Recombinant Human HDAC2 (1-488)-HIS (digested with Trypsin) Protein

• Cat.No.: HDAC212813H

Specification

• Description: HDAC2 was expressed and purified from insect cells. The protein was expressed as a HIS-fusion protein and purified by a 3-step chromatographic procedure comprising affinity and size exclusion chromatography steps including partial proteolysis by trypsin.
• Species: Human
• Molecular Mass: 44 kDa
• Purity: > 95%
• Storage: frozen; -80
• Storage Buffer: 25 mM TRIS 7.6;250 mM NaCl;0.125 mM TCEP

Gene Information

• Gene Name: HDAC2 (1-488)-HIS (digested with Trypsin)
• Official Symbol: HDAC2
• Synonyms: HD3; RPD3; RPD3-2; histone deacetylase 3
• Gene ID: 3066
• UniProt ID: Q92769

Reviews

11/23/2021

Its versatility allows for its successful implementation in diverse areas such as molecular biology, cellular assays, and protein-protein interactions.

11/16/2018

This adaptability ensures that the HDAC2 protein can effectively address my specific research objectives, enabling breakthrough discoveries.

08/22/2018

the HDAC2 protein exhibits superior performance across a range of experimental applications.

Q&As

Can HDAC2 be a potential biomarker for certain diseases?

Research suggests that HDAC2 levels can serve as a biomarker for certain diseases, aiding in diagnosis and prognosis.

Are there HDAC inhibitors used in clinical settings?

Yes, HDAC inhibitors are being explored as a therapeutic strategy in cancer treatment, aiming to block the activity of HDAC2.

How does HDAC2 impact cancer progression?

HDAC2 is often overexpressed in cancer cells, contributing to uncontrolled cell growth and survival.

How does HDAC2 influence cellular processes through histone deacetylation?

HDAC2 removes acetyl groups from histones, leading to chromatin condensation and repression of gene transcription, affecting cellular processes.

How does HDAC2 relate to neurodegenerative disorders?

HDAC2 dysregulation has been observed in neurodegenerative diseases, suggesting a role in the pathogenesis of conditions like Alzheimer's.