Recombinant Human HDAC2 Protein, His-tagged

• Cat.No.: HDAC2-47H
• Product Overview: Recombinant human HDAC2 protein with a C-terminal His-tag was expressed in baculovirus expression vector system.

Specification

• Description: This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
• Source: Insect cells
• Species: Human
• Tag: His
• Molecular Mass: 56 kDa
• Purity: ≥90% estimated by SDS-PAGE
• Unit Definition: One unit is the amount of enzyme required to release 1 pmol of acetate per minute at 37 centigrade in 25 mM Tris-HCl, pH 8.0, with 137 mM sodium chloride, 2.7 mM potassium chloride, 1 mM magnesium chloride, 0.1 mg/mL BSA, and 20 μM fluorogenic HDAC substrate 3.
• Applications: Enzyme Activity, WB, ELISA
• Stability: ≥ 6 months
• Storage: Store it at -80 centigrade
• Storage Buffer: 40 mM Tris-HCl, pH 8.0, with 110 mM sodium chloride, 2.2 mM potassium chloride, 20% glycerol, and 200 mM imidazole

Gene Information

• Gene Name: HDAC2 histone deacetylase 2 [ Homo sapiens (human) ]
• Official Symbol: HDAC2
• Synonyms: HDAC2; histone deacetylase 2; HD2; RPD3; YAF1; KDAC2; histone deacetylase 2; YY1-associated factor 1; transcriptional regulator homolog RPD3
• Gene ID: 3066
• mRNA Refseq: NM_001527
• Protein Refseq: NP_001518
• MIM: 605164
• UniProt ID: Q92769