IFT88

  • Official Full Name

    intraflagellar transport 88 homolog (Chlamydomonas)
  • Overview

    This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene.
  • Synonyms

    IFT88;intraflagellar transport 88 homolog (Chlamydomonas);tetratricopeptide repeat domain 10 , TTC10;intraflagellar transport protein 88 homolog;D13S1056E;hTg737;MGC26259;polaris homolog;Tg737;TPR repeat protein 10;tetratricopeptide repeat domai
Cat.# Product name Source (Host) Species Tag Protein Length Price
IFT88-14096H Recombinant Human IFT88, GST-tagged E.coli Human GST C-term-302a.a.
IFT88-222Z Recombinant Zebrafish IFT88 Mammalian Cells Zebrafish His
IFT88-5270HCL Recombinant Human IFT88 293 Cell Lysate HEK293 Human Non
IFT88-5271HCL Recombinant Human IFT88 293 Cell Lysate HEK293 Human Non

    Involved Pathway

    IFT88 involved in several pathways and played different roles in them. We selected most pathways IFT88 participated on our site, such as Assembly of the primary cilium,Endochondral Ossification,Hedgehog off state, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFT88 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by Hedgehog KIF7,SPOPL,SPOP,NOTUM1A,IFT52,DISP2,BBS13,NOTUM,GAS8,EVC2
    Endochondral Ossification CST5,SOX5,ADAMTS4,CTSL2,MMP13,KIF3A,PTH,COL2A1,SOX6,FRZB
    Hedgehog signaling events mediated by Gli proteins KIF3A,SAP30,SAP18,SIN3B,LGALS3,CSNK1G3,CSNK1G2,SPOP,MTSS1
    Intraflagellar transport FLR,IFT20,DYNLL2B,DYNLL2A,KIFAP3,KIFAP3B,WDR35,IFT81,IFT172,TTC26
    Signal Transduction NPHP4,ARHGAP17B,RBP1,RHOU,CSHL1,CSNK1G2,ARHGEF1B,KREMEN1,IQGAP3,ADM2
    Hedgehog off state IFT172,OFD1,RPGRIP1L,MKS1,KIF3A,WDR35,IFT122,GPR161,TTC21B,BBS13
    Assembly of the primary cilium CCT5,NEK2,TTC30B,TSGA14,IFT46,DYF-1,CENPJ,ARF4A,IFT52,CCT3
    Organelle biogenesis and maintenance RAB3IP,DYNLRB2,IFT-20,TTC30A1,MRPS33,MRPS22,CHCHD1,TCTN1,IFT43,MRPL40

    Protein Function

    IFT88 has several biochemical functions, for example, kinesin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFT88 itself. We selected most functions IFT88 had, and list some proteins which have the same functions with IFT88. You can find most of the proteins on our site.

    Function Related Protein
    kinesin binding SNCA,KIF18B,KTN1,CD36,ARPC2,AP1AR,SYBU,KLC2,KIAA1279,SPAG9
    protein binding SMARCC1,PSMF1,NPBWR2,CEP290,ZNF238,TTC30B,PDE9A,NELL2,STX12,TES

    Interacting Protein

    IFT88 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFT88 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFT88.

    SMNDC1;PRRC2A;q99ib8-pro_0000045602

    Resources

    References

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