ITGA1

  • Official Full Name

    integrin, alpha 1

  • Overview

    This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to;form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion;and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor;type I domain which is thought to be involved in collagen binding.

  • Synonyms

    ITGA1;integrin, alpha 1;integrin alpha-1;CD49a;VLA1;VLA-1;laminin and collagen receptor;very late activation protein 1;CD49 antigen-like family member A

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Mouse
  • Wheat Germ
  • Mammalian Cells
  • E.coli
  • HEK293
  • CHO
  • Non
  • His
  • T7
  • Avi
  • Fc
  • GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
ITGA1-29494TH Recombinant Human ITGA1 Wheat Germ Human Non 109 amino acids
ITGA1-3111R Recombinant Rat ITGA1 Protein Mammalian Cells Rat His
ITGA1-6626C Recombinant Chicken ITGA1 Mammalian Cells Chicken His
ITGA1-6796C Recombinant Chicken ITGA1 protein, His & T7-tagged E.coli Chicken His&T7 Lys113~Trp380
ITGA1-6797H Recombinant Human ITGA1 protein, His-tagged E.coli Human His Gly125~Ala366
Itga1-6798M Recombinant Mouse Itga1 protein, His-tagged E.coli Mouse His Ile103~Gln368
Itga1-6799R Recombinant Rat Itga1 protein, His & T7-tagged E.coli Rat His&T7 Leu119~Leu355
ITGA1-5137HCL Recombinant Human ITGA1 293 Cell Lysate HEK293 Human Non
ITGA1-2767R Recombinant Rat ITGA1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ITGA1-2767R-B Recombinant Rat ITGA1 Protein Pre-coupled Magnetic Beads HEK293 Rat
ITGA1-27H Active Recombinant Human ITGA1 Protein, C-6×His-tagged CHO Human His Integrin alpha 1: Met1-Pro1141<br />Integrin beta 1: Gln21-Asp728
ITGA1-4316H Recombinant Human ITGA1 Protein (Met1-Pro1141), C-His tagged Mammalian Cells Human His Met1-Pro1141
ITGA1-5002H Recombinant Human ITGA1 Protein, GST-tagged Wheat Germ Human GST

    Involved Pathway

    ITGA1 involved in several pathways and played different roles in them. We selected most pathways ITGA1 participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hematopoietic cell lineage Kitl,GP1BA,FLT3,Itga10&Itgb1,ITGA5,IL1B,Il4ra,CD1E,ITGAM,CD34
    Focal adhesion ILK,VAV1,PDPK1,RAC3,PAK4,COL1A1A,PAK2,ITGA2B,BCL2,VWF
    ECM-receptor interaction ITGA8,COL11A2,GP5,THBS4A,THBS3,ITGA4,GP1BB,SV2B,TNXB,COMP
    PIK-Akt signaling pathway SGK3,NFKB1,GNG3,RPS6KB2,IBSP,PPP2R3A,CASP9,PDGFA,MCL1,GNG12
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNA2D1,ITGB1,LAMA2,DAG1,ITGA3,ACTB,CACNB3,CACNA2D4,CACNG8,CACNB4
    Dilated cardiomyopathy TPM3,ITGA7,SGCG,DMD,ATP2A2,MYL3,ITGA2B,CACNB1,ITGB1,CACNG4
    Hypertrophic cardiomyopathy (HCM) CACNA2D3,ITGA2B,TNNC1,ACE,ITGB1,CACNG3,ITGA9,TNF,DMD,PRKAA1
    Regulation of Actin Cytoskeleton SCINLB,ACTG1,FGF13,FGF1A,ITGA6,ROCK2A,MYL5,RRAS,FGF11,ROCK1

    Protein Function

    ITGA1 has several biochemical functions, for example, collagen binding,collagen binding involved in cell-matrix adhesion,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA1 itself. We selected most functions ITGA1 had, and list some proteins which have the same functions with ITGA1. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding PAPOLB,RORAA,PDE10A,RNF11B,Itga10&Itgb1,PLAGX,TPP1,UNC13C,MYBPC3,PPP2CA
    protein phosphatase binding STAT3,ERBB2,CTNNB1,VCP,EGFR,AP3B1,RPA2,NEK2,EIF2AK3,DRD1
    protein binding CCND3,INTS5,NR2C2AP,PSMD3,ASB6,LARP4,ATF6,HGF,ZNF426,PSG5
    collagen binding ITGA9,LACRT,ASPN,HSD17B12,ITGA10,LUM,ABI3BP,ACHE,SMAD7,SERPINH1
    collagen binding involved in cell-matrix adhesion ITGA2,ITGA10,ITGB1,Itga10&Itgb1
    receptor binding FGF20A,TAC1,EHHADH,ANXA1,UCN2,FASLG,ARPP19A,RSPO1,ANGPTL1,CRTAM

    Interacting Protein

    ITGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA1.

    PTPN2;FABP3;Rab21;Sharpin;Fabp3;proS;terA;Iqgap3;Hax1;Itgb1;LIMK1;Magoh;FAM178A;Csnk1d;Gnpnat1

    Resources

    Research Area

    Integrins
    Focal Adhesion Proteins in VSMC
    Mesenchymal Cells and EMT
    Integrins in Focal Adhesions
    Basolateral Molecules

    References

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