HHAT

  • Official Full Name

    hedgehog acyltransferase

  • Overview

    Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725).

  • Synonyms

    HHAT;hedgehog acyltransferase;protein-cysteine N-palmitoyltransferase HHAT;FLJ10724;GUP2;MART 2;MART2;rasp;sit;ski;Skn;2810432O22Rik;AI462858;FLJ34867;AC115917.1;HHAT_HUMAN;MART-2;Melanoma antigen recognized by T cells 2;Melanoma antigen recognized by T-cells 2;MGC11697;OTTMUSP00000033669;Protein cysteine N palmitoyltransferase HHAT;RGD1311746;SKI1;Skinny hedgehog protein 1;Skinny hedgehog protein;OTTHUMP00000034608;OTTHUMP00000034611
Cat.# Product name Source (Host) Species Tag Protein Length Price
HHAT-255H Recombinant Human HHAT Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
HHAT-6488Z Recombinant Zebrafish HHAT Mammalian Cells Zebrafish His
HHAT-7609M Recombinant Mouse HHAT Protein Mammalian Cells Mouse His
Hhat-3389M Recombinant Mouse Hhat Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
HHAT-4149M Recombinant Mouse HHAT Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
HHAT-4149M-B Recombinant Mouse HHAT Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis,Signal Transduction,Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hedgehog ligand biogenesis GPC5A,SCUBE2,DERL2,NOTUM,NOTUM1A,DISP2,OS9
    Signaling by Hedgehog IFT88,EVC,SCUBE2,WDR35,DZIP1,TULP3,BBS13,RPGRIP1L,EVC2,IFT172
    Signal Transduction OPHN1,KAL1A,IFT122,PPEF1,NMBA,MYO9B,MAPK6,DHRS9,ARHGEF25,GPR37B

    Protein Function

    HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity,2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity,2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.

    Function Related Protein
    3-hydroxybutyryl-CoA thiolase activity MBOAT7,ACNAT2,MBOAT4,LPCAT3,NAT14,CML2,Acnat1,CML5,DGAT2L6,MBOAT1
    transferase activity TAB3,OAS1B,STT3B,GMPPAB,MAP4K6,LPCAT3,NMT1B,ROCK2A,B3GNT2A,SETD1BA
    Ras palmitoyltransferase activity ZDHHC9,MBOAT4,MBOAT1,CML2,ACNAT2,NAT14,CML5,MBOAT7,DGAT2L6,LPCAT3
    L-2-aminoadipate N-acetyltransferase activity LPCAT3,MBOAT7,Acnat1,MBOAT4,MBOAT1,DGAT2L6,CML5,ACNAT2,CML2,NAT14
    ergosterol O-acyltransferase activity Acnat1,CML5,NAT14,CML2,DGAT2L6,ACNAT2,LPCAT3,MBOAT7,MBOAT1,MBOAT4
    protein-cysteine S-acyltransferase activity LPCAT3,MBOAT1,CML2,MBOAT7,CML5,Acnat1,MBOAT4,NAT14,DGAT2L6,ACNAT2
    lanosterol O-acyltransferase activity MBOAT7,DGAT2L6,CML5,ACNAT2,MBOAT1,NAT14,MBOAT4,Acnat1,LPCAT3,CML2
    2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity CML2,MBOAT7,DGAT2L6,MBOAT4,ACNAT2,MBOAT1,NAT14,CML5,LPCAT3,Acnat1
    GTP binding GNL2,GNA11B,RAB24,DNM1L,IRGQ2,ARL10,ERAS,RAB19,RIT2,EHD2

    Interacting Protein

    HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.

    Resources

    Research Area

    References

    • Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).

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