IL10RA
-
Official Full Name
interleukin 10 receptor, alpha
-
Background
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] -
Synonyms
IL10RA; interleukin 10 receptor, alpha; CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1; interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL10RA Related Articles
- IL10RA Related Gene Family
- IL10RA Related Research Area
- IL10RA Related Signal Pathway
IL10RA involved in several pathways and played different roles in them. We selected most pathways IL10RA participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL10RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCR9;CX3CR1;IL9R;LEPB;CCR1L1;TNFSF9;TNFRSF11B;BMPR1AA;CXCR4B |
| Epstein-Barr virus infection | TRADD;PIK3CG;POLR2C;PTMA;SPI1;HLA-F;GTF2E2;POLR2L;PIK3CB |
| Jak-STAT signaling pathway | SOCS3B;SOCS1;IL2RGB;MTOR;AOX2P;Il23a;IL22RA2;IL6ST;IL12A |
| Toxoplasmosis | PIK3CG;MAPK3;H2-AB1;ALOX5;IFNG;LAMC2;NFKB1;MAPK10;LAMA2 |
| Tuberculosis | BCL2;RFX5;FCGR1A;RAB7;RAF1;TRADD;CALM4;H2-AA;HSPA9 |
IL10RA has several biochemical functions, for example, interleukin-10 binding, interleukin-10 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL10RA itself. We selected most functions IL10RA had, and list some proteins which have the same functions with IL10RA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-10 binding | |
| interleukin-10 receptor activity | |
| protein binding | PABPC4;NSMAF;AGXT;MKI67IP;ITSN1;TFAP2A;ATP6V1G1;HIP1;EGR1 |
| receptor activity | ANTXR2A;NR2C2;GRIA3A;VMN1R49;OGFRL1;TLR1;SV2A;GABRA5;PVRL1A |
| signal transducer activity | PTGER1A;MAS1;GPR34L;ZDHHC17;OLFR510;TAS2R104;PTK2AA;LITAF;ZP3 |
IL10RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL10RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL10RA.
NS; il10h_ebvb9; UL111A; IL10; q6f051_bacan; dnaE; ilvC2
- Q&As
- Reviews
Q&As (10)
Ask a questionSurface plasmon resonance and isothermal titration calorimetry techniques quantify binding kinetics between IL10RA and IL-10, revealing affinity and association/dissociation rates.
Cutting-edge flow cytometry and single-cell transcriptomics uncover the expression patterns of IL10RA across diverse immune cell subsets.
NMR spectroscopy captures dynamic interactions, revealing the flexibility and movements of IL10RA and IL-10 during their binding events.
Surface proteomics and mass spectrometry identify proteins physically interacting with IL10RA, providing insights into its complex functional networks.
Proximity labeling and quantitative proteomics unveil dynamic changes in IL10RA-associated proteins, shedding light on response mechanisms.
X-ray crystallography and cryo-electron microscopy provide detailed structural insights into the changes in IL10RA's 3D arrangement upon binding to IL-10.
Site-directed mutagenesis and alanine scanning pinpoint key amino acids in IL10RA essential for IL-10 interaction, aiding in understanding binding determinants.
Genome-wide CRISPR screening identifies genes and pathways affecting IL10RA expression and function, aiding in understanding its regulatory network.
Co-immunoprecipitation and FRET techniques elucidate the assembly of multi-protein IL10RA-IL-10 receptor complexes in cellular environments.
CRISPR/Cas9-modified cell lines and gene knockout models help dissect intricate signaling pathways activated by IL10RA upon ligand engagement.
Customer Reviews (3)
Write a reviewGood for receptor binding studies. -
Consistent in bioactivity. -
Suitable for ELISA. -
Ask a Question for All IL10RA Products
Required fields are marked with *
My Review for All IL10RA Products
Required fields are marked with *