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Official Full Name major histocompatibility complex, class II, DQ alpha 2
Background This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells.
Synonyms HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2; HLA DXA; HLA class II histocompatibility antigen, DQ alpha 2 chain; HLA-DQA1; DX alpha chain; MHC class II DQA2; HLA class II histocompatibility antigen, DQ(6) alpha chain; HLA-DXA; DX-ALPH
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DQA2-1279H Recombinant Human HLA-DQA2 Protein (24-214 aa), His-tagged E.coli His
    Human HLA-DQA2-5494HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    hla-dqa2 involved in several pathways and played different roles in them. We selected most pathways hla-dqa2 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-dqa2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome ITGB3; HLA-DQA2; TUBB2A; ITGB2; ACTB1; M6PR; TUBA8L3; TLR2-2; CD209C; ATP6V1G2
    Cell adhesion molecules (CAMs) SELP; ITGB2L; NCAM1A; SELPLG; NFASCA; H2-AA; ITGB1; HLA-DRA; JAM2; CD276
    Antigen processing and presentation HLA-DMA; HSPA4; HLA-DRA; KIR2DL4; HSPA1L; KIR3DL2; HSP90AB1; H2-AA; HLA-DPB1; PDIA3
    Intestinal i CCR9A; IL15RA; CXCL12A; PIGR; BLB2; HLA-DRB1; H2-AB1; HLA-DQA2; CXCR4A; MHC2DEB
    ne network for IgA production CCR9A; HLA-DPB1; BMA2; BMA1; H2-AA; ICOS; ITGA4; CXCR4; BLA; BLB2
    Type I diabetes mellitus Il2; PTPRN; Fasl; CD28; INS2; HLA-DMB; HLA-G; HLA-C; LTA; HLA-DPA1
    Leishmaniasis MAPK3; NFKBIA; HLA-DRB4; NOS2; HLA-DPA1; CR1; HLA-DQB1; IL12B; PTGS2; TAB2
    Toxoplasmosis H2-AB1; IL10RB; LDLR; LAMB3; HLA-DMA; NOS2; AKT1; TNFRSF1A; PIK3R1; TGFB3
    Staphylococcus aureus infection FCGR3; PTAFR; FCGR4; C5AR1; CFB; FCGR2C; HLA-DOB; MBL2; HLA-DRA; FCAR
    Influenza A IL-8; IFNA14; IL33; NLRX1; HLA-DQA1; IFN-a; ACTG1; HLA-DRB4; HLA-DQA2; EIF2AK3
    HTLV-I infection WNT3A; VDAC3; FZD5; CCNB2; CRTC2; FZD10; HLA-DQA2; LTBR; FZD2; VDAC1
    Herpes simplex infection SRSF6A; SRSF5; CCL2; TLR2-1; PTPN11; SRSF2B; HLA-B; H2-AA; NFKBIA; NXF1
    Epstein-Barr virus infection HSPA1B; NFKBIA; CD44; PIK3CB; ICAM1; YWHAB; PSMD11; PSMC3; LYN; AKT1
    Autoi IFNA8; Ifna15; HLA-DRA; TG; Fasl; TSHB; HLA-C; HLA-DPA1; FAS; IFNA13
    ne thyroid disease IFNA8; IL4; IFNA10; H2-Q10; TPO; HLA-E; HLA-DQA1; HLA-DMB; Il2; IFNA12
    Inflammatory bowel disease (IBD) GATA3; IL4R; HLA-DQA1; HLA-DRB5; HLA-DMB; TLR5; TLR4; STAT1; IL23R; IL12RB2
    Systemic lupus erythematosus HIST1H2AN; C2; HIST1H2AO; C1RA; HIST1H4G; Hc; HIST1H2AJ; HIST1H4J; ELANE; TRIM21
    Rheumatoid arthritis HLA-DRB5; ATP6AP1; IFNG; ATP6V1E1; ITGAL; CCL5; CD80; ATP6V0A2; TNFSF11; TLR2
    Allograft rejection HLA-DPB1; HLA-DRA; HLA-F; HLA-DRB5; H2-AA; CD86; HLA-DMA; HLA-DMB; IL5; TNF
    Graft-versus-host disease HLA-DPB1; KLRD1; HLA-DQA1; KIR2DL3; HLA-G; Il2; KIR3DL1; HLA-DOB; HLA-DRA; CD28
    Viral myocarditis CXADR; HLA-DOB; MYH7; HLA-DRB5; HLA-DPA1; CCND1; HLA-C; HLA-DPB1; H2-Q10; ICAM1

    hla-dqa2 has several biochemical functions, for example, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-dqa2 itself. We selected most functions hla-dqa2 had, and list some proteins which have the same functions with hla-dqa2. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity HLA-DPA1; HLA-DQB2; HLA-DRB1; HLA-DQA2; HLA-DOB; HLA-DQA1; KRT17; HLA-DRB3; HLA-DRB4; HLA-DOA

    hla-dqa2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-dqa2 here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-dqa2.

    Yucesoy, B; Johnson, VJ; et al. Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 56:382-387(2014).

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