KALRN

  • Official Full Name

    kalirin, RhoGEF kinase

  • Overview

    Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    KALRN;kalirin, RhoGEF kinase;HAPIP, huntingtin associated protein interacting protein (duo);kalirin;ARHGEF24;DUET;duo;Hs.8004;serine/threonine kinase with Dbl and pleckstrin homology domains;TRAD;huntingtin-associated protein interacti
Cat.# Product name Source (Host) Species Tag Protein Length Price
KALRN-3150R Recombinant Rat KALRN Protein Mammalian Cells Rat His
KALRN-8442M Recombinant Mouse KALRN Protein Mammalian Cells Mouse His
KALRN-2806R Recombinant Rat KALRN Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
KALRN-2806R-B Recombinant Rat KALRN Protein Pre-coupled Magnetic Beads HEK293 Rat
KALRN-4696M Recombinant Mouse KALRN Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KALRN-4696M-B Recombinant Mouse KALRN Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KALRN involved in several pathways and played different roles in them. We selected most pathways KALRN participated on our site, such as Axon guidance,Cell death signalling via NRAGE, NRIF and NADE,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KALRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance NRP2,SEMA3AB,NTN1A,DLG3,DPYSL5A,UNC5C,PTK2,SRGAP1,MYL9,Unc5b
    EPH-Ephrin signaling AP2B1,EPHA2,EFNB3,EFNA4,CLTB,ARPC2,ACTR2B,EPHB3A,DNM1,ARHGEF28
    G alpha (12/13) signalling events ARHGEF3,ARHGEF16,ARHGEF9,ARHGEF17,FGD4A,RHOC,RHOGA,RHOAE,ARHGAP4A,TIAM2
    GPCR downstream signaling ARHGEF16,ARHGEF25,SST1.1,OPN4,DGKB,CXCL11.8,QRFPR,AMCF-II,RGS17,TAAR1
    G alpha (q) signalling events TRH,TAC1,OPN4.1,MLN,EDN1,UTS2,LPAR5A,RGS19,APPA,TRPC3
    Developmental Biology AP2A1,NR2F2,CACNG2,DRAP1,CEBPB,LGI1,KIF4A,DPYSL3,FGF18B,SPRED3
    Cell death signalling via NRAGE, NRIF and NADE FGD4A,DCLRE1B,PLEKHG2,AKAP13,ARHGEF17,ARHGEF9,ARHGAP4,BCL2L11,TIAM2,ARHGEF18A
    EPHB-mediated forward signaling ACTR3,KALRNB,ARPC5,ACTR2,ARHGEF28,EPHB3A,CFL1,ARPC4,EPHB4A,ARPC2

    Protein Function

    KALRN has several biochemical functions, for example, ATP binding,Rho guanyl-nucleotide exchange factor activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KALRN itself. We selected most functions KALRN had, and list some proteins which have the same functions with KALRN. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity PLEKHG3,ARHGEF11,ARHGEF37,VAV3B,ARHGEF18,ARHGEF39,FGD1,ARHGEF19,KALRNB,C3A.1
    nucleotide binding CNGA4,HNRNPH2,MVDA,TRNAU1APB,FGFR1A,TRIO,MYHC4,KITB,AKT2L,ACLYA
    metal ion binding WDFY2,LEPREL1,MMP30,ZNF395B,ZDHHC15A,MAT2AB,ZNHIT2,CSK,TRP63,BCL11BA
    guanyl-nucleotide exchange factor activity FGD2,TRIOA,TRIO,RIC8A,RIC8B,RASGRF2B,RAPGEF3,FGD4,FLCN,DOCK5
    transferase activity TLK1B,SULT6B1,MAP2K4A,CMASA,AGPHD1,BMPR1AA,CSNK1G2B,LRGUK,MLL1,MOB1BA
    protein kinase activity SCYL2,BMPR2A,TSSK1,CSNK1D,CAMK1GB,EPHA2A,NPR1A,PDK1,JAK2,CDK5R1
    ATP binding PYGL,GLYCTK,Atp8a2,GCLC,PANK1,SKIV2L,BMPR1BA,MAPK10,IKBKAP,PCXB
    protein serine/threonine kinase activity ROCK2,MAP2K6,AURKA,CDC42BPB,CSNK1A1,BUB1B,PHKG2,NEK1,CDK12,MKNK2
    kinase activity NLK2,PTK6B,PIP5K1BA,PI4KAP2,MARCKSB,PRKCBB,AKT2L,DCKL1B,ACVR2AA,ERBB3A

    Interacting Protein

    KALRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KALRN here. Most of them are supplied by our site. Hope this information will be useful for your research of KALRN.

    HAP1;Sncaip;Grin1;Grin2b;Dlg4;Ywhab

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