Ino80

  • Official Full Name

    INO80

  • Overview

    DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle.

  • Synonyms

    4632409L19Rik;DNA helicase INO80;hINO80;homolog of yeast INO80;INO80;INO80 complex subunit A;INO80 homolog;INO80A;INOC1;KIAA1259;Putative DNA helicase INO80 complex homolog 1
Cat.# Product name Source (Host) Species Tag Protein Length Price
INO80-116H Recombinant Human INO80, GST-tagged E.coli Human GST 1217-1556aa
INO80-4161Z Recombinant Zebrafish INO80 Mammalian Cells Zebrafish His
INO80-4447C Recombinant Chicken INO80 Mammalian Cells Chicken His
INO80-14 INO80 E.coli Non

    Involved Pathway

    Ino80 involved in several pathways and played different roles in them. We selected most pathways Ino80 participated on our site, such as DNA Damage Recognition in GG-NER,DNA Repair,Global Genome Nucleotide Excision Repair (GG-NER), which may be useful for your reference. Also, other proteins which involved in the same pathway with Ino80 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Damage Recognition in GG-NER YY1,COPS4,COPS6,PARP2,INO80E,DDB2,CETN2,COPS8,COPS3,GPS1
    Global Genome Nucleotide Excision Repair (GG-NER) ACTR5,YY1A,YY1,GPS1,COPS8,COPS7A,ACTL6A,MCRS1,COPS6,COPS3
    Nucleotide Excision Repair ERCC8,GTF2H1,CUL4B,ERCC1,POLD1,GTF2H3-2,ERCC5,RAD23A,POLE4,GPS1
    DNA Repair KIAA1530,RNF4,ASCC1,ZNF830,ZBTB32,CHEK1,TDP2,COPS2,TCEA1,RIF1

    Protein Function

    Ino80 has several biochemical functions, for example, ATP binding,ATPase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ino80 itself. We selected most functions Ino80 had, and list some proteins which have the same functions with Ino80. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding VPS4A,ATP13A3,TOR1A,PRKCHB,SMC2,CHD8,MAPK9,PDK1,PIK3C3,UBE2K
    DNA helicase activity MCM6L,RECQL5,ATRX,FBXO18,MCM5,MCM2,RUVBL2,MCM3,DNA2,MCM3L
    actin binding CAPG,MYBPC3,PARVG,MYO1F,PHACTR1,UPF3B,GCET2,SMYHC1,CCR5,PHACTR3
    alpha-tubulin binding C9orf24,RACGAP1,BBS4,FNTA,FAM110C,HDAC6,NCALD,SLC6A2,CAV3,PROL1
    protein binding GATSL3,CDCA5,ERAL1,ARF4,MTNR1A,IRS2,STXBP2,TRAPPC6A,WDR25,PHF20L1
    ATPase activity DNAH6,KIF9,PMS1,KIF23,KIF21A,KIF2A,PSMC4,KIFC3,NSFB,KIF6
    DNA binding ZIC5,ZNF707,ARID3C,GLI1,SOX32,FOXP1A,MIER1B,ABL1,TBX22,NKX2.1

    Interacting Protein

    Ino80 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ino80 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ino80.

    ACTR5;INO80E;YY1;DDB1;ACTL6A

    Resources

    Research Area

    INO80 Family

    References

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