HEYL
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Official Full Name
hairy/enhancer-of-split related with YRPW motif-like -
Overview
Heyl is a member of the Hairy/ Enhancer of split (E(spl))-related with YRPW motif (Hey) genes, which are a subfamily of mammalian (E(spl))-related basic helix-loop-helix (bHLH) genes that encode a carboxy-terminal KPYRPWG sequence3. The proteins are also -
Synonyms
HEYL;hairy/enhancer-of-split related with YRPW motif-like;hairy/enhancer-of-split related with YRPW motif-like protein;bHLHb33;hairy/enhancer of split related with YRPW motif 3;HEY3;HRT-3;hHRT3;hHeyL;HEY-like protein;hairy-related transcription
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HEYL-13757H | Recombinant Human HEYL, His-tagged | E.coli | Human | His | 1-328a.a. | |
| HEYL-4719H | Recombinant Human HEYL Protein, GST-tagged | Wheat Germ | Human | GST |
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| HEYL-7600M | Recombinant Mouse HEYL Protein | Mammalian Cells | Mouse | His |
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| HEYL-9634Z | Recombinant Zebrafish HEYL | Mammalian Cells | Zebrafish | His |
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| HEYL-5573HCL | Recombinant Human HEYL 293 Cell Lysate | HEK293 | Human | Non |
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| HEYL-3530HF | Recombinant Full Length Human HEYL Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 328 amino acids |
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| HEYL-4143M | Recombinant Mouse HEYL Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| HEYL-4143M-B | Recombinant Mouse HEYL Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HEYL involved in several pathways and played different roles in them. We selected most pathways HEYL participated on our site, such as Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants,Constitutive Signaling by NOTCH1 PEST Domain Mutants,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with HEYL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Diseases of signal transduction | OPN1MW2,CPSF6,CTBP2,RLBP1,JAG1,FGFR1OP,TRIM24,HEY1,LRRFIP1,JAG2 |
| Signal Transduction | CXCR7B,GPR37L1,ARHGAP1,MKL1,CRHR2,ARHGEF1B,PDK4,HCRT,PRLH,CCL19A.2 |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | HDAC5,HEY1,ADAM10,HDAC6,CCNC,HEY2,JAG1,MIB1,CDK8,JAG2 |
| NOTCH1 Intracellular Domain Regulates Transcription | HEY1,TLE2,TLE4,HEY2,TLE3,TLE1,TUBB3 |
| Disease | AP2S1,RLBP1,SYT2,NA,STX1B,CPSF6,OPN1LW,KREMEN2,OS9,CUX1 |
| Signaling by NOTCH | TLE4,RAB6A,MDKB,TLE3,TLE2,DTX2,MDKA,MDK,DNER,DLK1 |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | HDAC6,HEY2,JAG1,JAG2,CDK8,HEY1,HDAC5,CCNC,MIB1,ADAM10 |
| Signaling by NOTCH1 | DNER,DLK1,DTX2,TLE3 |
Protein Function
HEYL has several biochemical functions, for example, AF-1 domain binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HEYL itself. We selected most functions HEYL had, and list some proteins which have the same functions with HEYL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | CDX4,BARHL2,MESP1,ARID3B,KLF15,E2F4,GRHL1,PBX1,PAX8,SIX1 |
| transcription factor activity, RNA polymerase II core promoter sequence-specific | HEY1,MEF2C,NKX3,PAX7,SMAD3,MAX,TFAP2B,HEY2 |
| transcription factor binding | PRICKLE1,TBP,KCNA3,HHEX,ENPP2,NR0B2A,MDFIC,CSNK2B,GATA6,TRIB1 |
| transcription corepressor activity | HIF3A,TFAP2B,PPP1R13L,SAP30,SSX2,RLIM,CRYM,SUFU,KLF12,TGIF1 |
| protein homodimerization activity | IKZF2,TOP2A,HMGCL,RBM11,NTSR1,MGST1,Bcl2a1b,NKX2-5,ERP29,HES1 |
| RNA polymerase II transcription corepressor activity | SIN3A,CTBP1,SIN3B,TCERG1,URI1,HDAC1,UXT,TFAP2B,OLIG3,TLE1 |
| RNA polymerase II core promoter sequence-specific DNA binding | H2AFZ,HNF4A,TCF7L2,SMAD5,ZFPM1,H2AFY,STAT5A,SOX3,NR4A2,RUVBL2 |
| protein binding | RET,ASMTL,JMJD6,DCLRE1B,FBXO2,IFI16,CD163,RNF4,SEC22B,RAB35 |
| microsatellite binding | HEY2,HEY1 |
Interacting Protein
HEYL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HEYL here. Most of them are supplied by our site. Hope this information will be useful for your research of HEYL.
RBPMS;MDFI;RPGRIP1;SMAD7;SMAD9;SKIL;HTT;ATXN1;PPP1CA;SMAD3;LAPTM5;ATF7IP
Resources
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References
- Fukada, S; et al. Molecular Regulation of Muscle Stem Cells by 'Quiescence Genes'. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 131:1329-1332(2011).
- Chen, LH; Al-Awqati, Q; et al. Segmental expression of Notch and Hairy genes in nephrogenesis. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 288:F939-F952(2005).
