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  • Official Full Name

    interleukin 28B

  • Overview

    Interleukin-28 (IL-28) is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction of an "antiviral state" by turning on Mx proteins, 2',5'-oligoadenylate synthetase as well as ISGF3G (Interferon Stimulated Gene Factor 3). IL-28A and IL-28B belong to the type III interferon family of cytokines and are highly similar (in amino acid sequence) to IL-29. Their classification as Interferons is due to their ability to induce an antiviral state, while their additional classification as cytokines is due to their chromosomal location as well as the fact that they are encoded by multiple exons, as opposed to a single exon, as most type-I IFNs are.
  • Synonyms

    Cytokine Zcyto20;IFN lambda 2;IFNL2;IL28A;Interferon lambda 2;Interleukin 28A;ZCYTO20;Il28; IFL-1; IL-28B; INF-alpha; INF-lambda; interleukin-28B; IFN-lambda-3; interleukin 28; interferon alpha; interferon lambda-3; Il28b; interleukin 28B;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Equine
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Yeast
  • C
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL28B-605H Active Recombinant Human IL28B HEK293 N/A
Human IL28B-600H Recombinant Human Interleukin 28B (interferon, lambda 3) HEK293 N/A
Human IL28B-379H Recombinant Human IL28B, His tagged Human Cell His
Human IL28B-130H Active Recombinant Human IL28B Protein (Val22-Val196), C-His tagged, Animal-free, Carrier-free E.coli C-His Val22-Val196
Human IL28B-2308H Recombinant Human IL28B Protein, His-tagged E.coli N-His Val22-Val196
Mouse Il28b-212M Recombinant Mouse Interleukin 28B E.coli N/A
Mouse IL28B-8163M Recombinant Mouse IL28B Protein Mammalian Cell His
Mouse IL28B-214M Recombinant Mouse Interleukin 28B, His-tag, MBP-tag E.coli His/Myc
Mouse IL28B-65M Recombinant Mouse IL28B protein E.coli N/A 174
Mouse Il28b-213M Recombinant Mouse Interleukin 28B, Carrier Free E.coli N/A
Mouse IL28B-4512M-B Recombinant Mouse IL28B Protein Pre-coupled Magnetic Beads HEK293
Mouse IL28B-4512M Recombinant Mouse IL28B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il28b-153M Active Recombinant Mouse Il28b Protein (Asp20-Val193), C-His tagged, Animal-free, Carrier-free E.coli C-His Asp20-Val193
Equine IL28B-4370E Recombinant Equine IL28B Protein Yeast N/A 170aa
  • Il28b Related Articles
  • Il28b Related Gene Family
  • Il28b Related Research Area

Il28b involved in several pathways and played different roles in them. We selected most pathways Il28b participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Il28b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

Il28b has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by Il28b itself. We selected most functions Il28b had, and list some proteins which have the same functions with Il28b. You can find most of the proteins on our site.

Function Related Protein

Il28b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il28b here. Most of them are supplied by our site. Hope this information will be useful for your research of Il28b.

Oda, K; Uto, H; et al. Impact of a Single Nucleotide Polymorphism Upstream of the IL28B Gene in Patients Positive for Anti-HCV Antibody in an HCV Hyperendemic Area in Japan. JOURNAL OF MEDICAL VIROLOGY 86:1877-1885(2014).
Seaberg, EC; Witt, MD; et al. Differences in hepatitis C virus prevalence and clearance by mode of acquisition among men who have sex with men. JOURNAL OF VIRAL HEPATITIS 21:696-705(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
IL28B has made a breakthrough in treating what diseases? 04/18/2022

IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.

What is the mechanism of action of IL28B? 06/11/2021

IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.

IL28B purification ofs have? 05/19/2021

The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.

How many therapeutic doses of IL28B are usually used? 08/08/2020

The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.

What are the adverse reactions of IL28B? 07/15/2020

The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.

Does IL28B affect the function of other organs in the body? 01/10/2019

IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.

Customer Reviews (3)

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    Activity retention time is very long and can be maintained for a long time.


      High cost performance and low preparation cost.


        It has a wide range of applications and can be used in various biological experiments.

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