Il28b
-
Official Full Name
interleukin 28B
-
Background
Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction of an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29. Their classification as Interferons is due to their ability to induce an antiviral state, while their additional classification as cytokines is due to their chromosomal location as well as the fact that they are encoded by multiple exons, as opposed to a single exon, as most type-I IFNs are. -
Synonyms
Cytokine Zcyto20;IFN lambda 2;IFNL2;IL28A;Interferon lambda 2;Interleukin 28A;ZCYTO20;Il28; IFL-1; IL-28B; INF-alpha; INF-lambda; interleukin-28B; IFN-lambda-3; interleukin 28; interferon alpha; interferon lambda-3; Il28b; interleukin 28B;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Equine | IL28B-4370E | Recombinant Equine IL28B Protein | Yeast | N/A |
|
|
| Human | IL28B-605H | Active Recombinant Human IL28B | HEK293 | N/A |
|
|
| Human | IL28B-600H | Recombinant Human Interleukin 28B (interferon, lambda 3) | HEK293 | N/A |
|
|
| Human | IL28B-379H | Recombinant Human IL28B, His tagged | Human Cell | His |
|
|
| Human | IL28B-2308H | Recombinant Human IL28B Protein, His-tagged | E.coli | N-His |
|
|
| Mouse | Il28b-212M | Recombinant Mouse Interleukin 28B | E.coli | N/A |
|
|
| Mouse | IL28B-4512M | Recombinant Mouse IL28B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
|
|
| Mouse | IL28B-4512M-B | Recombinant Mouse IL28B Protein Pre-coupled Magnetic Beads | HEK293 |
|
||
| Mouse | IL28B-65M | Recombinant Mouse IL28B protein | E.coli | N/A |
|
|
| Mouse | IL28B-214M | Recombinant Mouse Interleukin 28B, His-tag, MBP-tag | E.coli | His/Myc |
|
|
| Mouse | IL28B-8163M | Recombinant Mouse IL28B Protein | Mammalian Cell | His |
|
|
| Mouse | Il28b-213M | Recombinant Mouse Interleukin 28B, Carrier Free | E.coli | N/A |
|
- Il28b Related Articles
- Il28b Related Gene Family
- Il28b Related Research Area
- Q&As
- Reviews
Q&As (6)
Ask a questionIL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.
IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.
The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.
The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.
The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.
IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.
Customer Reviews (3)
Write a reviewEvaluate the purity of recombinant IL-28B protein to ensure that there are no impurities in it. -
The regulation effect of recombinant IL-28B protein on cell signal transduction pathway, such as immune response and antiviral, was verified by cell experiments. To evaluate its blocking effect on pathogen infection and understand its potential in the treatment of infectious diseases. -
To investigate the effect of recombinant IL-28B protein on the immune system and evaluate whether it can cause immune response, especially the production of neutralized antibodies. -
Ask a Question for All Il28b Products
Required fields are marked with *
My Review for All Il28b Products
Required fields are marked with *