinant Human Histone Deacetylase 2, His-tagged Human His
    Human HDAC2-28263TH Recombinant Human HDAC2, His-tagged Insect Cell His
    Human HDAC2-28264TH Recombinant Human HDAC2 Insect Cell N/A
    Human HDAC2-3565H Recombinant Human HDAC2, His-tagged Hi-5 Insect Cell His
    Human HDAC2-393H Recombinant Human HDAC2 protein, His-tagged Insect Cell His
    Human HDAC2-4642H Recombinant Human HDAC2 Protein, His-tagged Insect Cell His
    Human HDAC2-47H Recombinant Human HDAC2 Protein, His-tagged Insect Cell His
    Human HDAC2-5605HCL Recombinant Human HDAC2 293 Cell Lysate HEK293 N/A
    Human HDAC2-93H Recombinant Human HDAC2 Protein, GST-tagged Insect Cell GST
    Mouse HDAC2-7529M Recombinant Mouse HDAC2 Protein Mammalian Cell His
    Chicken HDAC2-6394C Recombinant Chicken HDAC2 Mammalian Cell His
    Kit-1738 HDAC2 Kinetic Assay Kit N/A
    Kit-2284 HDAC2 Immunoprecipitation (IP) & Activity Assay Kit N/A

    hdac2 involved in several pathways and played different roles in them. We selected most pathways hdac2 participated on our site, such as Cell cycle, Notch signaling pathway, Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with hdac2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Notch signaling pathway HDAC2; DNER; DTX1; DVL3A; HER15.1; NUMBL; APH1B; NOTCH4; MFAP2; KAT2A
    Thyroid hormone signaling pathway MED24; MAPK3; SLCO1C1; HDAC1; WNT4; ITGB3; ATP1B3; SLC2A1; SLC16A2; SRC
    Huntingtons disease TBPL2; GNAQ; COX7A1; COX7B; NDUFB11; PLCB1; TBPL1; COX6B1; NDUFC2-KCTD14; POLR2K
    Epstein-Barr virus infection YWHAE; BCL2; PSMD7; HSPA1A; PSMC4; HDAC1; HLA-F; EIF2AK1; PSMC1; SPI1
    Pathways in cancer GNAS; FGF4; FLT3; RXRG; CBLB; GLI2; HDAC1; SMAD3; RBX1; Pdgfa&Pdgfb
    Transcriptional misregulation in cancer MLL1; LYL1; NFKBIZ; TAF15; SPI1; PAX7; PTK2; DOT1L; BCL6; MMP9
    Viral carcinogenesis HIST1H4J; TBPL2; TRAF1; DDX3X; PIK3CA; RBL2; IL6ST; SYK; CREB5; NFKB2
    Chronic myeloid leukemia RELA; NFKBIA; TP53; TGFBR1; KRAS; RUNX1; BCL2L1; CTBP2; PIK3CG; TGFB1

    hdac2 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), NF-kappaB binding, contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hdac2 itself. We selected most functions hdac2 had, and list some proteins which have the same functions with hdac2. You can find most of the proteins on our site.

    Function Related Protein
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC3; HDAC8; HDAC10; HDAC7A; HDAC11; HDAC2; HDAC9B; HDAC9; HDAC7; HDAC4
    NF-kappaB binding ANXA4; COMMD7; NFKBID; BCL10; HIF1AN; SNAI1A; RPS3; CDKN2A; HDAC2; FAF1
    contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding ACTB; RBBP4; SMARCB1; MTA2; SMARCC2; SMARCC1; ACTL6A; MBD3; GATAD2B; HDAC2
    contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding SMARCE1; HDAC2; MBD3; SMARCC1; SMARCB1; SMARCC2; ACTB; MTA2; CHD4; SMARCA4
    RNA polymerase II repressing transcription factor binding SIN3A; PROL1; MKKS; RBPJ; DMAP1; BBS2; PPARA; MTA1; SP1; BBS1
    chromatin binding RING1; PAF1; TOP2A; MB21D2; SOX9; SOD3; RELB; HMGB3; JARID2B; DNMT3A
    core promoter binding HMGA2; INSM1A; SPI1; EZH2; NKX2-1; HDAC5; NPAS2; ARNTL; E2F7; NEUROG3
    deacetylase activity NDST3; MAPK1IP1L; AADAC; MACROD1; C6orf130; SIRT1; HDAC2; NDST4; MACROD2; NDST1
    enzyme binding GSTM2; UGT1A4; BCL10; TNKS2; HSPA8; CTNNB1; TBP; RFC5; CUTA; UGT1A3
    heat shock protein binding PDXP; KCNJ11; NFKB1; NFKBIA; FAF1; APAF1; DNAJA3B; FKBP4; EEF1D; DNAJC9
    histone deacetylase activity SIRT1; MTA2; HDAC9B; HDAC2; HDAC6; HDAC1; HDAC3; HDAC7; HDAC10; HDAC8
    contributes_to nucleosomal DNA binding CHD4; SMARCA4; RBBP4; MBD3; GATAD2B; ACTL6A; SMARCC2; HDAC1; SMARCB1; MTA2
    poly(A) RNA binding TBRG4; TPR; SSBP1; MRPS12; SRSF4; TRNAU1AP; CCBL2; HNRNPU; ESF1; GNL3
    protein binding ZMYND19; NEK11; PYGL; RERG; CTSD; EPHB6; ADI1; PARP1; IFI30; POGK
    protein deacetylase activity HDAC3; HDAC2; HDAC9; HDAC10; HDAC1; HDAC4; SIRT1; HDAC5; SIN3A; SIRT2
    sequence-specific DNA binding LMX1BB; FOXF2A; HOXD9A; ZBTB33; ZFP161; FOXP2; PPARAA; MNX1; PKNOX1.1; TCF7L1A
    transcription factor binding PAX2; TNFRSF10A; ERCC3; DNAJA3; EP300; FOXA2; AHR; TFDP1A; NAAA; MYOD1

    hdac2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hdac2 here. Most of them are supplied by our site. Hope this information will be useful for your research of hdac2.

    HDAC1; SIN3A; MTA1

    Lee, SH; Yoo, C; et al. Expression of Histone Deacetylases in Diffuse Large B-cell Lymphoma and Its Clinical Significance. INTERNATIONAL JOURNAL OF MEDICAL SCIENCES 11:994-1000(2014).
    Scheipl, S; Lohberger, B; et al. Histone Deacetylase Inhibitors as Potential Therapeutic Approaches for Chordoma: An Immunohistochemical and Functional Analysis. JOURNAL OF ORTHOPAEDIC RESEARCH 31:1999-2005(2013).

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