Active Recombinant Human IL28B

Cat.No. : IL28B-605H
Product Overview : Interleukin-28B Human Recombinant produced in HEK cells is a non-glycosylated monomer, having a total molecular weight of 24kDa. The IL28B is purified by proprietary chromatographic techniques.
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Description : This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
Source : HEK cells
Species : Human
Formulation : The IL28B was lyophilized from 1mg/ml in 1xPBS.
Bio-activity : The specific activity was determined by the dose dependent protection of the cytopathic effect on A549 cells (human lung adenocarcinoma epithelial cell line) that were challenged with encephalomyocarditis (EMC) virus and is typically 0.1-1ng/ml.
Molecular Mass : 24 kDa
Physical Appearence : Sterile Filtered White lyophilized (freeze-dried) powder.
Purity : Greater than 95% as obsereved by SDS-PAGE.
Solubility : It is recommended to reconstitute the lyophilized IL-28B in sterile water not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Tag : Non
Gene Name : IFNL3 interferon, lambda 3 [ Homo sapiens (human) ]
Official Symbol : IFNL3
Synonyms : IFNL3; IL28B; IL28C; IL-28B; interferon, lambda 3; interferon lambda-3; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28B; interleukin-28C; cytokine Zcyto22; interferon lambda-4; interferon, lambda 4; interleukin 28B (interferon, lambda 3)
Gene ID : 282617
mRNA Refseq : NM_172139
Protein Refseq : NP_742151
MIM : 607402
UniProt ID : Q8IZI9
Chromosome Location : 19q13.13
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Type III interferon signaling
Function : cytokine activity

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
07/24/2022

    Activity retention time is very long and can be maintained for a long time.

    02/04/2022

      High cost performance and low preparation cost.

      01/24/2022

        It has a wide range of applications and can be used in various biological experiments.

        Q&As (6)

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        IL28B has made a breakthrough in treating what diseases? 04/18/2022

        IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.

        What is the mechanism of action of IL28B? 06/11/2021

        IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.

        IL28B purification ofs have? 05/19/2021

        The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.

        How many therapeutic doses of IL28B are usually used? 08/08/2020

        The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.

        What are the adverse reactions of IL28B? 07/15/2020

        The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.

        Does IL28B affect the function of other organs in the body? 01/10/2019

        IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.

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