Recombinant Mouse Interleukin 28B

• Cat.No.: Il28b-212M

Specification

• Cat. No.: Il28b-212M
• Description: IL-28A, IL-28B, and IL-29, also named interferon-λ2 (IFN-λ2), IFN-λ3, and IFN-λ1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11-13% aa sequence identity) and type I IFN family (15 - 19% aa sequence identity).
• Source: DNA expressed inE.Coli.
• Endotoxin: < 1 EU/µg.
• Reconstitution: It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10 μg/mL.
• Buffer: Phosphate-buffered saline (PBS) containing 50µg of BSA per 1µg of cytokine.
• Purity: ≥95%.
• Purification Method: A combination of ion exchange, hydrophobic interaction and size exclusion chromatography.
• Shipping Conditions: Wet ice, Physical State of Product During Shipping is Lyophilized.
• Special Conditions: After receipt, this product should be kept at -70˚C or below for retention of full activity. Upon reconstitution, this cytokine can be stored under sterile conditions at 2˚C to 8˚C for one month or at -20˚C to -70˚C in a manual defrost freezer for three months without detection loss of activity. Avoid repeated freeze-thaw cycles.
• Tag: Non

Gene Information

• Gene Name: Il28b interleukin 28B [ Mus musculus ]
• Synonyms: Il28b; interleukin 28B; Il28; IFL-1; INF-alpha; INF-lambda; interleukin 28; interferon alpha
• Gene ID: 338374
• mRNA Refseq: NM_177396
• Protein Refseq: NP_796370
• UniProt ID: Q8CGK6
• Chromosome Location: 7 A3
• Pathway: Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
• Function: cytokine activity; receptor binding

Reviews

07/24/2022

Activity retention time is very long and can be maintained for a long time.

02/04/2022

High cost performance and low preparation cost.

01/24/2022

It has a wide range of applications and can be used in various biological experiments.

Q&As

IL28B has made a breakthrough in treating what diseases?

IL28B has achieved remarkable results in the treatment of hepatitis C. The study found that patients with a specific genotype, which is related to IL28B, were better able to benefit from treatment with the hepatitis drug interferon. Therefore, the combination of IL28B with other drugs can improve the efficacy.

What is the mechanism of action of IL28B?

IL28B can regulate the immune response of cells and promote the occurrence of insulin-dependent cytotoxicity mediated by NK cells, thus playing an antiviral role.

IL28B purification ofs have?

The purification methods of IL28B include ion exchange, gel filtration, affinity chromatography, countercurrent chromatography, etc.

How many therapeutic doses of IL28B are usually used?

The dose of treatment with IL28B varies depending on the patient. When treating hepatitis C, the dose is usually given once a week, 500ug or another dose.

What are the adverse reactions of IL28B?

The adverse reactions of IL28B include fever, headache, fatigue, muscle aches, nausea, diarrhea and other symptoms, and in severe cases, allergic reactions and liver damage.

Does IL28B affect the function of other organs in the body?

IL28B will have a certain impact on the function of other organs of the body, such as the liver, kidneys, etc., but the use of normal doses in clinical practice is generally safe.