IL10RA

  • Official Full Name

    interleukin 10 receptor, alpha

  • Overview

    The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
  • Synonyms

    IL10RA; interleukin 10 receptor, alpha; CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1; interleukin-10 receptor subunit alpha; IL-10RA; IL-10R subunit 1; IL-10R subunit alpha; IL-10 receptor subunit alpha; interleukin-10 receptor subunit 1; interleukin-10 receptor alpha chain;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus
  • Rhesus monkey
  • Zebrafish
  • CHO
  • CHO cells
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Insect cell
  • Insect Cell
  • Mamanlian cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Yeast
  • C
  • Fc
  • His
  • Avi
  • Fc|His
  • Flag
  • GST
  • hFc
  • Myc
  • His|GST
  • Human IgG1 Fc
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL10RA-212H Active Recombinant Human IL10RA, HIgG1 Fc-tagged CHO Fc
Human IL10RA-236H Active Recombinant Human IL10RA protein HEK293 N/A
Human IL10RA-211H Active Recombinant Human IL10RA, MIgG2a Fc-tagged CHO Fc
Human IL10RA-051H Active Recombinant Human IL10RA protein, Fc/Avi-tagged, Biotinylated CHO cells Fc/Avi His22-Asn235
Human IL10RA-02H Active Recombinant human IL10RA Protein, Fc-tagged HEK293 Fc His 22 - Asn 235
Human IL10RA-29631TH Recombinant Human IL10RA N/A
Human IL10RA-9302H Recombinant Human IL10RA protein, MYC/DDK-tagged HEK293 Myc/DDK Predicted Molecular Mass: 150.4 (monomer) & 55.9 (truncated) kDa;SDS-PAGE: 210-225 kDa, reducing conditions.
Human IL10RA-14141H Recombinant Human IL10RA, GST-tagged E.coli GST 253-578a.a.
Human IL10RA-1648H Recombinant Human Interleukin 10 Receptor, Alpha Sf21 Insect Cell N/A
Human IL10RA-492H Recombinant Human Interleukin 10 Receptor, Alpha, Fc Chimera HEK293 Fc
Human IL10RA-54H Recombinant Human IL10RA, His-tagged Insect Cell His
Human IL10RA-9390H Recombinant Human IL10RA protein, His-tagged E.coli His Leu132~Asn235
Human IL10RA-1116H Active Recombinant Human IL10RA Protein (Met1-Asn235), His-tagged HEK293 His Met1-Asn235
Human IL10RA-5784HFL Recombinant Full Length Human IL10RA protein, Flag-tagged Mamanlian cells Flag
Human IL10RA-073H Recombinant Human IL10RA Protein, His-tagged E.coli His
Human IL10RA-4323H Recombinant Human IL10RA protein, His&Myc-tagged Yeast His&Myc 22-235aa
Human IL10RA-2993H Recombinant Human IL10RA Protein (Leu132-Asn235), His tagged E.coli His Leu132-Asn235
Human IL10RA-001H Active Recombinant Human IL10RA Protein Insect cell N/A
Human IL10RA-4296H Recombinant Human IL10RA Protein (His22-Asn235), C-Fc tagged Mammalian cells C-Fc His22-Asn235
Human IL10RA-4297H Recombinant Human IL10RA Protein (Met1-Asn235), C-His tagged Mammalian cells C-His Met1-Asn235
Human IL10RA-2859H Recombinant Human IL10RA protein(291-370 aa), C-His-tagged E.coli C-His 291-370 aa
Human IL10RA-002H Active Recombinant Human IL10RA Protein HEK293 N/A
Human IL10RA-2860H Recombinant Human IL10RA protein(31-230 aa), N-SUMO & C-His-tagged E.coli N-SUMO & C-His 31-230 aa
Human IL10RA-0297H Active Recombinant Human IL10RA protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi His22-Asn235
Mouse Il10ra-1726M Recombinant Mouse Il10ra protein, His & GST-tagged E.coli His/GST Leu17~Ile241
Mouse Il10ra-1658M Recombinant Mouse Il10ra Protein, His-tagged E.coli N-His Leu17-Ile241
Mouse Il10ra-1234M Recombinant Mouse Il10ra Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse IL10RA-214M Recombinant Mouse IL10RA protein, Fc-tagged HEK293 Human IgG1 Fc 460
Mouse IL10RA-56M Recombinant Mouse IL10RA protein, His/GST-tagged E.coli His/GST
Rhesus monkey IL10RA-220M Recombinant Rhesus monkey IL10RA protein, His-tagged HEK293 His His22-Asn235
Cynomolgus IL10RA-1307C Active Recombinant Cynomolgus IL10RA protein, Fc-tagged HEK293 Fc His22-Asn235
Cynomolgus Monkey IL10RA-8837C Recombinant Cynomolgus IL10RA, Fc tagged Human Cell Fc/His
Cynomolgus Monkey IL10RA-1185CCL Recombinant Cynomolgus IL10RA cell lysate Human Cell N/A
Rhesus IL10RA-981R Active Recombinant Rhesus IL10RA protein, hFc-tagged HEK293 hFc Thr9-Asn245
Rhesus IL10RA-988R Active Recombinant Rhesus IL10RA Protein (Thr9-Asn245), His-tagged HEK293 His Thr9-Asn245
Zebrafish IL10RA-4812Z Recombinant Zebrafish IL10RA Mammalian Cell His
Chicken IL10RA-3393C Recombinant Chicken IL10RA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IL10RA Related Signal Pathway

IL10RA involved in several pathways and played different roles in them. We selected most pathways IL10RA participated on our site, such as Cytokine-cytokine receptor interaction, Epstein-Barr virus infection, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL10RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFRSF10A;TGFB1A;CXCR6;IL17RA;PDGFRA;IL4;CCL27;VEGFC;IFNG1-2
Epstein-Barr virus infectionHLA-DPA1;PTMA;CD19;PSMD1;PIK3CD;AKT2;POLR2L;LYN;POLR3C
Jak-STAT signaling pathwayIFNA21;IL6ST;AOX3L1;IL4R;GRB2;PIK3CD;RNF207B;PIK3R2;GH2
ToxoplasmosisHSPA1B;Toxoplasma Gondii Profilin Family Protein;TGFB2;LAMA2;MAPK13;HLA-DRB3;GNAI1;IRGM;BIRC7
TuberculosisIL12A;FCER1G;RHOA;IFNA13;HLA-DRB1;Itgam&Itgb2;ATP6V0D1;MAPK12;IFNA7

IL10RA has several biochemical functions, for example, interleukin-10 binding, interleukin-10 receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL10RA itself. We selected most functions IL10RA had, and list some proteins which have the same functions with IL10RA. You can find most of the proteins on our site.

Function Related Protein
interleukin-10 binding
interleukin-10 receptor activity
protein bindingRASSF2;MAPK11;CNOT3;DPEP1;HPRT1;ZFP110;AIRE;ARNTL2;SLC7A1
receptor activityATRN;VMN1R44;AMHR2;GRIA3A;BTLA;ITGB3A;UNC13B;OGFRL2;VMN1R49
signal transducer activityPTGER1A;LPAR6;OLFR147;GNG2;PLCD1B;V2RH7;ADCYAP1R1A;OLFR497;EXORH

IL10RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL10RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL10RA.

NS; il10h_ebvb9; UL111A; IL10; q6f051_bacan; dnaE; ilvC2

Gene Family

IL

Research Area

Related articles

Matesanz-Isabel, J; Sintes, J; et al. New B-cell CD molecules. IMMUNOLOGY LETTERS 134:104-112(2011).
Hennig, BJ; Fielding, K; et al. Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection. PLOS ONE 3:-(2008).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How are innovative experimental techniques like surface plasmon resonance and isothermal titration calorimetry utilized to study the binding kinetics between IL-10RA and its ligand IL-10? 09/23/2022

Surface plasmon resonance and isothermal titration calorimetry techniques quantify binding kinetics between IL10RA and IL-10, revealing affinity and association/dissociation rates.

How are cutting-edge flow cytometry and single-cell transcriptomics techniques applied to dissect the heterogeneity in IL10RA expression across different immune cell subsets? 12/28/2021

Cutting-edge flow cytometry and single-cell transcriptomics uncover the expression patterns of IL10RA across diverse immune cell subsets.

How do researchers employ biophysical techniques like nuclear magnetic resonance (NMR) spectroscopy to unravel the dynamic interactions between IL10RA and IL-10 at the molecular level? 05/03/2021

NMR spectroscopy captures dynamic interactions, revealing the flexibility and movements of IL10RA and IL-10 during their binding events.

Could you provide insights into the comprehensive experimental methodologies, such as surface proteomics and mass spectrometry, used to identify potential IL10RA-interacting partners in complex cellular environments? 04/27/2021

Surface proteomics and mass spectrometry identify proteins physically interacting with IL10RA, providing insights into its complex functional networks.

What innovative approaches, such as proximity labeling and quantitative proteomics, are employed to uncover dynamic changes in IL10RA-associated protein networks upon IL-10 stimulation? 07/24/2020

Proximity labeling and quantitative proteomics unveil dynamic changes in IL10RA-associated proteins, shedding light on response mechanisms.

Could you explain the complex experimental methodologies employed to investigate the conformational changes in IL10RA upon ligand binding using techniques like X-ray crystallography and cryo-electron microscopy? 04/02/2020

X-ray crystallography and cryo-electron microscopy provide detailed structural insights into the changes in IL10RA's 3D arrangement upon binding to IL-10.

What advanced strategies, such as site-directed mutagenesis and alanine scanning, are used to pinpoint the critical amino acid residues in IL10RA that are essential for its interaction with IL-10? 03/07/2019

Site-directed mutagenesis and alanine scanning pinpoint key amino acids in IL10RA essential for IL-10 interaction, aiding in understanding binding determinants.

How do researchers leverage advanced genome-wide CRISPR screening techniques to systematically identify genes and pathways that modulate IL10RA expression and function in various physiological contexts? 07/01/2018

Genome-wide CRISPR screening identifies genes and pathways affecting IL10RA expression and function, aiding in understanding its regulatory network.

Can you elaborate on the sophisticated experimental approaches, such as co-immunoprecipitation and F枚rster resonance energy transfer (FRET), used to explore the formation of IL10RA-IL-10 receptor complexes? 07/19/2017

Co-immunoprecipitation and FRET techniques elucidate the assembly of multi-protein IL10RA-IL-10 receptor complexes in cellular environments.

What state-of-the-art experimental designs, including CRISPR/Cas9-edited cell lines and gene knockout models, are harnessed to study the downstream signaling cascades initiated by IL10RA activation? 03/15/2017

CRISPR/Cas9-modified cell lines and gene knockout models help dissect intricate signaling pathways activated by IL10RA upon ligand engagement.

Customer Reviews (3)

Write a review
Reviews
02/02/2021

    Good for receptor binding studies.

    11/19/2019

      Consistent in bioactivity.

      06/19/2017

        Suitable for ELISA.

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