KCNC2

  • Official Full Name

    potassium voltage-gated channel, Shaw-related subfamily, member 2

  • Overview

    The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Three transcript variants encoding three different isoforms have been found for this gene.

  • Synonyms

    KCNC2;potassium voltage-gated channel, Shaw-related subfamily, member 2;potassium voltage-gated channel subfamily C member 2;Kv3.2;voltage-gated potassium channel Kv3.2;MGC138196

Recombinant Proteins

  • Rat
  • Zebrafish
  • Human
  • Mus musculus
  • Mammalian Cells
  • HEK293
  • E.coli
  • His
  • Avi
  • Fc

    Involved Pathway

    KCNC2 involved in several pathways and played different roles in them. We selected most pathways KCNC2 participated on our site, such as Integration of energy metabolism,Metabolism,Neuronal System, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of insulin secretion MARCKSB,ARL2BP,KCNB1,KCNS3,SYT5,MARCKSA,ARL2,KCNS3A
    Metabolism SLC25A21,CYP2R1,CETP,COX6B1,CKMT2A,OAZ1A,PPM1K,CYP2C18,SLC5A6A,CDIPT
    Potassium Channels KCNQ1,KCNJ14,HCN4,KCNC1A,KCNN1,KCNQ2,KCNA6A,KCNMB1,KCNK10B,KCNN1B
    Neuronal System KCNAB1,SYN3,KCNN1B,KCNQ1,SLC1A7B,KCND2,KCNA2B,KCNH8,DLG3,ARL6IP5B
    Integration of energy metabolism RAPGEF4,MARCKSA,GNG13A,ARL2,GNG13B,KCNS3,KCNS3A,KCNB1,KCNJ11,ARL2BP
    Voltage gated Potassium channels KCNG3,KCNB2,KCNC4,KCNS2,KCNA7,KCNH5,KCNS3,KCNS3A,KCNH2,KCNA10

    Protein Function

    KCNC2 has several biochemical functions, for example, delayed rectifier potassium channel activity,ion channel activity,potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNC2 itself. We selected most functions KCNC2 had, and list some proteins which have the same functions with KCNC2. You can find most of the proteins on our site.

    Function Related Protein
    voltage-gated potassium channel activity CNGA5,KCNQ3,KCNH5A,KCNH6A,KCNQ1,KCNA2B,KCNQ5,KCNH1B,KCNAB3,HCN2
    ion channel activity SCN11A,TRPA1B,CACNA1SA,GRIA3A,CHRNA10A,FXYD2,P2RX4A,GRIA3B,KCNA6A,CLCNKB
    potassium channel activity KCNK7,KCNK18,KCNC1A,KCNIP1,KCNB2,KCNF1,KCNK13B,TRPM5,KCNS3A,KCNQ2
    voltage-gated ion channel activity KCNC3B,KCNJ16,KCNS3A,SCN12AA,SCN8AB,CLIC5B,KCNJ1A.6,CX35B,KCNJ11L,GPR89
    delayed rectifier potassium channel activity KCNE1,KCNV2,KCNF1A,KCNA10,KCNA7,KCNB2,KCNS3,KCNC1,KCNG3,KCNQ4

    Interacting Protein

    KCNC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNC2.

    Resources

    References

    • VEH, RW; LICHTINGHAGEN, R; et al. IMMUNOHISTOCHEMICAL LOCALIZATION OF 5 MEMBERS OF THE KV1 CHANNEL SUBUNITS - CONTRASTING SUBCELLULAR LOCATIONS AND NEURON-SPECIFIC CO-LOCALIZATIONS IN RAT-BRAIN. EUROPEAN JOURNAL OF NEUROSCIENCE 7:2189-2205(1995).

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