Recombinant Mouse Interleukin 28B, His-tag, MBP-tag

• Cat.No.: IL28B-214M
• Product Overview: Recombinant Mouse Interleukin 28B has the matured 174 aa at its C terminal, His tag and MBP tag at the N terminal. It is expressed and purified from an E.coli system.

Specification

• Cat. No.: IL28B-214M
• Description: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
• Source: E. coli
• Molecular Mass: 63.3 kD
• Formulation: 20 mM Tris-Cl (pH 7.9) 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
• Purity: >95% based on SDS-PAGE analysis
• Concentration: 500 µg/ml
• Reconsitution: Already in liquid form.
• Storage: -80 °C
• Shipping Conditions: Dry Ice
• OfficialSymbol: Il28b
• Tag: His&Myc

Gene Information

• Gene Name: Il28b interleukin 28B [ Mus musculus ]
• Synonyms: Il28b; interleukin 28B; Il28; IFL-1; INF-alpha; IL-28B INF-lambda; interleukin 28; interferon alpha; IFNL3; IL28C; interleukin-28B; IFN-lambda-3; interferon lambda-3
• Gene ID: 338374
• mRNA Refseq: NM_177396
• Protein Refseq: NP_796370
• UniProt ID: Q8CGK6
• Chromosome Location: 7 A3; 7
• Pathway: Jak-STAT signaling pathway
• Function: cytokine activity; receptor binding

Reviews

07/24/2022

Activity retention time is very long and can be maintained for a long time.

02/04/2022

High cost performance and low preparation cost.

01/24/2022

It has a wide range of applications and can be used in various biological experiments.

Q&As

IL28B has made a breakthrough in treating what diseases?

IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.

What is the mechanism of action of IL28B?

IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.

IL28B purification ofs have?

The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.

How many therapeutic doses of IL28B are usually used?

The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.

What are the adverse reactions of IL28B?

The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.

Does IL28B affect the function of other organs in the body?

IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.