HLA-DQA2 Protein


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Official Full Name major histocompatibility complex, class II, DQ alpha 2
Background This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells.
Synonyms HLA-DQA2; major histocompatibility complex, class II, DQ alpha 2; HLA DXA; HLA class II histocompatibility antigen, DQ alpha 2 chain; HLA-DQA1; DX alpha chain; MHC class II DQA2; HLA class II histocompatibility antigen, DQ(6) alpha chain; HLA-DXA; DX-ALPH
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DQA2-1279H Recombinant Human HLA-DQA2 Protein (24-214 aa), His-tagged E.coli His
    Human HLA-DQA2-5494HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A

    HLA-DQA2 involved in several pathways and played different roles in them. We selected most pathways HLA-DQA2 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DQA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome C3A.2; Itgam&Itgb2; OLR1; RILP; CALR3B; ATP6V1H; TLR2-2; THBS2; DYNC1LI1; TUBB6
    Cell adhesion molecules (CAMs) CD22; HLA-DRB1; NADL1.2; CLDN15; CLDN22; NRXN1; H2-AB1; HLA-DPB1; ITGA9; CNTN1
    Antigen processing and presentation HSPA1L; KIR3DL1; CTSB; HLA-F; HLA-DMA; HSPA4; HLA-DRB5; CD74; HSPA6; NFYC
    Intestinal i CD40; IL6; HLA-DRB3; HLA-DQB1; MHC2DAB; CXCR4; H2-AA; PIGR; BLB2; Icosl
    ne network for IgA production CD40; AICDA; ICOSLG; CCL27B; CD80; CD86; HLA-DRB5; HLA-DPA1; HLA-DQA2; MHC2DEB
    Type I diabetes mellitus INS; HLA-DOB; HLA-B; IL12A; HLA-DRB4; HLA-E; HLA-C; HSPD1; IL1A; HLA-G
    Leishmaniasis MYD88; TGFB3; IFNGR2; FCGR1; HLA-DMA; MARCKSL1; FCGR2A; HLA-DQA2; CR1; PTGS2
    Toxoplasmosis LAMC1; LAMA4; ALOX5; BIRC2; PIK3R1; TAB2; IFNG; HLA-DRB4; LAMA3; HLA-DOB
    Staphylococcus aureus infection PTAFR; FCAR; FPR3; C5; ITGAL; FCGR2C; HLA-DMA; FCGR4; HLA-DMB; ICAM1
    Tuberculosis HLA-DOB; RHOA; CAMK2D; KSR1; IL12A; ITGAM; TGFB1; CARD9; PPP3R2; SPHK1
    Influenza A NFKBIA; BLB2; IFN-a; IFNA21; RAF1; PLG; SLC25A6; TRIM25; MAPK10; Ccl12
    HTLV-I infection SPI1; CRTC1; KRAS; TGFB2; GPS2; MYB; SLC25A31; HLA-DOB; HLA-C; AKT2
    Herpes simplex infection CUL1A; TLR9; TRP53; IFNPHI1; C3; IFNA3; PPP1CAA; CDK1; PPP1CB; NFKB1
    Epstein-Barr virus infection FGR; PSMD1; SND1; TRAF6; POLR2H; VIM; DDX58; AKT2; NFKB2; TYK2
    Autoi HLA-G; Il2; HLA-DPA1; FAS; HLA-DMA; H2-Q10; H2-AA; HLA-DMB; CD40; IFNA1
    ne thyroid disease IFNA6; IFNA4; IFNA12; HLA-DRB3; IFNA5; HLA-DQA1; CD80; TSHB; Ifna15; IFNA16
    Inflammatory bowel disease (IBD) IL1B; TGFB2; TGFB1; IL13; IL6; IL17A; RORA; TLR5; NFKB1; H2-AA
    Systemic lupus erythematosus HIST1H2AG; H2AFV; HIST1H4H; HIST1H2AM; HIST2H3C2; HIST1H2AN; HLA-DQB1; HIST2H3A; HIST1H2BP; CD80
    Rheumatoid arthritis ATP6AP1; LTB; HLA-DQA1; HLA-DRB5; ATP6V1H; ATP6V1F; ATP6V1G1; Il23a; Il12b; IL1A; TNFSF11
    Allograft rejection HLA-E; HLA-DOA; H2-AB1; HLA-DQA2; CD28; HLA-G; HLA-DRB3; HLA-DOB; IL12B; HLA-B
    Graft-versus-host disease IL1A; CD80; HLA-DOA; HLA-DMB; Fasl; FASLG; KIR3DL1; H2-AB1; GZMB; PRF1
    Viral myocarditis EIF4G2; PRF1; HLA-DRB5; HLA-A; Casp3; SGCG; ITGB2L; ACTG1; HLA-DQA2; ABL1

    HLA-DQA2 has several biochemical functions, for example, MHC class II receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DQA2 itself. We selected most functions HLA-DQA2 had, and list some proteins which have the same functions with HLA-DQA2. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II receptor activity HLA-DRB3; HLA-DQA1; HLA-DOA; HLA-DRB1; HLA-DOB; HLA-DQB2; HLA-DRB4; HLA-DPA1; HLA-DQB1; KRT17

    HLA-DQA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DQA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DQA2.

    Yucesoy, B; Johnson, VJ; et al. Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 56:382-387(2014).

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