Active Recombinant Human IL28B
|Product Overview :||Interleukin-28B Human Recombinant produced in HEK cells is a non-glycosylated monomer, having a total molecular weight of 24kDa. The IL28B is purified by proprietary chromatographic techniques.|
- Gene Information
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|Description :||This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).|
|Source :||HEK cells|
|Formulation :||The IL28B was lyophilized from 1mg/ml in 1xPBS.|
|Bio-activity :||The specific activity was determined by the dose dependent protection of the cytopathic effect on A549 cells (human lung adenocarcinoma epithelial cell line) that were challenged with encephalomyocarditis (EMC) virus and is typically 0.1-1ng/ml.|
|Molecular Mass :||24 kDa|
|Physical Appearence :||Sterile Filtered White lyophilized (freeze-dried) powder.|
|Purity :||Greater than 95% as obsereved by SDS-PAGE.|
|Solubility :||It is recommended to reconstitute the lyophilized IL-28B in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.|
|Gene Name :||IFNL3 interferon, lambda 3 [ Homo sapiens (human) ]|
|Official Symbol :||IFNL3|
|Synonyms :||IFNL3; IL28B; IL28C; IL-28B; interferon, lambda 3; interferon lambda-3; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28B; interleukin-28C; cytokine Zcyto22; interferon lambda-4; interferon, lambda 4; interleukin 28B (interferon, lambda 3)|
|Gene ID :||282617|
|mRNA Refseq :||NM_172139|
|Protein Refseq :||NP_742151|
|UniProt ID :||Q8IZI9|
|Chromosome Location :||19q13.13|
|Pathway :||Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Type III interferon signaling|
|Function :||cytokine activity|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.
IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.
The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.
The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.
The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.
IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.
Customer Reviews (3)Write a review
Activity retention time is very long and can be maintained for a long time. -
High cost performance and low preparation cost. -
It has a wide range of applications and can be used in various biological experiments. -
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