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Official Full Name major histocompatibility complex, class II, DO alpha
Background HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level.
Synonyms HLA-DOA; major histocompatibility complex, class II, DO alpha; HLA DNA, HLA DZA; HLA class II histocompatibility antigen, DO alpha chain; HLA D0 alpha; HLA class II histocompatibility antigen, DO alpha chain precursor; HLA DNA; HLA DZA; HLADZ; Lymphocyte antigen; Major histocompatibility complex, class II, DN alpha; MHC class II antigen DOA; MHC DN alpha; MHC DZ alpha; HLA-D0-alpha; MHC DN-alpha; HLA-DNA; HLA-DZA
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DOA-13814H Recombinant Human HLA-DOA, GST-tagged E.coli GST
    Human HLA-DOA-232H Recombinant Human major histocompatibility complex, class II, DO alpha, His-tagged E.coli His
    Human HLA-DOA-4838H Recombinant Human HLA-DOA Protein, GST-tagged Wheat Germ GST
    Human HLA-DOA-5502HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    hla-doa involved in several pathways and played different roles in them. We selected most pathways hla-doa participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-doa were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome SFTPA1; ATP6AP1B; ATP6V1E2; RAC1A; SEC22BB; HLA-DRA; TUBB1; BLA; H2-Q10; CD209A
    Cell adhesion molecules (CAMs) CD226; CLDNA; NEO1A; ICAM1; HLA-DRB4; CLDN17; ITGB7; HLA-A; H2-AA; CLDN19
    Antigen processing and presentation HLA-DQB1; NFYC; HSPA2; HLA-DRB4; RFX5; HLA-DMA; H2-Q10; TAP1; HSPA1A; IFI30
    Intestinal i BLA; IL4; ICOS; HLA-DQA2; IL15; TGFB1; H2-AA; HLA-DRB5; CXCR4A; HLA-DOA
    ne network for IgA production CXCL12; CD80; HLA-DOB; BLB2; HLA-DRB5; MHC2DAB; HLA-DRB4; IL5; CCL25B; CCR9A
    Type I diabetes mellitus ICA1; IL12A; H2-Q10; HLA-E; IFNG; Il2; HLA-DPB1; GAD1; CD28; HLA-F
    Leishmaniasis IL12B; CR1; IL12A; FCGR2C; FCGR1; TGFB2; STAT1; HLA-DPA1; TLR2; MYD88
    Toxoplasmosis PIK3R5; MAPK8; MAP3K7; IL10RB; PIK3CD; PIK3CB; HLA-DQA2; Toxoplasma Gondii Dense Granule Protein 7; HLA-DPB1; LAMB2
    Staphylococcus aureus infection cgr2b; DSG1; DSG1C; ITGAM; DSG1A; HLA-DQB1; FCGR4; SELPLG; HLA-DMA; ITGB2
    Tuberculosis CARD9; IL1B; HLA-DRB5; HLA-DRA; IFNA13; NFYC; PIK3C3; SPHK1; CALM2; TGFB3
    Influenza A HSPA1L; TNFSF10; PIK3R5; XPO1; MX1; BMA1; Fasl; IFNA21; IFNA8; IL12A
    HTLV-I infection TGFBR1; IL1R1; TGFBR2; KAT2A; MAP2K4; RAN; WNT16; DVL3; TLN1; MYB
    Herpes simplex infection IRF9; MCRS1; TLR2-1; SRSF1A; PTPN11; BLA; HCFC2; ABCB3L1; IFIT1; POU2F3
    Asthma IL9; CD40LG; IL3; IL4; TNF; CD40; PRG2; IL5; HLA-DOB; HLA-DQB1
    Autoi TSHR; H2-Q10; TPO; Il2; HLA-E; Fasl; HLA-DRB4; IFNA4; HLA-DQA2; HLA-DQA1
    ne thyroid disease TSHB; IFNA10; IFNA8; HLA-DMA; HLA-B; IFNA17; HLA-DQA1; CD86; HLA-DOA; IFNA2
    Inflammatory bowel disease (IBD) IL13; HLA-DOA; RELA; Il23a; HLA-DRB3; IL12A; MAF; TGFB2; TLR5; IL1B
    Systemic lupus erythematosus HIST1H3A; H2AFB1; HLA-DMA; HIST1H4G; Hc; SNRPD1; HIST1H4J; HIST1H2AD; C8A; FCGR1A
    Rheumatoid arthritis ATP6V0A2; Il23a; Il12b; IL1B; ATP6V1F; ATP6V1G1; ATP6V1C2; LTB; GM-CSF; ATP6V1G2; CCL3L1
    Allograft rejection HLA-B; HLA-DRB4; MICA; CD80; CD86; FASLG; HLA-DRB3; HLA-DQA1; H2-Q10; HLA-DMB
    Graft-versus-host disease HLA-DRB3; CD80; KIR2DL1; H2-AA; HLA-DOA; HLA-F; GZMB; HLA-DRB1; KIR2DL3; FASLG
    Viral myocarditis EIF4G2; HLA-DRB4; HLA-DPB1; SGCD; HLA-DOB; FYN; RAC2; ITGB2; ACTG1; CASP8

    hla-doa has several biochemical functions, for example, MHC class II protein complex binding, MHC class II receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-doa itself. We selected most functions hla-doa had, and list some proteins which have the same functions with hla-doa. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein complex binding HLA-DOA; PKM; HLA-DOB; HSPA8; CD74; HLA-DRA; YWHAE; ANXA11; MS4A1; HLA-DMA
    MHC class II receptor activity HLA-DRB4; HLA-DRA; HLA-DQB1; HLA-DRB1; HLA-DQA1; HLA-DOA; HLA-DOB; HLA-DPA1; HLA-DQA2; HLA-DQB2
    protein binding CEBPG; GDI2; IL1R1; ZNF317; DDB2; MAP4K2; ARMCX5-GPRASP2; MAPKAP1; C21orf119; DCLRE1B

    hla-doa has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-doa here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-doa.


    Yucesoy, B; Johnson, VJ; et al. Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 56:382-387(2014).
    Reynolds, RJ; Kelley, JM; et al. Genetic association of htSNPs across the major histocompatibility complex with rheumatoid arthritis in an African-American population. GENES AND IMMUNITY 11:94-97(2010).
    van Lith, M; van Ham, M; et al. Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies. IMMUNOGENETICS 54:591-595(2002).

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