• Official Full Name

    integrin, alpha M (complement component 3 receptor 3 subunit)

  • Overview

    This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ITGAM; integrin, alpha M (complement component 3 receptor 3 subunit); CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6; integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGAM&ITGB2-692H Active Recombinant Human ITGAM&ITGB2 CHO N/A
Human ITGAM-4257H Recombinant Human Integrin, Alpha M (Complement Component 3 Receptor 3 Subunit) Human N/A
Human ITGAM-28H Recombinant Human ITGAM protein, His-tagged HEK293 His
Human ITGAM-231H Recombinant Human ITGAM, GST-tagged Wheat Germ GST
Human ITGAM-1798H Recombinant Human ITGAM protein, His & GST-tagged E.coli His/GST Asn301~Thr451 (Accession # P11215)
Human ITGAM-1799H Recombinant Human ITGAM protein, His-tagged E.coli His Asn301~Thr451 (Accession # P11215)
Human ITGAM-1064H Recombinant Human ITGAM Protein, His&GST-tagged E.coli N-His&GST Pro145-Gly337
Human ITGAM-151H Recombinant Human ITGAM Protein, His-tagged Human Cells His
Human ITGAM-2649H Recombinant Human ITGAM Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ITGAM-1065H Recombinant Human ITGAM Protein, His-tagged HEK293F N-His Pro145-Gly337
Human ITGAM-264HF Recombinant Full Length Human ITGAM Protein, GST-tagged In Vitro Cell Free System GST 111 a.a. - 220 a.a.
Human ITGAM-1215H Recombinant Human ITGAM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ITGAM-737HFL Recombinant Full Length Human ITGAM Protein, C-Flag-tagged Mammalian cells Flag
Human ITGAM-1215H-B Recombinant Human ITGAM Protein Pre-coupled Magnetic Beads HEK293
Human ITGAM-2635H Recombinant Human ITGAM protein(131-350 aa), N-SUMO & C-His-tagged E.coli N-SUMO & C-His 131-350 aa
Human ITGAM-1060H Recombinant Human ITGAM Protein (Gln133-Gly337), N-His tagged E.coli N-His Gln133-Gly337
Human ITGAM-432H Recombinant Human ITGAM protein, His-GST-tagged E.coli N-His-GST 46-150aa
Human ITGAM-4322H Recombinant Human ITGAM Protein (Met1-Asn1104), C-His tagged Mammalian cells C-His Met1-Asn1104
Human CDA082P Recombinant Human CD-11b E.coli N/A
Mouse Itgam&Itgb2-605M Active Recombinant Mouse Itgam&Itgb2 CHO N/A
Mouse Itgam-1800M Recombinant Mouse Itgam protein, His-tagged E.coli His Asn248~Gly430 (Accession # P05555)
Mouse Itgam-3602M Recombinant Mouse Itgam Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Itgam-1801R Recombinant Rat Itgam protein, His-tagged E.coli His Ala31~Ser160 (Accession # G3V8L7)
Rat Itgam-1802R Recombinant Rat Itgam protein, His-tagged E.coli His Phe870~Pro1004 (Accession # G3V8L7)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ITGAM involved in several pathways and played different roles in them. We selected most pathways ITGAM participated on our site, such as Rap signaling pathway, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hematopoietic cell lineageHLA-DRB1;THPO;MS4A1;HLA-DRA;CD7;IL11RA;IL5RA;CD22;CD8A
Leukocyte transendothelial migrationPIK3R3;MYL10;CTNNA3;NCF1;CLDN10;ESAM;PXN;CYBB;VCL
Regulation of actin cytoskeletonWASLA;EZRB;MYLK;RAF1A;ITGB5;MYL1;ACTN2;RAC1B;PIKFYVE
Staphylococcus aureus infectionSELPLG;HLA-DMB;FCGR2B;HLA-DRB1;H2-AA;C1S;C3;FCGR3;H2-AB1
TuberculosisTLR9;ATP6V0D2;BCL2;PLK3;HSPA9;IFNG;PPP3CA;HLA-DMB;Il23a; Il12b
Transcriptional misregulation in cancerFLT3;MEF2C;SUPT3H;CDK14;SS18;ELK4;BCL2A1A;PBX1;ID2

ITGAM has several biochemical functions, for example, glycoprotein binding, heparan sulfate proteoglycan binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGAM itself. We selected most functions ITGAM had, and list some proteins which have the same functions with ITGAM. You can find most of the proteins on our site.

Function Related Protein
heparan sulfate proteoglycan bindingGPC6A;ITGAM;GPC6;GPC4;COMP;AGRN;HPSE2;UBE4A;SEMA5A
metal ion bindingZFP322A;COX4I2;KSR2;ZNF865;HDHD1A;ZNF35;ACLY;HENMT1;SOBPB
opsonin bindingCLEC7A;ITGAM;Itgam&Itgb2
protein bindingMRPL1;ACSS1;NEK8;RNF31;RAB5B;LATS1;MAGEB18;TTR;MCM8

ITGAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGAM here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGAM.

CLEC4M; fibrinogen_human_complex; crlkekhc

Research Area

Related articles

Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
Rosetti, F; Chen, YF; et al. A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force. CELL REPORTS 10:1655-1664(2015).
  • Q&As
  • Reviews

Q&As (7)

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How does ITGAM contribute to the adhesion and migration of leukocytes? 02/11/2022

It facilitates leukocyte adhesion to blood vessel walls and migration to sites of inflammation or infection.

What potential therapeutic applications arise from targeting ITGAM in immune-related disorders? 04/14/2020

Targeting ITGAM could provide new treatments for autoimmune and inflammatory diseases by modulating immune cell activity.

How do genetic variations in ITGAM affect immune responses and susceptibility to autoimmune diseases? 03/01/2020

Genetic mutations in ITGAM can lead to altered immune functioning, increasing the risk of autoimmune diseases.

What role does ITGAM play in the immune system's response to infection? 11/02/2019

ITGAM plays a key role in the immune system's ability to combat infections and clear pathogens.

How does ITGAM interact with other components of the immune system? 12/21/2018

ITGAM works in concert with other immune system components to orchestrate a coordinated response to threats.

What is the primary role of ITGAM in immune cell function? 04/08/2018

ITGAM, integral to leukocyte function, is crucial for mediating immune cell adhesion and phagocytosis.

What is the impact of altered ITGAM activity on inflammatory processes? 04/04/2017

Altered ITGAM activity can exacerbate or diminish inflammatory responses, affecting disease progression.

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