IFT88
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Official Full Name
intraflagellar transport 88 homolog (Chlamydomonas) -
Overview
This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. -
Synonyms
IFT88;intraflagellar transport 88 homolog (Chlamydomonas);tetratricopeptide repeat domain 10 , TTC10;intraflagellar transport protein 88 homolog;D13S1056E;hTg737;MGC26259;polaris homolog;Tg737;TPR repeat protein 10;tetratricopeptide repeat domai
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IFT88-14096H | Recombinant Human IFT88, GST-tagged | E.coli | Human | GST | C-term-302a.a. | |
| IFT88-222Z | Recombinant Zebrafish IFT88 | Mammalian Cells | Zebrafish | His |
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| IFT88-5270HCL | Recombinant Human IFT88 293 Cell Lysate | HEK293 | Human | Non |
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| IFT88-5271HCL | Recombinant Human IFT88 293 Cell Lysate | HEK293 | Human | Non |
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Involved Pathway
IFT88 involved in several pathways and played different roles in them. We selected most pathways IFT88 participated on our site, such as Assembly of the primary cilium,Endochondral Ossification,Hedgehog off state, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFT88 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Intraflagellar transport | IFT74,DYNLL2B,DYNLL2,C11orf60,DYNLL2A,KIFAP3,IFT-20,DYNLRB2,IFT52,KIF3B |
| Hedgehog signaling events mediated by Gli proteins | CSNK1G3,KIF3A,SIN3B,SAP18,SAP30,CSNK1G2,MTSS1,SPOP,LGALS3 |
| Hedgehog off state | IFT122,OFD1,GPR161,WDR35,BBS13,RPGRIP1L,INTU,TTC21B,WDR19,KIF3A |
| Endochondral Ossification | COL10A1,SOX5,FRZB,NKX3.2,RUNX2A,PTHLHA,PTHLH,CTSL2,ADAMTS5,COL2A1 |
| Signaling by Hedgehog | GPR161,TTC21B,IFT52,IFT172,IFT122,NOTUM1A,CDC73,HHAT,CDON,KIF7 |
| Organelle biogenesis and maintenance | KIF3CB,TTC26,MRPL28,IFT81,ATAT1,MRPL46,DYNLL2B,PKD1,MKS1,MRPS34 |
| Signal Transduction | PROKR1A,RLN3A,RAMP2,ADH8A,APOC2,ALDH8A1,RDH14,CLPS,ARHGEF18A,ANXA1A |
| Assembly of the primary cilium | UNC119.1,EXOC5,CCP110,CNGA5,AKAP9,TTC21B,CC2D2A,IFT172,CNGA2,CEP63 |
Protein Function
IFT88 has several biochemical functions, for example, kinesin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFT88 itself. We selected most functions IFT88 had, and list some proteins which have the same functions with IFT88. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| kinesin binding | GOLSYN,KIAA1279,JIP1,PRC1,KCNC1,NEK6,KIFAP3,KLC2,PLEKHM2,MAPK8IP3 |
| protein binding | BCL2L12,HNRPDL,IL32,USP46,HOXB6,GPR3,BRCC3,NTN1,HIST1H4C,PKD2L1 |
Interacting Protein
IFT88 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFT88 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFT88.
SMNDC1;PRRC2A;q99ib8-pro_0000045602
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