KAT8
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Official Full Name
K(lysine) acetyltransferase 8 -
Overview
This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Recombinant Proteins
- Zebrafish
- Rat
- Human
- Mouse
- Mammalian Cells
- Sf9 Cells
- E.coli
- HEK293
- His
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| KAT8-12013Z | Recombinant Zebrafish KAT8 | Mammalian Cells | Zebrafish | His |
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| KAT8-3158R | Recombinant Rat KAT8 Protein | Mammalian Cells | Rat | His |
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| KAT8-6957H | Recombinant Human KAT8 , GST-tagged | Sf9 Cells | Human | GST | 2-467 aa |
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| KAT8-8453M | Recombinant Mouse KAT8 Protein | Mammalian Cells | Mouse | His |
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| KAT8-1162HCL | Recombinant Human KAT8 cell lysate | Human | Non |
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| KAT8-0524H | Recombinant Human KAT8 Protein (M1-K458), Tag Free | E.coli | Human | Non | M1-K458 |
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| KAT8-2814R | Recombinant Rat KAT8 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| KAT8-2814R-B | Recombinant Rat KAT8 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| KAT8-4703M | Recombinant Mouse KAT8 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| KAT8-4703M-B | Recombinant Mouse KAT8 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
KAT8 involved in several pathways and played different roles in them. We selected most pathways KAT8 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with KAT8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | C17orf81,BRD8,PADI1,MBD3A,SMARCC1B,MSL2B,ARID4A,MBD3B,CAPNS2,ACTL6B |
| HATs acetylate histones | MORF4L2,ANO9A,BRPF3,KANSL2,ELP4,BRD8,MSL2A,EP400,ATXN7,ING3 |
| Chromatin modifying enzymes | JMJD6,PHF20B,SUDS3,COPRS,KAT7B,HMG20B,KDM3B,KANSL3,RUVBL2,MORF4L1 |
| p53 pathway | E4F1,DYRK2,NEDD8,SMYD2,RASSF1,HUWE1,TRIM28,FBXO11,TTC5,CSE1L |
Protein Function
KAT8 has several biochemical functions, for example, acetyltransferase activity,enzyme binding,histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KAT8 itself. We selected most functions KAT8 had, and list some proteins which have the same functions with KAT8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | FOXO4,PDCD11,MAPK9,E2F5,PPP1R13L,CDK9,SMAD2,PBX2,MDFIC,TLE1 |
| contributes_to histone acetyltransferase activity (H4-K16 specific) | KIAA1267,HCFC1,OGT,KANSL2,PHF20B,KANSL3,MCRS1 |
| acetyltransferase activity | HHAT,Acnat1,MBOAT4,CML5,DGAT2L6,MBOAT7,KAT2B,AANAT1,ACNAT2,MBOAT1 |
| enzyme binding | NR5A1,PGR,LGALS9,RPS3,RCOR2,NPM2,PTPLA,LDB2,NPC2,HMGA1 |
| histone acetyltransferase activity | MED24,KAT7A,CSRP2BP,ATF2,EP300,GTF3C4,NCOA1,CDYL,CLOCK,KAT7B |
| protein binding | AP1S2,ATXN7,TXNIP,PCDH18B,RERE,GABPB1,BLVRA,ACACA,VEGFB,PIK3CD |
| contributes_to histone acetyltransferase activity (H4-K5 specific) | HCFC1,KANSL3,KIAA1267,KANSL2,PHF20B,MCRS1,OGT |
| metal ion binding | CD209,PDE8A,RPS27L,ZFP879,SP1,ALPPL2,PRDM14,MCM2,NUBP2,ZNF292A |
| methylated histone binding | CHD1,CBX5,L3MBTL1,MPHOSPH8,TDRD3,CBX7,PHF19,PHF1,LOXL2,CBX8 |
Interacting Protein
KAT8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KAT8 here. Most of them are supplied by our site. Hope this information will be useful for your research of KAT8.
KMT2A;TP53;RNF2;WDR5;RBBP5;HHF1;HST2;Kat8;ESRRA;H2AFX;ASH2L
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