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Official Full Name integrin, alpha 1
Background This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to;form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion;and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor;type I domain which is thought to be involved in collagen binding.
Synonyms ITGA1; integrin, alpha 1; integrin alpha-1; CD49a; VLA1; VLA-1; laminin and collagen receptor; very late activation protein 1; CD49 antigen-like family member A
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGA1-29494TH Recombinant Human ITGA1 Wheat Germ N/A
    Human ITGA1-5002H Recombinant Human ITGA1 Protein, GST-tagged Wheat Germ GST
    Human ITGA1-5137HCL Recombinant Human ITGA1 293 Cell Lysate HEK293 N/A
    Human ITGA1-6797H Recombinant Human ITGA1 protein, His-tagged E.coli His
    Mouse Itga1-6798M Recombinant Mouse Itga1 protein, His-tagged E.coli His
    Rat ITGA1-3111R Recombinant Rat ITGA1 Protein Mammalian Cell His
    Rat Itga1-6799R Recombinant Rat Itga1 protein, His & T7-tagged E.coli His/T7
    Chicken ITGA1-6626C Recombinant Chicken ITGA1 Mammalian Cell His
    Chicken ITGA1-6796C Recombinant Chicken ITGA1 protein, His & T7-tagged E.coli His/T7

    itga1 involved in several pathways and played different roles in them. We selected most pathways itga1 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with itga1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway GSK3B; TNC; PPP2R5E; YWHAH; GNG4; LAMA3; HRAS; IL7R; TCL1B1; SGK1
    Focal adhesion PIK3R3; PXN; CDC42; MYL12.2; MYL2; MAP2K1; ACTN3B; LAMA4; ITGB3B; CCND3
    ECM-receptor interaction SDC1; LAMB1A; TNN; ITGA2B; COL27A1A; Itga10&Itgb1; FN1A; GP9; IBSP; HSPG2
    Hematopoietic cell lineage IL5; FLT3; GYPA; ITGA5; ITGA1; CD1d1; CD9; EPO; IL1B; Cd24a
    Regulation of actin cytoskeleton ITGB1A; ACTB2; PIK3CB; INS; CFL2; PIP5K1BA; WASLA; ITGA6; ITGA3; ARHGEF12
    Hypertrophic cardiomyopathy (HCM) ITGB6; IGF1; ITGA7; SGCD; CACNA2D3; ITGB5; SLC8A1; DMD; PRKAA1; CACNA2D2
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ITGA9; ITGB8; TCF7L2; ITGA1; DMD; ACTN2; CACNA2D1; EMD; CTNNA3; SLC8A1
    Dilated cardiomyopathy PRKACA; RYR2; ACTB; CACNG6; CACNG2; PRKACB; CACNB2; SGCA; TPM1; TPM3

    itga1 has several biochemical functions, for example, collagen binding, collagen binding involved in cell-matrix adhesion, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by itga1 itself. We selected most functions itga1 had, and list some proteins which have the same functions with itga1. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding PAK1; ACHE; Pdgfa&Pdgfb; CTSK; DDR2; ANTXR1; GPR56; GP6; SPARC; ITGA2
    collagen binding involved in cell-matrix adhesion ITGB1; ITGA10; Itga10&Itgb1; ITGA2; ITGA1
    metal ion binding EBF1; ZFP932; COL3A1; SUCLA2; FAH; TGM4; ZNF234; NAALAD2; HBAA1; ZFP541
    protein binding CDKN2AIP; IL15; C2orf62; RUFY3; FBXO9; GRM6; MEF2A; SEC22A; NCF1; NLGN4Y
    protein phosphatase binding DLG3; VCP; AP3B1; PPP1R3G; Itga10&Itgb1; GRB2; JAK1; STAT6; PIK3R1; PPP6R1
    receptor binding MCHR1; PVRL2; FZD8; ADM; CALCA; LAMA4; A2M; CADM2; NRG1; PPY

    itga1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with itga1 here. Most of them are supplied by our site. Hope this information will be useful for your research of itga1.

    PTPN2; FABP3; Rab21; Sharpin; Fabp3; proS; terA; Iqgap3; Hax1; Itgb1; LIMK1; Magoh; FAM178A; Csnk1d; Gnpnat1

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