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Official Full Name hairy/enhancer-of-split related with YRPW motif-like
Background Heyl is a member of the Hairy/ Enhancer of split (E(spl))-related with YRPW motif (Hey) genes, which are a subfamily of mammalian (E(spl))-related basic helix-loop-helix (bHLH) genes that encode a carboxy-terminal KPYRPWG sequence3. The proteins are also
Synonyms HEYL; hairy/enhancer-of-split related with YRPW motif-like; hairy/enhancer-of-split related with YRPW motif-like protein; bHLHb33; hairy/enhancer of split related with YRPW motif 3; HEY3; HRT-3; hHRT3; hHeyL; HEY-like protein; hairy-related transcription
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HEYL-13757H Recombinant Human HEYL, His-tagged E.coli His
    Human HEYL-4719H Recombinant Human HEYL Protein, GST-tagged Wheat Germ GST
    Human HEYL-5573HCL Recombinant Human HEYL 293 Cell Lysate HEK293 N/A
    Mouse HEYL-7600M Recombinant Mouse HEYL Protein Mammalian Cell His
    Zebrafish HEYL-9634Z Recombinant Zebrafish HEYL Mammalian Cell His

    heyl involved in several pathways and played different roles in them. We selected most pathways heyl participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants, Constitutive Signaling by NOTCH1 PEST Domain Mutants, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with heyl were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants MIB1; HEY2; JAG1; HDAC6; ADAM10; CDK8; CCNC; HEY1; HEYL; HDAC5
    Constitutive Signaling by NOTCH1 PEST Domain Mutants JAG2; JAG1; HEY1; MIB1; HEY2; CCNC; HEYL; ADAM10; CDK8; HDAC6
    Disease KPNA3; CTDP1; CDC37; NUP50; DERL2; AP2M1; RLBP1; PACS1; NMT1; LRRFIP1
    Diseases of signal transduction DERL2; HEY1; JAG2; RLBP1; CPSF6; HDAC5; FKBP1A; MIB1; STRA6; LRRFIP1
    NOTCH1 Intracellular Domain Regulates Transcription HEYL; TUBB3; HEY2; TLE1; HEY1; TLE3; TLE4; TLE2
    Signal Transduction OXGR1A.3; RBP4; CHRDL1; METAP2B; F11R.2; ARHGAP40; GPR161; ARHGEF1B; TAS2R3; OPN5
    Signaling by NOTCH MDKA; DLK1; TLE4; MDK; DTX2; RAB6A; DNER; TLE3; MDKB; TLE2
    Signaling by NOTCH1 TLE3; DTX2; HEYL; DLK1; DNER

    heyl has several biochemical functions, for example, AF-1 domain binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by heyl itself. We selected most functions heyl had, and list some proteins which have the same functions with heyl. You can find most of the proteins on our site.

    Function Related Protein
    AF-1 domain binding HEYL
    RNA polymerase II core promoter sequence-specific DNA binding SOX8; ZNF335; SOX3; NLRC5; ZFPM1; IRF7; RBPJ; SUZ12; YAP1; SP1
    RNA polymerase II transcription corepressor activity CITED2; TLE1; HDAC1; CTBP1; HDGF; SIN3AA; SOX3; HEYL; TXLNB; NFIB
    microsatellite binding HEY2; HEY1; HEYL
    protein binding SPRY4; ZC3HAV1; DAG1; SND1; ADAM33; MAB21L2; ADCK5; KLRB1F; TYRP1; DLC1
    protein heterodimerization activity HIST1H2BO; KCNH5; VAPB; GABPB2; MCL1A; HIST1H4J; VEGFB; UGT1A9; AOC3; ATF4
    protein homodimerization activity BAXA; PEX11B; RABEP1; GDNF; FGFR2; AADAT; GNPTG; C1QB; PITX2; SLC39A13
    transcription corepressor activity JUNB; SIRT1; PSMC3; SFMBT1; CBX4; NCOR1; RARA; NR0B2; YAF2; RLIM
    transcription factor activity, RNA polymerase II core promoter sequence-specific PAX7; HEY1; MEF2C; SMAD3; TFAP2B; NKX3; HEY2; HEYL; MAX
    transcription factor activity, protein binding HEY2; HEY1; HEYL
    transcription factor activity, sequence-specific DNA binding TBX21; ZNF311; WT1A; FUBP1; NPAS1; NR2F6; NCOR1; SCML2; ONECUT3; ATF4B2
    transcription factor binding PARP1; YWHAZ; ATF7; GCM1; KDM1A; NIF3L1; APBB3; RBFOX2; HDAC2; FOSB
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ZIC3; ESR1; MYC; MITFB; PHOX2B; SIX1; TXK; EBF4; ELF1; MESP1

    heyl has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with heyl here. Most of them are supplied by our site. Hope this information will be useful for your research of heyl.


    Fukada, S; et al. Molecular Regulation of Muscle Stem Cells by 'Quiescence Genes'. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 131:1329-1332(2011).
    Chen, LH; Al-Awqati, Q; et al. Segmental expression of Notch and Hairy genes in nephrogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 288:F939-F952(2005).

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