HLA-DRB5 Protein


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Official Full Name major histocompatibility complex, class II, DR beta 5
Background HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Synonyms HLA-DRB5; major histocompatibility complex, class II, DR beta 5; DR beta 5 chain; DR 9; DR beta 5; DR beta-5; DR beta5; DR2 beta 2; DR2-beta-2; DR9; DRB5_HUMAN; Dw2; FLJ76359; HLA class II histocompatibility antigen; HLA class II histocompatibility antigen DR beta 5 chain; HLA class II histocompatibility antigen DRB1-9 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA DRB; Human leucocyte antigen DRB5; Leukocyte antigen class II; Major histocompatibility complex, class II, DR beta 51; MHC class II antigen DRB1*9; MHC class II antigen DRB5; MHC class II HLA beta chain; MHC HLA-DR-beta cell surface glycoprotein; MHC HLA-DR-beta chain; DR-9; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DRB1-9 beta chain; HLA-DRB
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-DRB5-4304H Recombinant Human HLA-DRB5 protein, His-tagged E.coli His
    Human HLA-DRB5-104H Recombinant Human HLA-DRB5, His-tagged HEK293 His
    Human HLA-DRB5-5497HCL Recombinant Human HLA 293 Cell Lysate HEK293 N/A
    Human HLA-DRB5-799HCL Recombinant Human HLA-DRB5 cell lysate N/A

    HLA-DRB5 involved in several pathways and played different roles in them. We selected most pathways HLA-DRB5 participated on our site, such as Phagosome, Cell adhesion molecules (CAMs), Antigen processing and presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-DRB5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome RAC1A; LAMP2; Itgam&Itgb2; BMA2; CLEC4M; ATP6V0A4; RAB7A; ITGB3B; FCGR3A; HLA-G
    Cell adhesion molecules (CAMs) MPZL1; ITGB1; CD8A; L1CAM; CD58; CLDN11B; NRXN3; MPZL1L; BF1; PVRL1B
    Antigen processing and presentation HSPA5; HSPA4; CD8B; HLA-F; CTSL1; HLA-DOB; HSPA1A; PSME2; KIR3DL2; HLA-DRB5
    Hematopoietic cell lineage CD1d1; CD1E, B2M; CD2; CD1E; DNTT; IL9R; HLA-DRB1; IL7R; CD19; HLA-DRB4
    Intestinal i HLA-DRA; CXCL12; CD40LG; CCR9A; PIGR; CCR10; MHC2A; IL4; HLA-DOA; Il2
    ne network for IgA production CXCR4B; HLA-DRB4; H2-AA; BLA; Icosl; CD40; HLA-DPB1; TNFSF13; HLA-DPA1; HLA-DQA2
    Type I diabetes mellitus FAS; HSPD1; HLA-A; INS; FASLG; H2-Q10; PTPRN2; TNF; Il2; PTPRN
    Leishmaniasis CYBA; H2-AB1; HLA-DRA; FCGR3A; NCF2; TNF; IRAK4; FCGR3; PTGS2; MAPK1
    Toxoplasmosis TGFB3; MYD88; IKBKB; Toxoplasma Gondii Profilin Family Protein; XIAP; BIRC2; IL10RA; LAMA3; HSPA1L; LAMB4
    Staphylococcus aureus infection PLG; Itgam&Itgb2; cgr2b; FPR1; HLA-DRB4; HLA-DOB; CFI; FCAR; ITGB2; C1QA
    Tuberculosis FCGR2A; Itgam&Itgb2; IFNA13; Il23a; Il12b; IL6; FADD; RFX5; IFNA4; PPP3R2; CALM1
    HTLV-I infection PIK3R1; RANBP1; SMAD3; TNF; Fzd4; PDGFB; HLA-F; TBPL2; CDC27; WNT16
    Herpes simplex infection IFNAR1; MHC2DCB; TRAF2; IL1B; TAF13; CSNK2A2A; IL12B; CASP3A; SFRS9; HLA-G
    Epstein-Barr virus infection NFKBIA; ITGAL; TRAF3; HSPA1L; RBPJL; POLR2F; CSNK2B; MAPK12; NEDD4; HLA-DPA1
    Asthma IL13; MS4A2; HLA-DPB1; EPX; HLA-DOB; IL4; HLA-DQA1; IL9; CD40LG; TNF
    Autoi Ifna15; IFNA5; IFNA12; Il2; HLA-DRB3; IFNA6; Ifna11; FASLG; H2-AA; HLA-DRB5
    ne thyroid disease HLA-DQA1; HLA-C; Fasl; HLA-F; HLA-DRB1; IFNA21; IL5; IFNA2; HLA-DRA; GZMB
    Inflammatory bowel disease (IBD) IL4; HLA-DQA2; IL22; FOXP3; HLA-DOA; HLA-DPA1; IL5; HLA-DRB5; IL6; H2-AA
    Systemic lupus erythematosus HIST1H2AI; HLA-DPA1; SNRPB; H2AFX; SSB; HIST1H3G; H2AFZ; HIST2H3C1; C2; HIST2H4A
    Rheumatoid arthritis HLA-DQB1; IFNG; ATP6V0A1; ATP6V1G1; TGFB1; IL17A; ITGB2; HLA-DRA; Ccl12; H2-AB1
    Allograft rejection CD86; Il2; IL12B; HLA-DPB1; HLA-DRB1; HLA-DRA; TNF; PRF1; Fasl; IFNG
    Graft-versus-host disease HLA-DPA1; KIR2DL3; FAS; HLA-DOA; PRF1; FASLG; CD80; H2-AA; H2-Q10; IL1B
    Viral myocarditis HLA-DRB1; HLA-DQB1; CD86; FYN; CD80; SGCA; H2-AB1; HLA-B; RAC2; HLA-DOB

    HLA-DRB5 has several biochemical functions, for example, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-DRB5 itself. We selected most functions HLA-DRB5 had, and list some proteins which have the same functions with HLA-DRB5. You can find most of the proteins on our site.

    Function Related Protein
    peptide antigen binding MHC1UEA; MHC1UBA; MHC1UFA; HLA-DRB5; MHC1ZFA; MHC1ZHA; H2-Q10; MAML1; TUBB3; HLA-B

    HLA-DRB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-DRB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-DRB5.

    yscP; tolC; mglA3; q81sn0_bacan; q81t03_bacan; q8clt0_yerpe

    Yucesoy, B; Talzhanov, Y; et al. Genetic variants within the MHC region are associated with immune responsiveness to childhood vaccinations. VACCINE 31:5381-5391(2013).
    Louthrenoo, W; Kasitanon, N; et al. Association of HLA-DRB1*15:02 and DRB5*01:02 allele with the susceptibility to systemic sclerosis in Thai patients. RHEUMATOLOGY INTERNATIONAL 33:2069-2077(2013).

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