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Official Full Name homer homolog 3 (Drosophila)
Background This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.
Synonyms HOMER3; homer homolog 3 (Drosophila); homer protein homolog 3; HOMER 3; HOME3_HUMAN; Homer 3D protein; Homer neuronal immediate early gene 3; Homer-3; VESL3; Homer, neuronal immediate early gene, 3
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HOMER3-1115H Recombinant Human HOMER3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HOMER3-13881H Recombinant Human HOMER3, His-tagged E.coli His
    Human HOMER3-247H Recombinant Human HOMER3 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human HOMER3-2568H Recombinant Human HOMER3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human HOMER3-4926H Recombinant Human HOMER3 Protein, GST-tagged Wheat Germ GST
    Human HOMER3-5436HCL Recombinant Human HOMER3 293 Cell Lysate HEK293 N/A
    Human HOMER3-67H Recombinant Human Homer Homolog 3 (Drosophila), His-tagged E.coli His
    Mouse Homer3-3427M Recombinant Mouse Homer3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse HOMER3-7777M Recombinant Mouse HOMER3 Protein Mammalian Cell His
    Rat HOMER3-2889R Recombinant Rat HOMER3 Protein Mammalian Cell His
    Rhesus Macaque HOMER3-2130R Recombinant Rhesus monkey HOMER3 Protein, His-tagged Mammalian Cell His
    Zebrafish HOMER3-11335Z Recombinant Zebrafish HOMER3 Mammalian Cell His

    HOMER3 involved in several pathways and played different roles in them. We selected most pathways HOMER3 participated on our site, such as FoxO signaling pathway, Glutamatergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with HOMER3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway IGF1RB; FOXO1A; PIK3R3B; SGK2A; IKBKB; NLK1; CAT; HOMER2; PIK3CG; TGFBR2
    Glutamatergic synapse GNG13; GRIA3; PRKACA; GNAO1; PLCB2; ADRBK2; SHANK2; SLC38A1; GNG11; GNGT1

    HOMER3 has several biochemical functions, for example, G-protein coupled glutamate receptor binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HOMER3 itself. We selected most functions HOMER3 had, and list some proteins which have the same functions with HOMER3. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled glutamate receptor binding HOMER3; HOMER1; HOMER1B; HOMER2
    protein C-terminus binding RABAC1; KSR1; TAX1BP3; MAPRE1; ATXN2; HSPG2; KCNK3; ATP1B1; PEX10; PPP1R9B
    protein binding RAB26; ARRB2; GNGT1; PACS1; LRP4; FAM46C; ODF2; EPM2A; ATP1B1; RMND1
    protein domain specific binding ATN1; HIST1H4L; STRN4; HIST4H4; HIST1H4N; TWIST2; MITD1; NFE2L2; STXBP1; TH

    HOMER3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HOMER3 here. Most of them are supplied by our site. Hope this information will be useful for your research of HOMER3.

    FAT1; Snw1; APP; ABI3; q9wmx2-pro_0000037548; SRPK2; Cdc16; FRYL; MOS; ul34_ebvb9; gp350_ebvb9; GN

    Mizutani, A; Kuroda, Y; et al. Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. JOURNAL OF NEUROSCIENCE 28:5369-5382(2008).

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