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KCNH1

Official Full Name

potassium voltage-gated channel, subfamily H (eag-related), member 1
Overview

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.
Synonyms

KCNH1; potassium voltage-gated channel, subfamily H (eag-related), member 1; potassium voltage-gated channel subfamily H member 1; eag; eag1; h eag; Kv10.1; Voltage gated potassium channel subunit Kv10.1; MGC124420; MGC142269; EAG channel 1; Ether a go go potassium channel 1; Ether-a-go-go potassium channel 1; h-eag; hEAG1; KCNH1_HUMAN; M eag; MGC124419; Potassium voltage gated channel subfamily H (eag related), member 1; Voltage-gated potassium channel subunit Kv10.1; OTTHUMP00000034451; OTTHUMP00000034569; ether-a-go-go, Drosophila, homolog of;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rat
Rhesus Macaque

Source

HEK293
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	KCNH1-29891TH	Recombinant Human KCNH1	Wheat Germ	N/A	99 amino acids	Inquiry
Human	KCNH1-5060HCL	Recombinant Human KCNH1 293 Cell Lysate	HEK293	N/A		Inquiry
Rat	KCNH1-3182R	Recombinant Rat KCNH1 Protein	Mammalian Cell	His		Inquiry
Rat	KCNH1-2838R	Recombinant Rat KCNH1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	KCNH1-2838R-B	Recombinant Rat KCNH1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	KCNH1-2353R	Recombinant Rhesus monkey KCNH1 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	KCNH1-2174R	Recombinant Rhesus Macaque KCNH1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	KCNH1-2174R-B	Recombinant Rhesus Macaque KCNH1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

KCNH1 involved in several pathways and played different roles in them. We selected most pathways KCNH1 participated on our site, such as Neuronal System, Potassium Channels, Voltage gated Potassium channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neuronal System	HCN4;KCNA6;CHRNE;KCNJ1A.3;CACFD1;KCNA6A;KCND3;KCNK1A;KCNAB2
Potassium Channels	KCNJ1A.5;KCNAB2B;KCNF1A;KCNH8;KCNG3;KCNK18;KCNAB1A;KCNMB1;KCNJ1A.1
Voltage gated Potassium channels	KCND2;KCNQ3;KCNG3;KCNH6A;KCNA6;KCNAB2;KCNA5;KCNAB1A;KCNS3A

KCNH1 has several biochemical functions, for example, 14-3-3 protein binding, calmodulin binding, NOT cyclic nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNH1 itself. We selected most functions KCNH1 had, and list some proteins which have the same functions with KCNH1. You can find most of the proteins on our site.

Function	Related Protein
14-3-3 protein binding	PRKCE;HDAC7;SRPK2;PPP1R12A;ZFP36;AKT1;IRS2;KCNH1;TSC2
calmodulin binding	MYO5C;KCNN1A;MAPKAPK2B;OBSCN;MYO1G;RRAD;CASK;RIT1;PHKA2
NOT cyclic nucleotide binding
delayed rectifier potassium channel activity	KCNG2;KCNG4A;KCNB2;KCNA10;KCNF1;KCNA5;KCNA7;KCNV2;KCNC4
ion channel binding	KCND3;KCNH1;SLC14A2;PRKCSH;KCNE4;SNTA1;YES1;AKAP9;KCNE2
phosphorelay sensor kinase activity	KCNH1A;KCNH8;CASS4;KCNH2;KCNH1B;KCNH5;KCNH5A;KCNH1
protein binding	RD3;PMP2;NOG;FMR1;DAAM1;PATL1;LRRC3;CLPB;SPRR1A
protein heterodimerization activity	YWHAH;SFRP5;LIMK2;HIST2H4A;SPNA1;CXorf15;RAF1;BTBD11;VEGFA
protein kinase binding	ADRA2A;TPCN2;KCNH1;MS4A2;STXBP1;BCL10;TRAF2;TRAF3;TEX14

KCNH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNH1.

CALM1; SDCBP; FASTKD5; WDYHV1; S100B; Rabep1; Kcnh1; RAB7A