HDGF

  • Official Full Name

    hepatoma-derived growth factor

  • Overview

    This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms

    HDGF; hepatoma-derived growth factor; hepatoma derived growth factor (high mobility group protein 1 like); high mobility group protein 1 like; HMG1L2; HMG-1L2; high mobility group protein 1-like 2; FLJ96580; DKFZp686J1764;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • GMP Proteins
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • GST
  • His
  • Fc
  • Avi
  • Myc
  • T7
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HDGF-4658H Recombinant Human HDGF Protein, GST-tagged Wheat Germ GST
Human HDGF-29209TH Recombinant Human HDGF E.coli Non 1-100
Human HDGF-361H Recombinant Human HDGF E.coli Non
Human HDGF-27530TH Recombinant Human HDGF E.coli Non 100 amino acids
Human HDGF-620H Recombinant Human HDGF protein, His & T7-tagged E.coli His&T7 Tyr10~Leu240
Human HDGF-5598HCL Recombinant Human HDGF 293 Cell Lysate HEK293 Non
Human HDGF-3439HF Recombinant Full Length Human HDGF Protein, GST-tagged In Vitro Cell Free System GST 240 amino acids
Human HDGF-2714H Recombinant Human HDGF Protein (Tyr10-Leu240), N-His tagged E.coli His Tyr10-Leu240
Human HDGF-139H Recombinant Human HDGF Protein (Met1-Leu240), C-His tagged, Animal-free, Carrier-free E.coli His Met1-Leu240
Human HDGF-1052H Recombinant Human HDGF Protein, His-tagged E.coli His
Human HDGF-2784H Recombinant Human HDGF protein(71-150 aa), C-His-tagged E.coli His 71-150 aa
Human HDGF-159H Recombinant Human HDGF Protein, His-tagged E.coli His Met1-Tyr100
Mouse Hdgf-75M Recombinant Mouse Hdgf protein, His-tagged E.coli His Asp14~Gly187
Mouse HDGF-7539M Recombinant Mouse HDGF Protein Mammalian Cell His
Mouse HDGF-4097M-B Recombinant Mouse HDGF Protein Pre-coupled Magnetic Beads HEK293
Mouse Hdgf-36M Recombinant Mouse Hdgf Protein (Met1-Leu237), C-His tagged, Animal-free, Carrier-free E.coli His Met1-Leu237
Mouse HDGF-2277M Recombinant Mouse HDGF Protein (1-237 aa), His-Myc-tagged Yeast His&Myc 1-237 aa
Mouse Hdgf-01M GMP Recombinant Mouse Hdgf Protein, His-Tagged E.coli His
Mouse HDGF-4097M Recombinant Mouse HDGF Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Rat HDGF-2819R Recombinant Rat HDGF Protein Mammalian Cell His
Rat HDGF-2474R Recombinant Rat HDGF Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Rat HDGF-2474R-B Recombinant Rat HDGF Protein Pre-coupled Magnetic Beads HEK293
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is HDGF protein?

HDGF (hepatoma-derived growth factor) protein is a nuclear protein that is highly conserved across species. It was originally identified as a growth factor secreted by hepatoma cells, but it is now known to have diverse functions in various cellular processes.

The HDGF protein is involved in cell proliferation, migration, and differentiation. It functions as a transcriptional coactivator and can interact with various transcription factors to regulate gene expression. HDGF has also been shown to have a role in DNA repair and chromatin remodeling.

What is the function of HDGF protein?

The HDGF (Hepatoma-derived growth factor) protein is a nuclear protein that plays a role in various cellular processes, including cell proliferation, cell migration, and angiogenesis. It functions as a transcriptional co-activator and binds to specific DNA sequences to regulate gene expression. HDGF is also involved in DNA repair and chromatin remodeling, indicating its role in maintaining genomic stability. Additionally, HDGF has been implicated in cancer progression and metastasis due to its pro-angiogenic and pro-tumorigenic properties.

HDGF related signaling pathway

PI3K/Akt/mTOR pathway: HDGF activates the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, which promotes cell survival, proliferation, and angiogenesis.

Ras/ERK pathway: HDGF activates the Ras/Raf/extracellular signal-regulated kinase (ERK) signaling pathway, leading to the promotion of cell proliferation and migration.

Wnt/β-catenin pathway: HDGF has been shown to promote Wnt signaling by enhancing the nuclear accumulation and transcriptional activity of β-catenin, which plays a critical role in cell proliferation and cancer development.

HDGF Related Diseases

  •  Cancer: HDGF has been found to be overexpressed in various types of cancer, including hepatocellular carcinoma, pancreatic cancer, breast cancer, and glioma. It promotes tumor growth, invasion, and metastasis by stimulating cell proliferation, angiogenesis, and epithelial-mesenchymal transition.
  •  Cardiovascular diseases: HDGF has been implicated in cardiovascular diseases such as atherosclerosis and cardiac hypertrophy. It is involved in promoting smooth muscle cell proliferation and migration, leading to the development of atherosclerotic plaques. Additionally, HDGF is upregulated in response to cardiac injury and contributes to cardiac remodeling and hypertrophy.
  •  Neurological disorders: HDGF is involved in promoting neuronal survival, differentiation, and regeneration. It has been suggested to play a role in neurological disorders such as stroke and Alzheimer's disease. HDGF expression is increased in response to brain injury and contributes to neuronal repair and regeneration.
  •  Neurological disorders: HDGF is involved in promoting neuronal survival, differentiation, and regeneration. It has been suggested to play a role in neurological disorders such as stroke and Alzheimer's disease. HDGF expression is increased in response to brain injury and contributes to neuronal repair and regeneration.

Biomedical Application of HDGF Protein

The High Mobility Group Box 1 (HMGB1) protein is a nuclear protein that functions as a transcription factor and plays a role in DNA repair. It is also released into the extracellular environment in response to tissue damage or stress, where it acts as a pro-inflammatory cytokine. HMGB1 has been implicated in several diseases, including cancer, autoimmune diseases, and neurodegenerative disorders. It has also been explored as a potential therapeutic target for the treatment of these conditions.

High Purity

HDGF

Fig1. SDS-PAGE (HDGF-4658H)

HDGF

(Bo Sun, 2015)

Fig2. miR-610 down-regulates HDGF expression by directly targeting its 3'UTR. A. Schematic representation of the construction of wild-type or mutant HDGF 3'UTR vector.

HDGF

(Xuemin Liang, 2021)


Fig3. Direct interaction of NAP1L1 and HDGF. (A) Immunofluorescence microscopy of NAP1L1, HDGF, and DAPI localization in colon cancer cells.


HDGF

(Zhen Liu, 2019)

Fig4. miR-3619-5p targeted both LINC00342 and hepatoma-derived growth factor (HDGF) in hemangioma-derived endothelial cells (HemECs). the protein level of HDGF in HemECs transfected with miR-3619-5p mimics and miR-3619-5p inhibitors or their respective negative controls were detected by Western blot analysis.

HDGF involved in several pathways and played different roles in them. We selected most pathways HDGF participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with HDGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
IRE1alpha activates chaperonesCXXC1;KLHDC3;SEC63;SEC61B;PREB;YIF1A;CTDSP2;HYOU1;C19orf10
Metabolism of proteinsNAT8;IGFBP5B;SERPINA7;EID3;IGFBP6B;GAS6;TPP1;LDHD;BET1
Unfolded Protein Response (UPR)YIF1A;TPP1;SERP1;ASNA1;CTDSP2;WIPI1;SEC63;HDGF;DDX11
XBP1(S) activates chaperone genesDNAJB9;C19orf10;HDGF;CXXC1;WIPI1;DDX11;SERP1;KDELR3;PDIA6

HDGF has several biochemical functions, for example, DNA binding, RNA polymerase II transcription corepressor activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HDGF itself. We selected most functions HDGF had, and list some proteins which have the same functions with HDGF. You can find most of the proteins on our site.

Function Related Protein
DNA bindingNOSTRIN;GPBP1L1;ZFP280D;SUPV3L1;SPHK1;TBX10;DRGX;SMYD1;Alb
RNA polymerase II transcription corepressor activityELANE;TLE1;HDAC1;TBX18;CITED2;SIN3A;HDGF;CTBP1;OLIG3
growth factor activityCOL20A1;LIF;IGF2;FGF20B;SPAW;GPI1;FGF11A;FGF10;IGF1
heparin bindingSOST;NRP2;NRP1A;COL13A1;BSPH1;PTPRF;AAMP;PCOLCE;ADAMTS8
nucleotide bindingPRKCHA;TRMT2A;SRSF3;HSP90AA1.1;GDPGP1;CSF1RA;NT5C3L;SRPK1B;RHOT1A
poly(A) RNA bindingHNRNPA1;RPS15A;AGO3;U2SURP;LSM14A;CHST13;PRRC2A;SRP54;SLC25A11
transcription corepressor bindingFAM89B;HDGF;SIX3;RORA;NR1D1

HDGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDGF here. Most of them are supplied by our site. Hope this information will be useful for your research of HDGF.

DDX5; SRSF1; SSRP1; HDAC1; PARP1; PRKDC

Research Area

Related articles

Kang, S; Xiao, G; et al. Proteomics analysis of altered cellular metabolism induced by insufficient copper level. JOURNAL OF BIOTECHNOLOGY 189:15-26(2014).
Zhao, J; Ma, MZ; et al. Anti-HDGF Targets Cancer and Cancer Stromal Stem Cells Resistant to Chemotherapy. CLINICAL CANCER RESEARCH 19:3567-3576(2013).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
03/30/2021

    It demonstrates excellent performance in ELISA, consistently delivering accurate and reliable results.

    06/25/2020

      I highly recommend the HDGF protein for a variety of research applications.

      01/03/2020

        The HDGF protein has proven to be an invaluable tool in protein electron microscopy structure analysis.

        Q&As (5)

        Ask a question
        Are there any side effects associated with HDGF-targeted therapies? 05/29/2022

        The potential side effects of HDGF-targeted therapies are still under investigation, and research aims to minimize any adverse effects.

        Can HDGF-targeted therapies be personalized for individual patients? 01/08/2019

        Personalized HDGF-targeted therapies are an area of research interest, with efforts to identify patient-specific variations in HDGF expression.

        How does HDGF impact cardiovascular health? 04/12/2017

        HDGF has been implicated in cardiovascular diseases, where it plays a role in angiogenesis and tissue repair, making it a potential therapeutic target for heart-related conditions.

        Is HDGF involved in tissue regeneration? 09/07/2016

        Yes, HDGF is involved in tissue regeneration by promoting cell growth and supporting the repair of damaged tissues.

        How does HDGF interact with other proteins in cellular processes? 07/24/2016

        HDGF interacts with various proteins involved in cell signaling, growth, and survival pathways, influencing cellular processes.

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