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ITGA1

  • Official Full Name

    integrin, alpha 1

  • Overview

    This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to;form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion;and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor;type I domain which is thought to be involved in collagen binding.
  • Synonyms

    ITGA1; integrin, alpha 1; integrin alpha-1; CD49a; VLA1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • 6×His
  • His
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGA1-29494TH Recombinant Human ITGA1 Wheat Germ N/A 109 amino acids
Human ITGA1-6797H Recombinant Human ITGA1 protein, His-tagged E.coli His Gly125~Ala366
Human ITGA1-5137HCL Recombinant Human ITGA1 293 Cell Lysate HEK293 N/A
Human ITGA1-5002H Recombinant Human ITGA1 Protein, GST-tagged Wheat Germ GST
Human ITGA1-27H Active Recombinant Human ITGA1 Protein, C-6×His-tagged CHO C-6×His Integrin alpha 1: Met1-Pro1141<br />Integrin beta 1: Gln21-Asp728
Human ITGA1-4316H Recombinant Human ITGA1 Protein (Met1-Pro1141), C-His tagged Mammalian cells C-His Met1-Pro1141
Mouse Itga1-6798M Recombinant Mouse Itga1 protein, His-tagged E.coli His Ile103~Gln368
Rat ITGA1-3111R Recombinant Rat ITGA1 Protein Mammalian Cell His
Rat Itga1-6799R Recombinant Rat Itga1 protein, His & T7-tagged E.coli His/T7 Leu119~Leu355 (Accession # P18614)
Rat ITGA1-2767R Recombinant Rat ITGA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ITGA1-2767R-B Recombinant Rat ITGA1 Protein Pre-coupled Magnetic Beads HEK293
Chicken ITGA1-6626C Recombinant Chicken ITGA1 Mammalian Cell His
Chicken ITGA1-6796C Recombinant Chicken ITGA1 protein, His & T7-tagged E.coli His/T7 Lys113~Trp380 (Accession # Q90615)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITGA1 Related Research Area

ITGA1 involved in several pathways and played different roles in them. We selected most pathways ITGA1 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayFLT4;LPAR6;LAMB2;IFNA8;THBS3;PRLR;COL6A4;FGF16;LAMB4
Focal adhesionCOL24A1;FYNB;TNW;FLNA;CAPN2;MAPK9;RHOAC;SHC3;LAMA2
ECM-receptor interactionVTN;ITGA9;COL4A6;GP1BB;LAMB3;GP6;COL6A4;DAG1;COL4A4
Hematopoietic cell lineageITGA2;MME;CR1;CD7;GP5;CD3E;Fcer2a;IL6R;ITGA5
Regulation of actin cytoskeletonITGA9;EZR;PPP1CC;ARHGEF7;ACTN3A;CFL2;PIK3R5;WASL;PIP5K1BA
Hypertrophic cardiomyopathy (HCM)TPM3;TGFB3;TGFB1;DAG1;ITGA8;CACNA2D4;PRKAA1;TNNC1;CACNA2D3
Arrhythmogenic right ventricular cardiomyopathy (ARVC)LMNA;ITGA3;ATP2A2;CACNG3;DES;CDH2;DSC2;PKP2;DAG1
Dilated cardiomyopathyTNNI3;TGFB2;EMD;MYH7;ITGA6;CACNB1;PRKACB;ITGA7;ITGA2

ITGA1 has several biochemical functions, for example, collagen binding, collagen binding involved in cell-matrix adhesion, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA1 itself. We selected most functions ITGA1 had, and list some proteins which have the same functions with ITGA1. You can find most of the proteins on our site.

Function Related Protein
collagen bindingSERPINH1B;PCOLCE;ACHE;ANTXR1;SMAD7;SMAD4;GP5;CTSS;MMP9
collagen binding involved in cell-matrix adhesionITGA10;Itga10&amp;Itgb1;ITGB1;ITGA2;ITGA1
metal ion bindingZNF580;ELOF1;RPS27L;ZXDB;MT1;ZNF583;PAPL;ATP9A;ARSE
protein bindingMPZL2B;PDZD7;NXT1;ZZZ3;MYH7B;TTN;CCDC12;SMURF2;CSK
protein phosphatase bindingJUPA;VCAN;JUP;IRS2;EGFR;MET;TRAF2;TRAF3;CTNNB1
receptor bindingACOX2;BMP3;PLA2G1B;ARRB2;WNT7A;HACL1;CRH;MAG;ANGPTL2

ITGA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA1.

PTPN2; FABP3; Rab21; Sharpin; Fabp3; proS; terA; Iqgap3; Hax1; Itgb1; LIMK1; Magoh; FAM178A; Csnk1d; Gnpnat1

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