Recombinant Human IL28B Protein, His-tagged
|Product Overview :||Recombinant Human IL28B Protein (Val22-Val196) with a N-His tag was expressed in E. coli.|
- Gene Information
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|Description :||This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).|
|Source :||E. coli|
|Form :||Freeze-dried powder|
|Molecular Mass :||Predicted Molecular Mass: 21.6 kDa
Accurate Molecular Mass: 22 kDa
|Protein length :||Val22-Val196|
|Endotoxin :||<1.0 EU per 1µg (determined by the LAL method).|
|Purity :||> 95%|
|Applications :||Cell culture; Activity Assays.|
|Stability :||The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.|
|Storage :||Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.|
|Storage Buffer :||20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.|
|Reconstitution :||Reconstitute in 20mM Tris, 150mM NaCl (PH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.|
|Gene Name :||IL28B interleukin 28B (interferon, lambda 3) [ Homo sapiens (human) ]|
|Official Symbol :||IL28B|
|Synonyms :||IL28B; interleukin 28B (interferon, lambda 3); interleukin 28B; interleukin-28B; IFNL3; IL 28B; IL28C; IL-28C; IFN-lambda-3; IFN-lambda-4; interleukin 28C; interleukin-28C; cytokine Zcyto22; interferon lambda-3; interferon lambda-4; interferon, lambda 3; interferon, lambda 4; IL-28B;|
|Gene ID :||282617|
|mRNA Refseq :||NM_172139|
|Protein Refseq :||NP_742151|
|UniProt ID :||Q8IZI9|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.
IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.
The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.
The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.
The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.
IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.
Customer Reviews (3)Write a review
Activity retention time is very long and can be maintained for a long time. -
High cost performance and low preparation cost. -
It has a wide range of applications and can be used in various biological experiments. -
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