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KAT8

Official Full Name

K(lysine) acetyltransferase 8
Overview

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Synonyms

KAT8; K(lysine) acetyltransferase 8; MOF; hMOF; MYST1; ZC2HC8; histone acetyltransferase KAT8; MYST-1; lysine acetyltransferase 8; histone acetyltransferase MYST1; MYST histone acetyltransferase 1; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1; probable histone acetyltransferase MYST1; ortholog of Drosophila males absent on the first (MOF);

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Sf9 Insect Cell

Tag

GST
His
His (Fc)
Avi
N/A
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KAT8-6957H	Recombinant Human KAT8 , GST-tagged	Sf9 Insect Cell	GST	2-467 aa	Inquiry
Human	KAT8-1602H	Recombinant Human K(Lysine) Acetyltransferase 8, GST-tagged	Sf9 Insect Cell	GST		Inquiry
Human	KAT8-1162HCL	Recombinant Human KAT8 cell lysate		N/A		Inquiry
Human	KAT8-0524H	Recombinant Human KAT8 Protein (M1-K458), Tag Free	E.coli	No tag	M1-K458	Inquiry
Mouse	KAT8-8453M	Recombinant Mouse KAT8 Protein	Mammalian Cell	His		Inquiry
Mouse	KAT8-4703M	Recombinant Mouse KAT8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	KAT8-4703M-B	Recombinant Mouse KAT8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	KAT8-3158R	Recombinant Rat KAT8 Protein	Mammalian Cell	His		Inquiry
Rat	KAT8-2814R	Recombinant Rat KAT8 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	KAT8-2814R-B	Recombinant Rat KAT8 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	KAT8-12013Z	Recombinant Zebrafish KAT8	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

KAT8 involved in several pathways and played different roles in them. We selected most pathways KAT8 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Chromatin modifying enzymes	KDM1A;CHD4A;JADE1;CHD4;PADI4;SAP130;KDM4B;KAT7A;ATF7IP
Chromatin organization	CARM1;KDM3B;COPRS;PADI4;ING5;SMARCC2;HMG20B;ENY2;PHF2
HATs acetylate histones	MORF4L1;ZZZ3;KAT7B;KAT6A;KAT8;C20orf20;ELP2;USP22;YEATS4
p53 pathway	FBXO11;TTC5;HUWE1;NEDD8;TRIM28;RASSF1;PPP1R13L;E4F1;CSE1L

KAT8 has several biochemical functions, for example, acetyltransferase activity, enzyme binding, histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT8 itself. We selected most functions KAT8 had, and list some proteins which have the same functions with KAT8. You can find most of the proteins on our site.

Function	Related Protein
acetyltransferase activity	Acnat1;Nat3;KAT8;KAT6B;CML5;HHAT;KAT2B;MBOAT4;EP300
enzyme binding	NPM2;Ar;HAND1;DNM2;MARCH6;PAWR;LUC7L2;RXRA;ITGB3
histone acetyltransferase activity	KAT7A;KAT6B;CREBBP;KAT8;TAF1;GTF3C4;MED24;KAT7B;KAT2B
contributes_to histone acetyltransferase activity (H4-K16 specific)	PHF20B;KAT8;KIAA1267;MCRS1;HCFC1;KANSL2;KANSL3;OGT
contributes_to histone acetyltransferase activity (H4-K5 specific)	KANSL2;KIAA1267;MCRS1;OGT;KAT8;KANSL3;HCFC1;PHF20B
contributes_to histone acetyltransferase activity (H4-K8 specific)	MCRS1;KANSL2;PHF20B;HCFC1;KAT8;KIAA1267;KANSL3;OGT
metal ion binding	CA14;AFP;FOLH1;RCVRNA;ZNF562;ZNF167;TRIM35-7;AURKB;APLF
methylated histone binding	TP53BP1;DPPA3;RRP8;FAM156A;ATRX;PHF19;JHDM1D;MTF2;SPIN1
protein binding	MAPKAPK2;ALKBH6;MAU2;BAG3;A1CF;COLGALT2;C2orf65;SSBP3;ARHGAP33
transcription factor binding	HOXA7;FOXC1;SOST;CXXC5;CHCHD2;APBB2;MDFI;NAAA;IFI203

KAT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT8.

KMT2A; TP53; RNF2; WDR5; RBBP5; HHF1; HST2; Kat8; ESRRA; H2AFX; ASH2L