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Official Full Name interleukin 10 receptor, alpha
Background The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Synonyms IL10RA; interleukin 10 receptor, alpha; CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1; interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Tag :
    • Fc
    • His
    • GST
    • Human IgG1 Fc
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL10RA-001H Recombinant Human IL10RA Protein Insect cell N/A
    Human IL10RA-002H Recombinant Human IL10RA Protein HEK293 N/A
    Mouse IL10RA-214M Recombinant Mouse IL10RA protein, Fc-tagged HEK293 Human IgG1 Fc
    Human IL10RA-1116H Recombinant Human IL10RA Protein (Met1-Asn235), His-tagged HEK293 His
    Mouse Il10ra-1234M Recombinant Mouse Il10ra Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus IL10RA-988R Recombinant Rhesus IL10RA Protein (Thr9-Asn245), His-tagged HEK293 His
    Human IL10RA-14141H Recombinant Human IL10RA, GST-tagged E.coli GST
    Human IL10RA-1648H Recombinant Human Interleukin 10 Receptor, Alpha Sf21 Insect Cell N/A
    Human IL10RA-211H Recombinant Human IL10RA, MIgG2a Fc-tagged CHO Fc
    Human IL10RA-212H Recombinant Human IL10RA, HIgG1 Fc-tagged CHO Fc
    Human IL10RA-236H Recombinant Human IL10RA protein HEK293 N/A
    Human IL10RA-29631TH Recombinant Human IL10RA N/A
    Human IL10RA-492H Recombinant Human Interleukin 10 Receptor, Alpha, Fc Chimera HEK293 Fc
    Human IL10RA-54H Recombinant Human IL10RA, His-tagged Insect Cell His
    Human IL10RA-9302H Recombinant Human IL10RA protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL10RA-9390H Recombinant Human IL10RA protein, His-tagged E.coli His
    Mouse Il10ra-1726M Recombinant Mouse Il10ra protein, His & GST-tagged E.coli His/GST
    Cynomolgus Monkey IL10RA-1185CCL Recombinant Cynomolgus IL10RA cell lysate Human Cell N/A
    Cynomolgus Monkey IL10RA-8837C Recombinant Cynomolgus IL10RA, Fc tagged Human Cell Fc/His
    Chicken IL10RA-3393C Recombinant Chicken IL10RA Mammalian Cell His
    Zebrafish IL10RA-4812Z Recombinant Zebrafish IL10RA Mammalian Cell His

    il10ra involved in several pathways and played different roles in them. We selected most pathways il10ra participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with il10ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL13; FLT3LG; IFNGR2; TNFRSF1A; GM2506; CXCL6; LTA; CSF2; PDGFB; RELT
    Epstein-Barr virus infection CSNK2B; HLA-DPA1; TP53; CD38; YWHAB; ICAM1; CCNA1; BCL2; PIK3R3; MAP3K14
    Jak-STAT signaling pathway SOCS3B; FHL1A; PIK3R2; IL-15RA; IFNAR1; TSLP; PTPN11A; CISH; PIK3CA; CTF1
    Toxoplasmosis BIRC3; LAMA1; H2-AA; LAMA2; GNAI1; LAMB1; LAMA4; PIK3R1; HSPA2; HSPA1L
    Tuberculosis Itgam&Itgb2; ATP6V0A4; IL1A; FCGR1A; IFNA7; IFNA16; HLA-DQA1; MAPK1; TLR1; CAMK2G

    il10ra has several biochemical functions, for example, interleukin-10 binding, interleukin-10 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by il10ra itself. We selected most functions il10ra had, and list some proteins which have the same functions with il10ra. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-10 binding IL10RA
    interleukin-10 receptor activity IL10RA
    protein binding ARNTL; CDC40; AP2S1; BAX; SPCS1; SSRP1; SF3B2; FRMPD4; HEMGN; IPO13
    receptor activity NR2C1; PVRL3B; NPC1; JMJD6; V1RA8; SLC20A2; VMN1R41; THRAP3; ITGB8; LYVE1
    signal transducer activity TMTOPS3A; APLNRA; OLFR15; FLNA; OR103-4; OPN4.1; MAPKAPK5; MAVS; OLFR477; S100A9

    il10ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il10ra here. Most of them are supplied by our site. Hope this information will be useful for your research of il10ra.

    NS; il10h_ebvb9; UL111A; IL10; q6f051_bacan; dnaE; ilvC2

    Matesanz-Isabel, J; Sintes, J; et al. New B-cell CD molecules. IMMUNOLOGY LETTERS 134:104-112(2011).
    Hennig, BJ; Fielding, K; et al. Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection. PLOS ONE 3:-(2008).


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