ift122 Protein, intraflagellar transport 122 homolog (Chlamydomonas)


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Official Full Name intraflagellar transport 122 homolog (Chlamydomonas)
Background This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms IFT122; intraflagellar transport 122 homolog (Chlamydomonas); WD repeat domain 10 , WDR10; intraflagellar transport protein 122 homolog; SPG; WDR10p; WDR140; CED; WD repeat domain 10; WDR10; WD repeat-containing protein 10; WD repeat-containing protein 140
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IFT122-14088H Recombinant Human IFT122, His-tagged E.coli His
    Human IFT122-5276HCL Recombinant Human IFT122 293 Cell Lysate HEK293 N/A
    Mouse IFT122-8047M Recombinant Mouse IFT122 Protein Mammalian Cell His
    Zebrafish IFT122-12147Z Recombinant Zebrafish IFT122 Mammalian Cell His

    ift122 involved in several pathways and played different roles in them. We selected most pathways ift122 participated on our site, such as Assembly of the primary cilium, Hedgehog off state, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with ift122 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of the primary cilium LZTFL1; SCLT1; PKD2; WDR35; TCTEX1D1; CEP89; DYNC1I2; RABL5; TSGA14; C11orf60
    Hedgehog off state IFT172; KIF3A; INTU; KIF7; WDR35; OFD1; IFT52; IFT88; TULP3; MKS1
    Intraflagellar transport IFT20; TRIP11; KIFAP3A; IFT172; KIFAP3B; TTC30B; KIFAP3; KIF3C; KIF17; WDR19
    Organelle biogenesis and maintenance MRPL37; UNC119B; C11orf60; TMEM216; MTFMT; TFB1M; BBS5; MRPL40; MRPL39; MRPL51
    Signal Transduction GRAP; CCNT2A; MKS1; NMT1B; FGD2; NOTUM; AMOTL2; CRABP1B; ABR; RBP4
    Signaling by Hedgehog BOC; TTC21B; CDON; WDR19; SCUBE2; EVC; GPR161; TULP3; CDC73; GAS8

    ift122 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ift122 itself. We selected most functions ift122 had, and list some proteins which have the same functions with ift122. You can find most of the proteins on our site.

    Function Related Protein
    protein binding PIK3R3; USP33; SMCO3; TF; CDPF1; CDCA8; RAC1; SIK3; CTSH; PRKD2

    ift122 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ift122 here. Most of them are supplied by our site. Hope this information will be useful for your research of ift122.

    ORF; b4dyc6_human; NUDCD3; NUDC; gatA

    Behal, RH; Miller, MS; et al. Subunit Interactions and Organization of the Chlamydomonas reinhardtii Intraflagellar Transport Complex A Proteins. JOURNAL OF BIOLOGICAL CHEMISTRY 287:11689-11703(2012).

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