hsd11b2

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hsd11b2

Official Full Name hydroxysteroid (11-beta) dehydrogenase 2
Background There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
Synonyms HSD11B2; hydroxysteroid (11-beta) dehydrogenase 2; corticosteroid 11-beta-dehydrogenase isozyme 2; SDR9C3; short chain dehydrogenase/reductase family 9C; member 3; Corticosteroid 11 beta dehydrogenase isozyme 2; 11 beta HSD2; 11 beta hydroxysteroid dehydrogenase type 2; 11 DH2; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-DH2; AME; AME1; DHI2_HUMAN; HSD11K; HSD2; Hydroxysteroid 11 beta dehydrogenase 2; Hydroxysteroid 11 beta dehydrogenase isoenzyme 2; NAD dependent 11 beta hydroxysteroid dehydrogenase; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; Short chain dehydrogenase/reductase family 9C, member 3; OTTHUMP00000174801; short chain dehydrogenase/reductase family 9C member 3
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HSD11B2-1416H Recombinant Human HSD11B2 Protein (1-405 aa), His-tagged Yeast His
    Human HSD11B2-13951H Recombinant Human HSD11B2 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human HSD11B2-13952H Recombinant Human HSD11B2, GST-tagged E.coli GST
    Human HSD11B2-13953H Recombinant Human HSD11B2, GST-tagged Wheat Germ GST
    Human HSD11B2-27734TH Recombinant Human HSD11B2 Wheat Germ N/A
    Human HSD11B2-5378HCL Recombinant Human HSD11B2 293 Cell Lysate HEK293 N/A
    Mouse HSD11B2-7870M Recombinant Mouse HSD11B2 Protein Mammalian Cell His
    Rat Hsd11b2-20R Recombinant Rat Hsd11b2 protein, His-tagged E.coli His
    Rat HSD11B2-2921R Recombinant Rat HSD11B2 Protein Mammalian Cell His
    Zebrafish HSD11B2-11992Z Recombinant Zebrafish HSD11B2 Mammalian Cell His

    hsd11b2 involved in several pathways and played different roles in them. We selected most pathways hsd11b2 participated on our site, such as Steroid hormone biosynthesis, Aldosterone-regulated sodium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with hsd11b2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Steroid hormone biosynthesis COMTB; HSD17B12A; CYP3A25; PPP1R2; CYP2C55; UGT2A3; CYP2C54; UGT1A6A; H2-KE6; CYP2D26
    Aldosterone-regulated sodium reabsorption IRS1; INS1; PIK3CG; PRKCB; SLC9A3R2; MAPK1; MAPK3; PIK3R3; ATP1B2; ATP1A1

    hsd11b2 has several biochemical functions, for example, 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity, NAD binding, steroid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hsd11b2 itself. We selected most functions hsd11b2 had, and list some proteins which have the same functions with hsd11b2. You can find most of the proteins on our site.

    Function Related Protein
    11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity HSD11B1; HSD11B2
    NAD binding CYB5R3; HIBADHB; NDUFS2; UGDH; PARP1; GRHPRA; PHGDH; CTBP1; GPD1A; HIBADHA
    steroid binding ESR1; ESRRGA; ESR2A; HSD3B4; Ar; PAQR5B; CYP21A2; NR3C2; CYP3A4; HSD11B2

    hsd11b2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hsd11b2 here. Most of them are supplied by our site. Hope this information will be useful for your research of hsd11b2.

    Seltzer, J; Ashton, CE; et al. Gene and protein expression in pituitary corticotroph adenomas: a systematic review of the literature. NEUROSURGICAL FOCUS 38:-(2015).
    Appleton, AA; Lester, BM; et al. Examining the joint contribution of placental NR3C1 and HSD11B2 methylation for infant neurobehavior. PSYCHONEUROENDOCRINOLOGY 52:32-42(2015).

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