HDGF
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Official Full Name
hepatoma-derived growth factor -
Overview
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
HDGF;hepatoma-derived growth factor;hepatoma derived growth factor (high mobility group protein 1 like);high mobility group protein 1 like;HMG1L2;HMG-1L2;high mobility group protein 1-like 2;FLJ96580;DKFZp686J1764
Recombinant Proteins
- Mouse
- Human
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Yeast
- In Vitro Cell Free System
- His
- Non
- GST
- T7
- Myc
- Avi
- Fc
Background
What is HDGF protein?
HDGF (hepatoma-derived growth factor) protein is a nuclear protein that is highly conserved across species. It was originally identified as a growth factor secreted by hepatoma cells, but it is now known to have diverse functions in various cellular processes.
The HDGF protein is involved in cell proliferation, migration, and differentiation. It functions as a transcriptional coactivator and can interact with various transcription factors to regulate gene expression. HDGF has also been shown to have a role in DNA repair and chromatin remodeling.
What is the function of HDGF protein?
The HDGF (Hepatoma-derived growth factor) protein is a nuclear protein that plays a role in various cellular processes, including cell proliferation, cell migration, and angiogenesis. It functions as a transcriptional co-activator and binds to specific DNA sequences to regulate gene expression. HDGF is also involved in DNA repair and chromatin remodeling, indicating its role in maintaining genomic stability. Additionally, HDGF has been implicated in cancer progression and metastasis due to its pro-angiogenic and pro-tumorigenic properties.
HDGF related signaling pathway
PI3K/Akt/mTOR pathway: HDGF activates the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway, which promotes cell survival, proliferation, and angiogenesis.
Ras/ERK pathway: HDGF activates the Ras/Raf/extracellular signal-regulated kinase (ERK) signaling pathway, leading to the promotion of cell proliferation and migration.
Wnt/β-catenin pathway: HDGF has been shown to promote Wnt signaling by enhancing the nuclear accumulation and transcriptional activity of β-catenin, which plays a critical role in cell proliferation and cancer development.
HDGF Related Diseases
- Cancer: HDGF has been found to be overexpressed in various types of cancer, including hepatocellular carcinoma, pancreatic cancer, breast cancer, and glioma. It promotes tumor growth, invasion, and metastasis by stimulating cell proliferation, angiogenesis, and epithelial-mesenchymal transition.
- Cardiovascular diseases: HDGF has been implicated in cardiovascular diseases such as atherosclerosis and cardiac hypertrophy. It is involved in promoting smooth muscle cell proliferation and migration, leading to the development of atherosclerotic plaques. Additionally, HDGF is upregulated in response to cardiac injury and contributes to cardiac remodeling and hypertrophy.
- Neurological disorders: HDGF is involved in promoting neuronal survival, differentiation, and regeneration. It has been suggested to play a role in neurological disorders such as stroke and Alzheimer's disease. HDGF expression is increased in response to brain injury and contributes to neuronal repair and regeneration.
- Neurological disorders: HDGF is involved in promoting neuronal survival, differentiation, and regeneration. It has been suggested to play a role in neurological disorders such as stroke and Alzheimer's disease. HDGF expression is increased in response to brain injury and contributes to neuronal repair and regeneration.
Biomedical Application of HDGF Protein
The High Mobility Group Box 1 (HMGB1) protein is a nuclear protein that functions as a transcription factor and plays a role in DNA repair. It is also released into the extracellular environment in response to tissue damage or stress, where it acts as a pro-inflammatory cytokine. HMGB1 has been implicated in several diseases, including cancer, autoimmune diseases, and neurodegenerative disorders. It has also been explored as a potential therapeutic target for the treatment of these conditions.
Case Study
(Bo Sun, 2015)
Fig2. miR-610 down-regulates HDGF expression by directly targeting its 3'UTR. A. Schematic representation of the construction of wild-type or mutant HDGF 3'UTR vector.
(Xuemin Liang, 2021)
Fig3. Direct interaction of NAP1L1 and HDGF. (A) Immunofluorescence microscopy of NAP1L1, HDGF, and DAPI localization in colon cancer cells.
(Zhen Liu, 2019)
Fig4. miR-3619-5p targeted both LINC00342 and hepatoma-derived growth factor (HDGF) in hemangioma-derived endothelial cells (HemECs). the protein level of HDGF in HemECs transfected with miR-3619-5p mimics and miR-3619-5p inhibitors or their respective negative controls were detected by Western blot analysis.
Quality Guarantee
High Purity
Fig1. SDS-PAGE (HDGF-4658H)
Involved Pathway
HDGF involved in several pathways and played different roles in them. We selected most pathways HDGF participated on our site, such as IRE1alpha activates chaperones,Metabolism of proteins,Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with HDGF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IRE1alpha activates chaperones | SERP1,CTDSP2,ADD1,KLHDC3,ASNA1,YIF1A,SEC63,TPP1,DDX11,PREB |
| XBP1(S) activates chaperone genes | DDX11,PDIA6,SEC63,TPP1,C19orf10,WIPI1,YIF1A,ASNA1,KLHDC3,KDELR3 |
| Metabolism of proteins | PIGK,PAPPA2,ARSD,PPP6R1,ARSE,IGFBP2A,NEU4,EXOSC8,PFDN2,SSPO |
| Unfolded Protein Response (UPR) | DDX11,SEC63,FKBP14,WIPI1,YY2,DNAJB9,C19orf10,KLHDC3,PDIA6,ASNA1 |
Protein Function
HDGF has several biochemical functions, for example, DNA binding,RNA polymerase II transcription corepressor activity,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HDGF itself. We selected most functions HDGF had, and list some proteins which have the same functions with HDGF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | ROCK2,THRAP3,PURA,MRPL14,MACF1,ZC3H18,PNO1,SRSF7,RPS21,DHX35 |
| heparin binding | GM4980,FGF12,FMODA,GPNMB,ANG,CCDC80,SLIT1B,PRELP,TENM1,ZNF207 |
| transcription corepressor binding | NR1D1,RORA,SIX3,FAM89B |
| DNA binding | HIST1H2BK,H3F3B.1,IRF3,POLR2I,PIN4,HNF4A,AHR,TRIM27,FOXD1L,SPI1B |
| RNA polymerase II transcription corepressor activity | UXT,HDAC1,SIN3AA,RBBP8,HEYL,NFIB,ELANE,SIN3B,CTBP1,TFAP2B |
| nucleotide binding | ZRANB3,TUBA1L2,MYHZ2,ZRSR2,SMG1,RBM18,GTF2F2B,SMYHC1,DHX32A,GM4922 |
| growth factor activity | MSTN,GDF5,PDGFAB,MDKB,CD320,OGN,TGFB1,NRTN,NTF4,PTN |
Interacting Protein
HDGF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HDGF here. Most of them are supplied by our site. Hope this information will be useful for your research of HDGF.
DDX5;SRSF1;SSRP1;HDAC1;PARP1;PRKDC
Resources
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References
- Kang, S; Xiao, G; et al. Proteomics analysis of altered cellular metabolism induced by insufficient copper level. JOURNAL OF BIOTECHNOLOGY 189:15-26(2014).
- Zhao, J; Ma, MZ; et al. Anti-HDGF Targets Cancer and Cancer Stromal Stem Cells Resistant to Chemotherapy. CLINICAL CANCER RESEARCH 19:3567-3576(2013).
