Kcnn2

  • Official Full Name

    Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
  • Synonyms

    KCNN2;potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2;small conductance calcium-activated potassium channel protein 2;SKCa 2;small conductance calcium-activated potassium channel subfamily N member 2;SK2;fri;SKCA2;KCa2.2

Recombinant Proteins

  • Rat
  • Chicken
  • Mouse
  • Human
  • Mus musculus
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Avi
  • Fc

    Involved Pathway

    Kcnn2 involved in several pathways and played different roles in them. We selected most pathways Kcnn2 participated on our site, such as BDNF signaling pathway,Bile secretion,Ca2+ activated K+ channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with Kcnn2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin secretion FFAR1,ATP1A1,CAMK2B,CAMK2G,STX1A,ITPR3,PRKACG,KCNMB3,KCNMA1,ATP1B2
    Ca2+ activated K+ channels KCNN4,KCNN1B,KCNN3,KCNN1,KCNN1A,KCNMB1,KCNMA1,KCNMB2
    Potassium Channels KCNMA1,KCNA6,KCNH6,KCNK7,KCNA1,KCNK6,KCNA5,KCNK2,KCNQ2,KCNH5
    BDNF signaling pathway EIF2S1,DPYSL2,IGF2BP1,FRS3,EIF4E,DOK5,JAK2,YBX1,EGR2,CSNK2A1P
    Bile secretion ABCB1A,RXRA,SCTR,NR0B2,SLC9A1,SLCO1A2,ABCB4,OSTA,SLC10A2,ADCY9
    Neuronal System KCNC1,KCNG4A,KCNB2,KCNK3A,KCNAB2,GJC1,KCNK13B,KCNV1,KCNA7,KCNA1
    Serotonergic synapse PTGS1,Casp3,GNB1,HTR1E,PLCB4,ALOX12B,PRKACB,HTR3C,HTR7,GNG11

    Protein Function

    Kcnn2 has several biochemical functions, for example, alpha-actinin binding,calcium-activated potassium channel activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Kcnn2 itself. We selected most functions Kcnn2 had, and list some proteins which have the same functions with Kcnn2. You can find most of the proteins on our site.

    Function Related Protein
    calmodulin binding DAPK1,CDK5RAP2,PPP3CB,PATE4,PLA2G6,CAMK2G1,SLC8A1,CAMK1G,CASK,ADD3
    protein homodimerization activity UGT1A7,OXCT1,AMICA1,CADM1A,ADAM10,CAMK2B,CDA,ZBTB16,NKX2,PTS
    small conductance calcium-activated potassium channel activity KCNN1,KCNN1A,KCNN1B,KCNN3
    alpha-actinin binding MAGI1,ALMS1,XIRP2,KCNA5,LRRC10,ADORA2A,DAG1,PPARG,RARA,PKD2L1
    protein domain specific binding ZNF521,SKI,MTOR,ICAL1,YWHAE,TADA3,VPS11,YWHAG1,PLXND1,HIST2H4A
    calcium-activated potassium channel activity KCNN4,KCNMB2,KCNMA1,KCNT1,PKD2L1,KCNMA1A,KCNN1A,KCNMB4,KCNMB3,MTMR6

    Interacting Protein

    Kcnn2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Kcnn2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Kcnn2.

    SRPK2;SRPK1

    Resources

    References

    • Kim, JJ; Park, YM; et al. Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis. JOURNAL OF HUMAN GENETICS 58:521-525(2013).
    • Chang, SH; Chang, SN; et al. Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 With Atrial Fibrillation in a Taiwanese Population. CIRCULATION JOURNAL 76:184-188(2012).
    • Li, C; Wang, F; et al. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. HUMAN GENETICS 129:239-246(2011).
    • Mauler, F; Hinz, V; et al. Selective intermediate-/small-conductance calcium-activated potassium channel (KCNN4) blockers are potent and effective therapeutics in experimental brain oedema and traumatic brain injury caused by acute subdural haematoma. EUROPEAN JOURNAL OF NEUROSCIENCE 20:1761-1768(2004).

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