Recombinant Human HDAC2, GST-tagged

• Cat.No.: HDAC2-13706H
• Product Overview: Recombinant Human HDAC2 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-term-299a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HDAC2 histone deacetylase 2 [ Homo sapiens ]
• Official Symbol: HDAC2
• Synonyms: HDAC2; histone deacetylase 2; RPD3; YAF1; YY1-associated factor 1; transcriptional regulator homolog RPD3; HD2
• Gene ID: 3066
• mRNA Refseq: NM_001527
• Protein Refseq: NP_001518
• MIM: 605164
• UniProt ID: Q92769
• Chromosome Location: 6q21
• Pathway: Cell cycle, organism-specific biosystem; Cell cycle, organism-specific biosystem; Cell cycle, conserved biosystem; Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem
• Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); chromatin binding; enzyme binding; histone deacetylase activity; histo

Reviews

11/23/2021

Its versatility allows for its successful implementation in diverse areas such as molecular biology, cellular assays, and protein-protein interactions.

11/16/2018

This adaptability ensures that the HDAC2 protein can effectively address my specific research objectives, enabling breakthrough discoveries.

08/22/2018

the HDAC2 protein exhibits superior performance across a range of experimental applications.

Q&As

Can HDAC2 be a potential biomarker for certain diseases?

Research suggests that HDAC2 levels can serve as a biomarker for certain diseases, aiding in diagnosis and prognosis.

Are there HDAC inhibitors used in clinical settings?

Yes, HDAC inhibitors are being explored as a therapeutic strategy in cancer treatment, aiming to block the activity of HDAC2.

How does HDAC2 impact cancer progression?

HDAC2 is often overexpressed in cancer cells, contributing to uncontrolled cell growth and survival.

How does HDAC2 influence cellular processes through histone deacetylation?

HDAC2 removes acetyl groups from histones, leading to chromatin condensation and repression of gene transcription, affecting cellular processes.

How does HDAC2 relate to neurodegenerative disorders?

HDAC2 dysregulation has been observed in neurodegenerative diseases, suggesting a role in the pathogenesis of conditions like Alzheimer's.