Recombinant Mouse IL28B protein

Cat.No. : IL28B-65M
Product Overview : Recombinant Mouse IL28B protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
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Description : This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
Source : E.coli
Species : Mouse
Form : Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.
Bio-activity : Fully biologically active when compared to standard. The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 30 ng/ml, corresponding to a specific activity of > 3.3 × 10⁴ IU/mg.
Molecular Mass : Approximately 19.6 kDa, a single non-glycosylated polypeptide chain containing 174 amino acids.
Protein length : 174
AA Sequence : DPVPRATRLPVEAKDCHIAQFKSLS PKELQAFKKAKGAIEKRLLEKDMRC SSHLISRAWDLKQLQVQERPKALQA EVALTLKVWENINDSALTTILGQPL HTLSHIHSQLQTCTQLQATAEPKPP SRRLSRWLHRLQEAQSKETPGCLED SVTSNLFQLLLRDLKCVASGDQCV
Endotoxin : Less than 1 EU/µg of rMuIFN-λ3/IL-28B as determined by LAL method.
Purity : >98% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : IL28B
Official Symbol : IL28B
Synonyms : IL28B; interleukin 28B; interleukin-28B; IFN-lambda-3; interleukin 28; interferon alpha; interferon lambda-3; Il28; IFL-1; IL-28B; INF-alpha; INF-lambda;
Gene ID : 338374
mRNA Refseq : NM_177396
Protein Refseq : NP_796370
UniProt ID : Q8CGK6

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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IL28B has made a breakthrough in treating what diseases? 04/18/2022

IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.

What is the mechanism of action of IL28B? 06/11/2021

IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.

IL28B purification ofs have? 05/19/2021

The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.

How many therapeutic doses of IL28B are usually used? 08/08/2020

The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.

What are the adverse reactions of IL28B? 07/15/2020

The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.

Does IL28B affect the function of other organs in the body? 01/10/2019

IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.

Customer Reviews (3)

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Reviews
07/24/2022

    Activity retention time is very long and can be maintained for a long time.

    02/04/2022

      High cost performance and low preparation cost.

      01/24/2022

        It has a wide range of applications and can be used in various biological experiments.

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