• Official Full Name

    interleukin 36, beta

  • Background

    The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms

    2310043N20Rik; Family of interleukin 1 eta; FIL1; FIL1 (ETA); FIL1 eta; FIL1H; FILI-(ETA); IL 1F8; IL 1F8 (FIL1 eta; IL 1H2; IL-1 eta; IL-1F8; IL-1H2; IL1 ETA; IL1F8; IL1F8 (Canonical product IL 1F8a); IL1F8_HUMAN; IL1H2; IL36B; Interleukin 1 family, member 8; Interleukin 1 family, member 8 (eta); Interleukin 1 homolog 2; Interleukin 1 Superfamily e; Interleukin 36 beta; Interleukin-1 eta; Interleukin-1 family member 8; Interleukin-1 homolog 2; MGC126880; MGC126882; OTTMUSP00000012797; RP23-176J12.1; IL1-ETA; FIL1-(ETA);
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Species :
    • Human
    • Mouse
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Tag :
    • GST
    • His
    • His(C
    • ter)
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL1F8-14172H Recombinant Human IL1F8, GST-tagged E.coli GST
    Human IL36B-508H Recombinant Human IL36B protein E.coli N/A
    Human IL36B-197H Recombinant Active Human IL36B Protein, His-tagged(C-ter) E.coli His(C-ter)
    Human IL36B-5236HCL Recombinant Human IL1F8 293 Cell Lysate HEK293 N/A
    Human IL36B-509H Recombinant Human IL36B protein E.coli N/A
    Human IL36B-752H Recombinant Human IL36B, None tagged E.coli N/A
    Human IL36B-7518H Recombinant Human IL36B, His tagged E.coli His
    Human IL36B-140H Active Recombinant Human IL36B protein E.coli N/A
    Human IL36B-852H Active Recombinant Human IL36B E.coli N/A
    Human IL36B-7519H Recombinant Human IL36B protein, His-tagged E. coli His
    Human IL36B-151H Recombinant Human IL36B Protein, His-tagged Human Cells His
    Mouse Il1f8-647M Recombinant Mouse Il1f8 protein E.coli N/A
    Mouse Il36b-3507M Recombinant Mouse Il36b Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Il1f8-646M Recombinant Mouse Il1f8 protein E.coli N/A
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL36B Related Articles
    • IL36B Related Gene Family
    • IL36B Related Research Area

    IL36B involved in several pathways and played different roles in them. We selected most pathways IL36B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL36B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    IL36B has several biochemical functions, for example, cytokine activity, interleukin-1 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL36B itself. We selected most functions IL36B had, and list some proteins which have the same functions with IL36B. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityTNFB;NRG1;GDF9;BMP7A;CXCL9;GPI1;TNFSF13B;GDF10;IFNA21
    interleukin-1 receptor bindingIL1RN;IL1RAP;IL1F10;IRAK4;Il1f6;IL37;TLR9;IL1A;IL36RN

    IL36B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL36B here. Most of them are supplied by our site. Hope this information will be useful for your research of IL36B.

    Hu, ZL; Chen, ZY; et al. Expression, purification of IL-38 in Escherichia coli and production of polyclonal antibodies. PROTEIN EXPRESSION AND PURIFICATION 107:76-82(2015).
    Chen, DY; Chen, YM; et al. Th17-Related Cytokines in Systemic Lupus Erythematosus Patients with Dilated Cardiomyopathies: A Possible Linkage to Parvovirus B19 Infection. PLOS ONE 9:-(2014).
    • Q&As
    • Reviews

    Q&As (6)

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    What are the research topics related to IL36B? 06/28/2022

    Research topics related to IL36B include in-depth study of its signal transduction mechanism, evaluation of therapeutic efficacy, and comparison with other therapeutic approaches.

    What is the action mechanism of IL36B? 04/08/2022

    IL36B exerts its therapeutic role by binding to its receptors, activating signaling pathways and regulating inflammatory and immune responses.

    How long does the effect of IL36B last? 09/07/2021

    The duration of the IL36B's efficacy will vary from individual to individual, and regular treatment is usually required to maintain the effect.

    Are there other treatments similar to IL36B? 09/17/2020

    Yes, there are other treatments similar to IL36B, such as antibody drugs and small molecule compounds.

    How to determine the dosage and frequency of IL36B? 12/03/2019

    The dosage and frequency of use are determined according to the specific circumstances of the patient and the results of the clinical trial, and are usually adjusted on an individual basis based on the clinical trial.

    How was the IL36B developed and used in production? 05/16/2019

    The development process of IL36B includes basic research, drug screening, clinical trials and other stages, and has been developed after long-term efforts

    Customer Reviews (3)

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      Ultraviolet absorption spectra (UV) and fluorescence spectra were used to understand the absorption and fluorescence properties of IL-36B under different conditions. -


        Through crystallographic analysis, the three-dimensional structure of IL-36B can be revealed, providing detailed information about its molecular conformation and spatial arrangement. -


          It was detected under different temperature and time conditions to observe the change of its thermal stability. -

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