HHAT
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Official Full Name
hedgehog acyltransferase -
Overview
Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725). -
Synonyms
HHAT;hedgehog acyltransferase;protein-cysteine N-palmitoyltransferase HHAT;FLJ10724;GUP2;MART 2;MART2;rasp;sit;ski;Skn;2810432O22Rik;AI462858;FLJ34867;AC115917.1;HHAT_HUMAN;MART-2;Melanoma antigen recognized by T cells 2;Melanoma antigen recognized by T-cells 2;MGC11697;OTTMUSP00000033669;Protein cysteine N palmitoyltransferase HHAT;RGD1311746;SKI1;Skinny hedgehog protein 1;Skinny hedgehog protein;OTTHUMP00000034608;OTTHUMP00000034611
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HHAT-255H | Recombinant Human HHAT Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| HHAT-6488Z | Recombinant Zebrafish HHAT | Mammalian Cells | Zebrafish | His |
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| HHAT-7609M | Recombinant Mouse HHAT Protein | Mammalian Cells | Mouse | His |
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| Hhat-3389M | Recombinant Mouse Hhat Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| HHAT-4149M | Recombinant Mouse HHAT Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| HHAT-4149M-B | Recombinant Mouse HHAT Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis,Signal Transduction,Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Hedgehog | DISP2,NOTUM,EVC2,EFCAB7,IFT88,WDR35,SCUBE2,CDON,CDC73,TTC21B |
| Signal Transduction | HEBP1,WDR19,KAL1A,ANXA1A,CRABP2A,OR7D2,KAL1,OR56A1,DISP2,KREMEN2 |
| Hedgehog ligand biogenesis | DISP2,NOTUM1A,OS9,NOTUM,SCUBE2,GPC5A,DERL2 |
Protein Function
HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity,2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity,2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| N-succinyltransferase activity | MBOAT4,DGAT2L6,Acnat1,NAT14,MBOAT1,CML5,LPCAT3,MBOAT7,ACNAT2,CML2 |
| N-acetyltransferase activity | MBOAT4,NAT6,MBOAT7,CML2,CML5,SAT1B,NAT15,NAT10,MBOAT1,SAT1A.1 |
| N-palmitoyltransferase activity | Acnat1,ACNAT2,MBOAT1,LPCAT3,CML5,MBOAT4,MBOAT7,NAT14,CML2,DGAT2L6 |
| ergosterol O-acyltransferase activity | LPCAT3,DGAT2L6,NAT14,CML5,Acnat1,MBOAT1,MBOAT7,ACNAT2,CML2,MBOAT4 |
| transferase activity, transferring acyl groups | GM4952,DGAT1A,ZDHHC3A,CHATB,GGACT.2,PIGW,MEIS2,LRAT,ACNAT2,TGM2B |
| S-acetyltransferase activity | CML2,Acnat1,NAT14,ACNAT2,MBOAT4,CML5,MBOAT1,DGAT2L6,MBOAT7,LPCAT3 |
| C-acyltransferase activity | MBOAT4,MBOAT1,LPCAT3,ACNAT2,DGAT2L6,CML5,CML2,MBOAT7,Acnat1,NAT14 |
| O-succinyltransferase activity | Acnat1,MBOAT7,CML2,DGAT2L6,LPCAT3,MBOAT4,MBOAT1,NAT14,ACNAT2,CML5 |
| O-acyltransferase activity | LPCAT3,MBOAT7,NAT14,MBOAT1,Acnat1,MBOAT4,CML5,PLA2G15,DGAT1B,ACNAT2 |
Interacting Protein
HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.
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References
- Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).
