KALRN

  • Official Full Name

    kalirin, RhoGEF kinase

  • Overview

    Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    KALRN;kalirin, RhoGEF kinase;HAPIP, huntingtin associated protein interacting protein (duo);kalirin;ARHGEF24;DUET;duo;Hs.8004;serine/threonine kinase with Dbl and pleckstrin homology domains;TRAD;huntingtin-associated protein interacti
Cat.# Product name Source (Host) Species Tag Protein Length Price
KALRN-3150R Recombinant Rat KALRN Protein Mammalian Cells Rat His
KALRN-8442M Recombinant Mouse KALRN Protein Mammalian Cells Mouse His
KALRN-2806R Recombinant Rat KALRN Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
KALRN-2806R-B Recombinant Rat KALRN Protein Pre-coupled Magnetic Beads HEK293 Rat
KALRN-4696M Recombinant Mouse KALRN Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KALRN-4696M-B Recombinant Mouse KALRN Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KALRN involved in several pathways and played different roles in them. We selected most pathways KALRN participated on our site, such as Axon guidance,Cell death signalling via NRAGE, NRIF and NADE,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KALRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology WDR83,DUSP1,CLTB,EPHB4A,KIF4A,CDK5R1B,RHOGA,NTN1A,FRS3,ST8SIA2
    Axon guidance AP2B1,UNC5C,SEMA3AA,SEMA3B,ABLIM1,CSNK2A1,LIMK1,EPHA4,PAK4,CDC42
    G alpha (q) signalling events TAC3,GCGA,APPA,GPR17,GCGB,AGTR1,NMBB,GPR65,NMUR1,DGKQ
    Cell death signalling via NRAGE, NRIF and NADE ITGB3BP,ITSN1,ABR,ECT2,OBSCN,ARHGEF3,AATF,MCF2L,ARHGEF18A,FGD4A
    EPHB-mediated forward signaling ACTR3,ACTR2,EFNB2,EPHB4A,EFNB2A,EFNB3,ARPC1B,ARPC2,ARHGEF28,ARPC4
    EPH-Ephrin signaling EPHB4A,EFNB2,AP2A2,EPHB3A,EFNA2A,ARPC4,EFNA3B,DNM1,EFNB2A,EPHA2A
    G alpha (12/13) signalling events ADRA1D,OBSCN,PLEKHG2,ARHGAP4A,ARHGEF3,ADRA1B,FGD2,MCF2L,ARHGEF18,RHOC
    GPCR downstream signaling RGS18,RGS17,SSTR4,ADRA2C,CXCR6,RGS1,SOUL4,GPR4,CCR7,ARHGEF1A

    Protein Function

    KALRN has several biochemical functions, for example, ATP binding,Rho guanyl-nucleotide exchange factor activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KALRN itself. We selected most functions KALRN had, and list some proteins which have the same functions with KALRN. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding HMOX1,LYAR,ZNF263,NR6A1B,ZNF786,C1GALT1A,PHF2,ATP2B3B,MOB2,ZBTB8A
    protein serine/threonine kinase activity MAPK12B,TAOK3,TTK,MAP3K13,CSNK1D,CDK5,ADCK2,BMP2K,MAPK8A,DCKL1B
    nucleotide binding RAB5AA,ARL4CA,ULK1A,ITPK1A,HNRNPH1,ABCA5,DAZAP1,EPHB4A,PRKACAA,ARL3L1
    enzyme binding POR,TSPAN15,PIAS3,YWHAH,UBE2L3,CCDC99,DNM2,TTN,LAMP1,NCOA1
    Rho guanyl-nucleotide exchange factor activity NET1,TRIOA,FGD5,ARHGEF11,FGD4A,ARHGEF39,DOCK10,DNMBP,PLEKHG6,FARP1
    transferase activity NIM1,ZDHHC18A,SAT2A,PIGB,MARCKSA,GRK1A,UBIAD1,TNK2B,STT3B,LTK
    kinase activity RIPK4,PKN1B,BAIAP2L1A,IGF1RB,PRKG1A,IGF1RA,PRKAR2AB,MTOR,MAPK12B,CKBA
    protein kinase activity PRKCHA,IGF1RB,CDK5,INSRB,CDC7,NLK2,PAK4,PDK1,EGFRA,MOK
    guanyl-nucleotide exchange factor activity ARHGEF7,RASGEF1BA,KNDC1,EIF2B5,ITSN2A,DOCK6,ITSN1,RANGRF,FAM116B,SERGEF

    Interacting Protein

    KALRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KALRN here. Most of them are supplied by our site. Hope this information will be useful for your research of KALRN.

    HAP1;Sncaip;Grin1;Grin2b;Dlg4;Ywhab

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