KALRN

  • Official Full Name

    kalirin, RhoGEF kinase

  • Overview

    Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described.

  • Synonyms

    KALRN;kalirin, RhoGEF kinase;HAPIP, huntingtin associated protein interacting protein (duo);kalirin;ARHGEF24;DUET;duo;Hs.8004;serine/threonine kinase with Dbl and pleckstrin homology domains;TRAD;huntingtin-associated protein interacti
Cat.# Product name Source (Host) Species Tag Protein Length Price
KALRN-3150R Recombinant Rat KALRN Protein Mammalian Cells Rat His
KALRN-8442M Recombinant Mouse KALRN Protein Mammalian Cells Mouse His
KALRN-2806R Recombinant Rat KALRN Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
KALRN-2806R-B Recombinant Rat KALRN Protein Pre-coupled Magnetic Beads HEK293 Rat
KALRN-4696M Recombinant Mouse KALRN Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
KALRN-4696M-B Recombinant Mouse KALRN Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    KALRN involved in several pathways and played different roles in them. We selected most pathways KALRN participated on our site, such as Axon guidance,Cell death signalling via NRAGE, NRIF and NADE,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KALRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    G alpha (q) signalling events CHRM3,TAC3,DGKG,OPN4B,AGTR1,TAE1,KALRNB,RGS18,OPN4,AGT
    EPHB-mediated forward signaling EFNB3B,EFNB3,ARHGEF28,EPHB4B,EFNB2A,ITSN1,EPHB4A,ARPC1B,ARPC1A,ARPC3
    Developmental Biology GFRA1,FRS2A,EFNA1A,FOXH1,DUSP10,CTNNA2,WDR83,GFRA2,FGF18B,SPTBN2
    GPCR downstream signaling ADRA2A,OR56A1,OPN1LW2,TAE1,RHOB,GPR17,ARHGEF18,HRH3,TAS2R7,ARHGAP4
    G alpha (12/13) signalling events ARHGEF1A,ADRA1D,ARHGEF16,RHOGA,PLEKHG2,TRIO,FGD4A,GNA13,ECT2,ARHGEF1B
    Axon guidance HBEGF,GPC1A,DUSP2,DCC,PLXND1,SLIT1,FYN,MYL12A,CDC42,FGF8B
    Cell death signalling via NRAGE, NRIF and NADE AKAP13,PLEKHG2,DCLRE1B,FGD4A,ITSN1,ARHGEF18A,BCL2L11,FGD4,ECT2,OBSCN
    EPH-Ephrin signaling ARPC5,EPHA2,ACTR2,CFL1,ARPC1B,EPHB4A,EFNB2,ITSN1,AP2M1,ARPC4

    Protein Function

    KALRN has several biochemical functions, for example, ATP binding,Rho guanyl-nucleotide exchange factor activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KALRN itself. We selected most functions KALRN had, and list some proteins which have the same functions with KALRN. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity ABR,ARHGEF39,ITSN2A,FLJ20184,ARHGEF9,VAV2,ARHGEF11,FARP2,ITSN1,DCLRE1B
    kinase activity CAMK2A,NMRK2,DCLK2,SRC,DYRK1AA,JAK2A,UCK2A,ADKB,TAB3,CDK14
    protein serine/threonine kinase activity VRK2,BCR,MAPK8A,ACVRL1,PRKCBA,MAPK8,CSNK2A2,CSNK1D,ICK,STK17B
    enzyme binding UBE4B,CYP3A4,GNB2L1,PIAS3,HIST1H2AK,A2M,MAPT,TMBIM6,PHB,CBX1
    transferase activity NME2A,NADKD1,A3GALT2,ETNPPL,TSSK5,CAMK1DB,EPHA2A,UGT5A2,COQ2,CKBB
    metal ion binding ZNF221,ZEB2A,ZNF274,ZC4H2,VDRA,GALNT5,Gh,NRD1B,KSR2,ACVR1C
    nucleotide binding GATB,MOV10B.1,DDX3,PRKACBA,CPEB2,NLK1,NOL8,RBM4.3,KIF3CB,EWSR1
    guanyl-nucleotide exchange factor activity RASGEF1C,DOCK5,P2RY12,GCGR,GAPVD1,VAV1,FARP2,FGD5,RIC8,DIS3
    protein kinase activity Fert2,HIPK3A,PDGFRA,MAP2K4B,CSNK1A1,ADRBK1,CSNK1G2B,BMPR1AB,MAPK8A,PDK4

    Interacting Protein

    KALRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KALRN here. Most of them are supplied by our site. Hope this information will be useful for your research of KALRN.

    HAP1;Sncaip;Grin1;Grin2b;Dlg4;Ywhab

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