IL10RA
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Official Full Name
interleukin 10 receptor, alpha -
Overview
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] -
Synonyms
IL10RA;interleukin 10 receptor, alpha;CD210;IL10R;CD210a;CDW210A;HIL-10R;IL-10R1;interleukin-10 receptor subunit alpha;IL-10RA;IL-10R subunit 1;IL-10R subunit alpha;IL-10 receptor subunit alpha;interleukin-10 receptor subunit 1;interleukin-10 receptor alpha chain
Recombinant Proteins
- Human
- Cynomolgus
- Rhesus macaque
- Mouse
- Chicken
- Zebrafish
- CHO
- HEK293
- E.coli
- C-His
- Sf21 Cells
- Mammalian Cells
- Insect Cells
- Human Cells
- Yeast
- HEK293T
- Fc
- GST
- His
- Non
- Avi
- DDK
- Myc
- SUMO
- Flag
Involved Pathway
IL10RA involved in several pathways and played different roles in them. We selected most pathways IL10RA participated on our site, such as Cytokine-cytokine receptor interaction,Epstein-Barr virus infection,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL10RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | OSTN,EPOR,BMP7,IL6ST,CCL21,Ccl21c,TGFBR1,ACVR2B,TNFRSF11A,VEGFC |
| Tuberculosis | CAMK2D,EP300,MRC1,AKT2,TRAF6,CD209A,IFNA5,CASP10,IFNA21,SPHK1 |
| Epstein-Barr virus infection | POLR3F,SND1,STAT3,PSMD2,GTF2B,HSPA2,MDM2,POLR2F,GTF2E1,ENTPD3 |
| Jak-STAT signaling pathway | PRLRA,HRASA,Ifnlr1,STAT4,STAT5B,EPO,CSF3R,RAF1,PIAS2,NT5C3 |
| Toxoplasmosis | MAPK12,HSPA2,Toxoplasma Gondii Microneme Protein MIC3,BIRC2,HLA-DRB5,LAMB4,LAMA3,RELA,CASP8,NFKB1 |
Protein Function
IL10RA has several biochemical functions, for example, interleukin-10 binding,interleukin-10 receptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL10RA itself. We selected most functions IL10RA had, and list some proteins which have the same functions with IL10RA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | DRD4A,GPR27,GNG10,OLFR998,LGALS1,V1RA8,GNG13A,STAT4,PPP5C,BAI2 |
| protein binding | ATP7A,BAG1,ISCU,CALCR,MYBL2,IMP4,LASP1,IGF1R,DOK1,EIF4EBP1 |
| receptor activity | OR3A2,GRIN3B,CD93,FPR3,MED30,RAMP3,TLR2,SLC20A1,VMN1R44,TEK |
Interacting Protein
IL10RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL10RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL10RA.
NS;il10h_ebvb9;UL111A;IL10;q6f051_bacan;dnaE;ilvC2
IL10RA Related Signal Pathway
Resources
Research Area
NeuroinflammationMultiple Sclerosis and Myelin Related Molecules
Negative Regulators of the Jak/STAT Pathway
Receptors in the Jak/STAT Pathway
T Follicular Helper (Tfh) Cells
IL-10 Family Receptors
Related Services
Related Products
References
- Matesanz-Isabel, J; Sintes, J; et al. New B-cell CD molecules. IMMUNOLOGY LETTERS 134:104-112(2011).
- Hennig, BJ; Fielding, K; et al. Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection. PLOS ONE 3:-(2008).
