Jam3

  • Official Full Name

    junctional adhesion molecule 3

  • Overview

    Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, the this protein is unable to adhere to leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family. A mutation in an intron of this gene is associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts. Alternative splicing results in multiple transcript variants.
  • Synonyms

    JAM3; junctional adhesion molecule 3; junctional adhesion molecule C; JAM C; JAMC; FLJ14529; JAM 2; JAM 3; JAM2; Junctional adhesion molecule 3 precursor; JAM-2; JAM-3; OTTHUMP00000235250; OTTHUMP00000235251; JAM-C;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • hFc
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human JAM3-496H Recombinant Human JAM3 Protein, Fc-tagged HEK293 Fc
Human JAM3-7155H Recombinant Human Junctional Adhesion Molecule 3, His-tagged E.coli His 32-241aa
Human JAM3-497H Recombinant Human JAM3 Protein HEK293 N/A
Human JAM3-1074HCL Recombinant Human JAM3 cell lysate Human Cell N/A
Human JAM3-793H Recombinant Human JAM3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human JAM3-2689H Recombinant Human JAM3 protein, hFc&His-tagged HEK293 hFc&His Val32-Asn241 (Ala149Pro)
Human JAM3-6258H Recombinant Human JAM3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human JAM3-1707H Recombinant Human JAM3 Protein, His&GST-tagged E.coli N-His&GST Val32-Val309
Mouse Jam3-5667M Active Recombinant Mouse Junction Adhesion Molecule 3, Fc-tagged Mammalian cells Fc
Mouse Jam3-790M Recombinant Mouse Jam3 protein(Met1-Asn241), His-tagged HEK293 C-His Met1-Asn241
Mouse JAM3-2283MCL Recombinant Mouse JAM3 cell lysate Human Cell N/A
Mouse Jam3-1871M Recombinant Mouse Jam3 protein, His & T7-tagged E.coli His/T7 Glu30~Asn241 (Accession # Q9D8B7)
Mouse Jam3-3630M Recombinant Mouse Jam3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Jam3-80M Recombinant Mouse Jam3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Jam3-80M-B Recombinant Mouse Jam3 Protein Pre-coupled Magnetic Beads HEK293
Rat JAM3-3138R Recombinant Rat JAM3 Protein Mammalian Cell His
Rat JAM3-2794R Recombinant Rat JAM3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat JAM3-2794R-B Recombinant Rat JAM3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Jam3 involved in several pathways and played different roles in them. We selected most pathways Jam3 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with Jam3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell adhesion molecules (CAMs)CLDN15LA;HLA-B;CD4;NCAM1;PDCD1;CLDN7A;CLDNH;H2-AB1;MHC2DCB
Tight junctionMYH1C;MYH13;SHROOM4;ACTG1;MYH1;MYH7B;CLDN18;CLDN10A;MYL5
Leukocyte transendothelial migrationMYL10;MSN;MYL12A;ITGB2L;GNAI3;ESAM;ITGB2;CYBA;CLDN22
Epithelial cell signaling in Helicobacter pylori infectionATP6V1H;IL-8;MAPK13;NFKBIA;ATP6V1B1;RELA;PTPN11;NOD1;MAPK8

Jam3 has several biochemical functions, for example, integrin binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Jam3 itself. We selected most functions Jam3 had, and list some proteins which have the same functions with Jam3. You can find most of the proteins on our site.

Function Related Protein
integrin bindingADAMTS5;ADAMTS8;ILK;SYK;VTN;CD9;PXN;ICAM5;FN1
protein bindingPTPN3;ALS2CR11;CCT4;CHAMP1;BCKDK;SOST;GLYAT;SECISBP2;UBE2N
protein heterodimerization activityNR2C2;Bcl2a1b;NKX2-5;GRIN2A;MCL1;H2AFB3;PRMT8;TBX18;IKBKG
protein homodimerization activityTFAP2B;LGALS6;ENPP1;BMPR1A;CARD9;GDF6;TRIM5;SLK;IL12B

Jam3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Jam3 here. Most of them are supplied by our site. Hope this information will be useful for your research of Jam3.

JAM2; PARD3

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