• Official Full Name

    interleukin 28B

  • Background

    Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction of an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29. Their classification as Interferons is due to their ability to induce an antiviral state, while their additional classification as cytokines is due to their chromosomal location as well as the fact that they are encoded by multiple exons, as opposed to a single exon, as most type-I IFNs are.
  • Synonyms

    Cytokine Zcyto20;IFN lambda 2;IFNL2;IL28A;Interferon lambda 2;Interleukin 28A;ZCYTO20;Il28; IFL-1; IL-28B; INF-alpha; INF-lambda; interleukin-28B; IFN-lambda-3; interleukin 28; interferon alpha; interferon lambda-3; Il28b; interleukin 28B;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Equine
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Yeast
    • Tag :
    • His
    • His (Fc)
    • Avi
    • His|Myc
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Equine IL28B-4370E Recombinant Equine IL28B Protein Yeast N/A
    Human IL28B-605H Active Recombinant Human IL28B HEK293 N/A
    Human IL28B-600H Recombinant Human Interleukin 28B (interferon, lambda 3) HEK293 N/A
    Human IL28B-379H Recombinant Human IL28B, His tagged Human Cell His
    Human IL28B-2308H Recombinant Human IL28B Protein, His-tagged E.coli N-His
    Mouse Il28b-212M Recombinant Mouse Interleukin 28B E.coli N/A
    Mouse IL28B-4512M Recombinant Mouse IL28B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse IL28B-4512M-B Recombinant Mouse IL28B Protein Pre-coupled Magnetic Beads HEK293
    Mouse IL28B-65M Recombinant Mouse IL28B protein E.coli N/A
    Mouse IL28B-214M Recombinant Mouse Interleukin 28B, His-tag, MBP-tag E.coli His/Myc
    Mouse IL28B-8163M Recombinant Mouse IL28B Protein Mammalian Cell His
    Mouse Il28b-213M Recombinant Mouse Interleukin 28B, Carrier Free E.coli N/A
    • Il28b Related Articles
    • Il28b Related Gene Family
    • Il28b Related Research Area
    Oda, K; Uto, H; et al. Impact of a Single Nucleotide Polymorphism Upstream of the IL28B Gene in Patients Positive for Anti-HCV Antibody in an HCV Hyperendemic Area in Japan. JOURNAL OF MEDICAL VIROLOGY 86:1877-1885(2014).
    Seaberg, EC; Witt, MD; et al. Differences in hepatitis C virus prevalence and clearance by mode of acquisition among men who have sex with men. JOURNAL OF VIRAL HEPATITIS 21:696-705(2014).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    IL28B has made a breakthrough in treating what diseases? 04/18/2022

    IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.

    What is the mechanism of action of IL28B? 06/11/2021

    IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.

    IL28B purification ofs have? 05/19/2021

    The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.

    How many therapeutic doses of IL28B are usually used? 08/08/2020

    The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.

    What are the adverse reactions of IL28B? 07/15/2020

    The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.

    Does IL28B affect the function of other organs in the body? 01/10/2019

    IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.

    Customer Reviews (3)

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      Evaluate the purity of recombinant IL-28B protein to ensure that there are no impurities in it. -


        The regulation effect of recombinant IL-28B protein on cell signal transduction pathway, such as immune response and antiviral, was verified by cell experiments. To evaluate its blocking effect on pathogen infection and understand its potential in the treatment of infectious diseases. -


          To investigate the effect of recombinant IL-28B protein on the immune system and evaluate whether it can cause immune response, especially the production of neutralized antibodies. -

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