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IFT88

  • Official Full Name

    intraflagellar transport 88 homolog (Chlamydomonas)

  • Overview

    This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms

    IFT88; intraflagellar transport 88 homolog (Chlamydomonas); tetratricopeptide repeat domain 10 , TTC10; intraflagellar transport protein 88 homolog; D13S1056E; hTg737; MGC26259; polaris homolog; Tg737; TPR repeat protein 10; tetratricopeptide repeat domai;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IFT88-14096H Recombinant Human IFT88, GST-tagged E.coli GST C-term-302a.a.
Human IFT88-5271HCL Recombinant Human IFT88 293 Cell Lysate HEK293 N/A
Human IFT88-5270HCL Recombinant Human IFT88 293 Cell Lysate HEK293 N/A
Zebrafish IFT88-222Z Recombinant Zebrafish IFT88 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

IFT88 involved in several pathways and played different roles in them. We selected most pathways IFT88 participated on our site, such as Assembly of the primary cilium, Endochondral Ossification, Hedgehog off state, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFT88 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Assembly of the primary ciliumEXOC6;CCP110;CEP70;FLR;CKAP5;CSNK1E;CCT4;C11orf60;DYNLL2
Endochondral OssificationCST5;SOX9A;NKX3.2;KIF3A;NKX3-2;SOX5;PTH;COL2A1;SERPINH1
Hedgehog off stateTTC21B;KIF7;GPR161;WDR19;IFT52;BBS13;IFT122;IFT172;INTU
Hedgehog signaling events mediated by Gli proteinsIFT88;SIN3B;CSNK1G2;SPOP;SAP18;KIF3A;CSNK1G3;MTSS1;SAP30
Intraflagellar transportTTC30B;IFT122;WDR34;OST4;KIF3C;TRAF3IP1;TCTEX1D1;KIF17;DYNLL2
Organelle biogenesis and maintenanceUNC119.1;C11orf60;MRPS27;BBS5;BBS9;EXOC5;GFM2;CHCHD1;KIFAP3B
Signal TransductionOXGR1A.2;GPRC6A;WNT8-2;RHOU;EDNRAB;FAM105B;PTPRK;AMOTL2B;GPR18
Signaling by HedgehogIFT52;BOC;SCUBE2;KIF7;CDON;BBS13;INTU;GPR161;RPGRIP1L

IFT88 has several biochemical functions, for example, kinesin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFT88 itself. We selected most functions IFT88 had, and list some proteins which have the same functions with IFT88. You can find most of the proteins on our site.

Function Related Protein
kinesin bindingTOR1A;SYBU;IFT88;KIF1B;KTN1;SNCA;KLC2;PLEKHM2;KIFAP3A
protein bindingMDM2;JAG1;TBC1D15;CCDC47;RTN4RL1B;MCM2;KIAA0368;BAG4;NDOR1

IFT88 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFT88 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFT88.

SMNDC1; PRRC2A; q99ib8-pro_0000045602

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