Il28b
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Official Full Name
interleukin 28B -
Overview
Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction of an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29. Their classification as Interferons is due to their ability to induce an antiviral state, while their additional classification as cytokines is due to their chromosomal location as well as the fact that they are encoded by multiple exons, as opposed to a single exon, as most type-I IFNs are. -
Synonyms
Cytokine Zcyto20;IFN lambda 2;IFNL2;IL28A;Interferon lambda 2;Interleukin 28A;ZCYTO20;Il28;IFL-1;IL-28B;INF-alpha;INF-lambda;interleukin-28B;IFN-lambda-3;interleukin 28;interferon alpha;interferon lambda-3;Il28b;interleukin 28B
Recombinant Proteins
- Human
- Equine
- Mouse
- HEK293
- Yeast
- E.coli
- Mammalian Cells
- His
- Non
- Myc
- Avi
- Fc
Involved Pathway
Il28b involved in several pathways and played different roles in them. We selected most pathways Il28b participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Il28b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
Il28b has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Il28b itself. We selected most functions Il28b had, and list some proteins which have the same functions with Il28b. You can find most of the proteins on our site.
| Function | Related Protein |
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Interacting Protein
Il28b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il28b here. Most of them are supplied by our site. Hope this information will be useful for your research of Il28b.
Resources
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References
- Oda, K; Uto, H; et al. Impact of a Single Nucleotide Polymorphism Upstream of the IL28B Gene in Patients Positive for Anti-HCV Antibody in an HCV Hyperendemic Area in Japan. JOURNAL OF MEDICAL VIROLOGY 86:1877-1885(2014).
- Seaberg, EC; Witt, MD; et al. Differences in hepatitis C virus prevalence and clearance by mode of acquisition among men who have sex with men. JOURNAL OF VIRAL HEPATITIS 21:696-705(2014).
