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Official Full Name potassium voltage-gated channel, shaker-related subfamily, beta member 1
Background Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.
Synonyms KCNAB1; potassium voltage-gated channel, shaker-related subfamily, beta member 1; voltage-gated potassium channel subunit beta-1; AKR6A3; hKvb3; hKvBeta3; KCNA1B; Kvb1.3; K(+) channel subunit beta-1; potassium channel beta 3 chain; potassium channel beta3
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KCNAB1-1268H Recombinant Human KCNAB1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human KCNAB1-231H Recombinant Human KCNAB1, His-tagged E.coli His
    Human KCNAB1-232H Recombinant Human KCNAB1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human KCNAB1-5075HCL Recombinant Human KCNAB1 293 Cell Lysate HEK293 N/A
    Mouse Kcnab1-1256M Recombinant Mouse Kcnab1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse KCNAB1-8478M Recombinant Mouse KCNAB1 Protein Mammalian Cell His
    Rat KCNAB1-3169R Recombinant Rat KCNAB1 Protein Mammalian Cell His
    Rhesus Macaque KCNAB1-2346R Recombinant Rhesus monkey KCNAB1 Protein, His-tagged Mammalian Cell His
    Chicken KCNAB1-6468C Recombinant Chicken KCNAB1 Mammalian Cell His

    KCNAB1 involved in several pathways and played different roles in them. We selected most pathways KCNAB1 participated on our site, such as Neuronal System, Potassium Channels, Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNAB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Potassium Channels KCND3; KCNH6; KCNN3; KCNJ1A.6; KCNA5; KCNAB2; KCNA6; KCNA1; KCNMB1; KCNMB2
    Voltage gated Potassium channels KCNA6; KCNAB2B; KCNH5A; KCNB2; KCNAB1A; KCNH6; KCNF1A; KCNG4A; KCNS3; KCNA2
    metapathway biotransformation GAL3ST4; GAL3ST3; SULT1C4; CYP20A1; NAA40; NAT9; CYP4Z1; KCNAB1; CYP4V2; CHST4

    KCNAB1 has several biochemical functions, for example, NADPH binding, aldo-keto reductase (NADP) activity, ion channel binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNAB1 itself. We selected most functions KCNAB1 had, and list some proteins which have the same functions with KCNAB1. You can find most of the proteins on our site.

    Function Related Protein
    aldo-keto reductase (NADP) activity CYB5A; HSD11B1LA; AKR1C4; MIOX; HSD3B5; SDR42E1; AKR1C21; AKR1C6; AKR1B1; HSD3B6
    ion channel binding FGF12; LYN; SLC8A1; ACTN1; TRAPPC2; GPD1L; DLG1; SRI; ACTN3; KCNE2
    potassium channel regulator activity KCNMB1; KCNE3; KCNAB1; DPP10; KCNMB4; DPP6; KCNAB3; SGK2; DRD2; CHP
    voltage-gated potassium channel activity KCNS3A; KCNA1; KCNA2B; KCNC3A; KCNAB3; KCNA6; KCNAB1A; KCNH1A; KCNC1B; HTR3A

    KCNAB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNAB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNAB1.

    SRPK1; ssdna_dtdg; ARRB2

    Lu, AG; Tang, Y; et al. Brain genomics of intracerebral hemorrhage. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 26:230-252(2006).
    Nakahira, K; Shi, GY; et al. Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. JOURNAL OF BIOLOGICAL CHEMISTRY 271:7084-7089(1996).

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