IGKC
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Official Full Name
immunoglobulin kappa constant -
Overview
Immunoglobulins belong to a group of related glyco proteins which make up 20% of serum proteins. Antigens and immunoglobulins react to confer immunity to individuals. Immunoglobulins have similar structures of two identical heavy chains and two identical light chains. Both the heavy chains and the light chains are divided into constant and variable regions. The constant regions have the same amino acid sequences between all the immunoglobulin classes. The variable regions have approximately 110 amino acids with high sequence variability. The amino acid sequence of the heavy chain determines the class of an immunoglobulin. The five types of immunoglobulin heavy chains are known as: IgG, IgA, IgM, IgD, and IgE. IgG is divided into four subclasses, and IgA is divided into two subclasses. In serum IgA and IgG are monomers with a single 4 polypeptide unit; while, IgM is a pen tamer. IgA may also form polymers. Kappa light chain antibody can be used for the identification of leukemias, plasmacytomas and certain non Hodgkin"s lymphomas. Kappa light chain contains one immunoglobulin like domain. The EU sequence has the INV allotypic marker, Ala 45 and Val 83. The ROY sequence has the INV allotypic marker, Ala 45 and Leu 83. -
Synonyms
immunoglobulin light chain;Human Kappa Protein;Kappa Protein;IGKC;immunoglobulin kappa constant
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| IGKC-844HCL | Recombinant Human IGKC cell lysate | Human | Non |
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| IGKC-11H | Recombinant Human IGKC protein, His-tagged | Mammalian Cells | Human | His | 2-107 aa |
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Involved Pathway
IGKC involved in several pathways and played different roles in them. We selected most pathways IGKC participated on our site, such as Adaptive Immune System,Antigen activates B Cell Receptor (BCR) leading to generation of second messengers,Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGKC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Classical antibody-mediated complement activation | C1rb,IgG3,IGKV1-5,CRP,IGLC2 |
| FCERI mediated MAPK activation | GRAP2B,GRAP2A,IGKV1-5,IGLC2,LCP2A |
| Antigen activates B Cell Receptor (BCR) leading to generation of second messengers | IGLC2,AKR1C1,ITPR2,BLK,IGKV1-5,PIK3AP1,SRMS,STIM1B,IGHM,AHCYL1 |
| Adaptive Immune System | CMTM2A,UBR1,AKT3,AP1M2,CTSL1,CD200,CTS7,UBE2V1,ITK,CTSO |
| Complement cascade | MASP2,BFB,FCN2,CFHL4,IgG3,IGLC2,GZMM,CRP,CFHL2,HBL3 |
| FCERI mediated Ca+2 mobilization | IGLC2,LCP2A,IGKV1-5,GRAP2A,GRAP2B,ITK |
| Creation of C4 and C2 activators | CRP,FCN1,IGLC2,MASP2,IgG3,FCN2,FCN3,HBL3,C1rb,IGKV1-5 |
| Binding and Uptake of Ligands by Scavenger Receptors | SAA1,NFX1,LOC479668,COL1A2,APOBB.1,IGKV1-5,COL1A1,Alb,HSPH1,HP |
Protein Function
IGKC has several biochemical functions, for example, antigen binding,immunoglobulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGKC itself. We selected most functions IGKC had, and list some proteins which have the same functions with IGKC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| antigen binding | LAG3,Ighg,LILRA2,IGHM,CD40,LILRB4,SLAMF1,IL7R,TSPAN4,HNRNPM |
| immunoglobulin receptor binding | CLEC4D,Ighg,FGR,FES,IGLC2,Ighg2b,IGLL1,IgG3,Ighg2a |
Interacting Protein
IGKC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGKC here. Most of them are supplied by our site. Hope this information will be useful for your research of IGKC.
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